SCN4A (sodium voltage-gated channel alpha subunit 4) - Rat Genome Database

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Gene: SCN4A (sodium voltage-gated channel alpha subunit 4) Pan paniscus
Analyze
Symbol: SCN4A
Name: sodium voltage-gated channel alpha subunit 4
RGD ID: 11854693
Description: ENCODES a protein that exhibits sodium channel activity (inferred); voltage-gated sodium channel activity (inferred); INVOLVED IN choline transport (ortholog); monoatomic cation transport (ortholog); potassium ion transport (ortholog); ASSOCIATED WITH congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 16 (ortholog); congenital myopathy (ortholog); FOUND IN axon (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 4 subunit alpha; sodium channel, voltage-gated, type IV, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,119,592 - 80,155,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,939,899 - 84,975,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,034,146 - 58,066,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,128,550 - 63,161,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,128,550 - 63,161,043 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,119,592 - 80,155,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,939,899 - 84,975,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,034,146 - 58,066,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,128,550 - 63,161,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,128,550 - 63,161,043 (-)Ensemblpanpan1.1panPan2
SCN4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,938,554 - 63,972,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,938,554 - 63,972,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,015,914 - 62,050,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,369,646 - 59,404,010 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,369,645 - 59,404,010NCBI
Celera1756,403,975 - 56,438,354 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,383,629 - 57,417,946 (-)NCBIHuRef
CHM1_11762,079,833 - 62,114,196 (-)NCBICHM1_1
T2T-CHM13v2.01764,809,317 - 64,843,693 (-)NCBIT2T-CHM13v2.0
Scn4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,208,374 - 106,256,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,209,418 - 106,244,114 (-)EnsemblGRCm39 Ensembl
GRCm3811106,317,545 - 106,365,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,318,592 - 106,353,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,179,907 - 106,210,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,135,394 - 106,165,480 (-)NCBIMGSCv36mm8
Celera11118,049,260 - 118,080,125 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.91NCBI
Scn4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,745,459 - 91,796,452 (-)NCBIGRCr8
mRatBN7.21091,246,936 - 91,296,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,246,936 - 91,296,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,301,564 - 96,351,302 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,764,729 - 95,814,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,175,309 - 91,225,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,505,026 - 94,557,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,505,026 - 94,557,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,256,140 - 94,305,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,710,710 - 95,760,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,725,079 - 95,774,693 (-)NCBI
Celera1089,922,418 - 89,970,101 (-)NCBICelera
RH 3.4 Map10988.7RGD
Cytogenetic Map10q32.1NCBI
Scn4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,861,585 - 7,906,192 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,861,585 - 7,906,192 (+)NCBIChiLan1.0ChiLan1.0
SCN4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,849,066 - 11,893,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,851,347 - 11,877,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0913,510,606 - 13,554,819 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,510,606 - 13,539,011 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,457,351 - 12,500,840 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,030,745 - 15,074,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,032,962 - 15,077,426 (+)NCBIUU_Cfam_GSD_1.0
Scn4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,610,329 - 14,653,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,543,102 - 4,569,862 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,541,061 - 4,570,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,002,175 - 15,047,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,001,356 - 15,048,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,992,881 - 15,039,475 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,273,143 - 57,331,677 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,282,252 - 57,331,035 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607727,910,000 - 27,944,696 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,436,047 - 1,483,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,436,372 - 1,483,531 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000053915   ⟹   ENSPPAP00000031051
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1763,128,550 - 63,161,043 (-)Ensembl
RefSeq Acc Id: XM_055102143   ⟹   XP_054958118
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21980,119,592 - 80,155,917 (-)NCBI
NHGRI_mPanPan11784,939,899 - 84,975,867 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054958118 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031051.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000031051   ⟸   ENSPPAT00000053915
RefSeq Acc Id: XP_054958118   ⟸   XM_055102143
Protein Domains
Ion transport   Sodium ion transport-associated


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053915.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Na_channel_a4su_mammal UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100973259 UniProtKB/TrEMBL
NCBI Gene SCN4A ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
  NACHANNEL4 UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9BN28_PANPA UniProtKB/TrEMBL