XRCC2 (X-ray repair cross complementing 2)

Gene: XRCC2 (X-ray repair cross complementing 2) Pan paniscus

Analyze

Symbol:

XRCC2

Name:

X-ray repair cross complementing 2

RGD ID:

11854431

Description:

ENCODES a protein that exhibits four-way junction DNA binding (ortholog); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH autistic disorder (ortholog); breast carcinoma (ortholog); Breast Neoplasms (ortholog); FOUND IN centrosome (inferred); intracellular membrane-bounded organelle (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA repair protein XRCC2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	189,063,506 - 189,091,518 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	41,073,530 - 41,101,676 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	144,229,031 - 144,256,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	156,378,685 - 156,406,516 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	156,378,685 - 156,406,516 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

breast carcinoma (ISO)

Breast Neoplasms (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

Fanconi anemia complementation group U (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

lethal congenital glycogen storage disease of heart (ISO)

long QT syndrome (ISO)

pancreatic cancer (ISO)

primary ovarian insufficiency 17 (ISO)

SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION (ISO)

spermatogenic failure 50 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

centrosome cycle (IEA)

DNA damage response (IEA,ISO)

DNA metabolic process (IEA)

DNA repair (IEA)

DNA strand invasion (IEA)

double-strand break repair via homologous recombination (IEA,ISO)

in utero embryonic development (IEA,ISO)

mitotic cell cycle (IEA)

multicellular organism growth (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,ISO)

neurogenesis (IEA,ISO)

positive regulation of neurogenesis (IEA,ISO)

regulation of fibroblast apoptotic process (IEA,ISO)

response to gamma radiation (IEA,ISO)

response to X-ray (IEA,ISO)

somitogenesis (IEA,ISO)

Cellular Component

centrosome (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

Rad51B-Rad51C-Rad51D-XRCC2 complex (IEA)

replication fork (IEA)

Molecular Function

ATP binding (IEA)

ATP-dependent DNA damage sensor activity (IEA)

DNA binding (IEA)

four-way junction DNA binding (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

homologous recombination pathway of double-strand break repair (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

XRCC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	189,063,506 - 189,091,518 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	41,073,530 - 41,101,676 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	144,229,031 - 144,256,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	156,378,685 - 156,406,516 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	156,378,685 - 156,406,516 (-)	Ensembl	panpan1.1		panPan2

XRCC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	152,644,776 - 152,676,141 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	152,644,776 - 152,676,193 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	152,341,861 - 152,373,226 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	151,974,516 - 152,004,183 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	151,781,236 - 151,810,898	NCBI
Celera	7	146,907,598 - 146,937,489 (-)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	146,154,439 - 146,184,018 (-)	NCBI		HuRef
CHM1_1	7	152,351,916 - 152,381,649 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	153,818,164 - 153,849,721 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	151,670,667 - 151,700,330 (-)	NCBI

Xrcc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	25,894,812 - 25,910,795 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	25,894,810 - 25,910,823 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	25,689,814 - 25,705,797 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	25,689,812 - 25,705,825 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	25,195,632 - 25,211,615 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	25,199,879 - 25,215,862 (-)	NCBI		MGSCv36	mm8
Celera	5	22,629,689 - 22,645,599 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	12.35	NCBI

Xrcc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	10,157,130 - 10,237,089 (+)	NCBI		GRCr8
mRatBN7.2	4	9,423,873 - 9,502,980 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	9,423,898 - 9,442,482 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	14,422,073 - 14,440,537 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	10,236,354 - 10,254,818 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	8,587,370 - 8,605,854 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	5,842,013 - 5,860,516 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	5,841,998 - 5,860,527 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	5,865,989 - 5,884,492 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	4,817,222 - 4,835,725 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	876,632 - 895,138 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

Xrcc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	6,599,085 - 6,629,439 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	6,579,443 - 6,629,410 (-)	NCBI	ChiLan1.0	ChiLan1.0

XRCC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	16,402,821 - 16,429,095 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	16,402,933 - 16,429,037 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	17,019,573 - 17,045,315 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	18,134,572 - 18,160,367 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	18,134,726 - 18,160,313 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	16,507,780 - 16,533,550 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	17,088,510 - 17,114,628 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	17,139,622 - 17,165,358 (-)	NCBI		UU_Cfam_GSD_1.0

Xrcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	5,118,065 - 5,142,946 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	7,760,719 - 7,785,391 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	7,760,609 - 7,785,360 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XRCC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	4,808,470 - 4,835,802 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	4,808,428 - 4,834,281 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	4,937,262 - 5,312,081 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XRCC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	120,795,188 - 120,827,737 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	120,795,212 - 120,827,706 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	16,791,808 - 16,824,354 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xrcc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	4,355,539 - 4,390,016 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	4,352,566 - 4,389,707 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000042866 ⟹ ENSPPAP00000020080

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	156,378,685 - 156,406,516 (-)	Ensembl

RefSeq Acc Id:

XM_003815782 ⟹ XP_003815830

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	189,063,506 - 189,091,518 (-)	NCBI
NHGRI_mPanPan1	7	41,073,530 - 41,101,676 (-)	NCBI
Mhudiblu_PPA_v0	7	144,229,031 - 144,256,854 (-)	NCBI
PanPan1.1	7	156,378,685 - 156,406,516 (-)	NCBI

Sequence:

show sequence

TGTAGAGTCTGCGCAGTTGGTGAATGGCGTTGGTGGCGGGCAAGTTGAGTCTCTCCTGCGCCGA
GCCTTCGGGGCGATGTGTAGTGCCTTCCATAGGGCTGAGTCTGGGACCGAGCTCCTTGCCCGAC
TTGAAGGTAGAAGTTCCTTGAAAGAAATAGAACCAAATCTGTTTGCTGATGAAGATTCACCTGT
GCATGGTGATATTCTTGAATTTCATGGCCCAGAAGGAACAGGAAAAACAGAAATGCTTTATCAC
CTAACAGCACGATGTATACTTCCCAAATCAGAAGGTGGCCTGGAAGTAGAAGTCTTATTTATTG
ATACAGATTACCACTTTGATATGCTCCGGCTAGTTACAATTCTTGAGCACAGACTATCCCAAAG
CTCTGAAGAAATAATCAAATACTGCCTGGGAAGATTTTTTTTGGTGTACTGCAGTAGTAGCACC
CACTTACTTCTTACACTTTACTCACTAGAAAGTATGTTTTGTAGTCACCCATCTCTCTGCCTTT
TGATTTTGGATAGCCTGTCAGCTTTTTACTGGATAGACCGCGTCAATGGAGGAGAAAGTGTGAA
CTTACAGGAGTCTACTCTGAGGAAATGTTCTCAGTGCTTAGAGAAGCTTGTAAACGACTATCGC
CTGGTTCTTTTTGCAACGACACAAACTATAATGCAGAAAGCCTCGAACTCATCAGAAGAACCTT
CTCATGCCTCTCCACGACTGTGTGATGTGGACATAGACTACAGACCTTATCTCTGTAAGGCATG
GCAGCAACTGGTGAAGCACAGGATGTTTTTCTCCAAACAAGATGATTCTCAAAGCAGCAACCAA
TTTTCATTAGTTTCACGTTGTTTAAAAAGTAACAGTTTAAAAAAACATTTTTTTATTATTGGAG
AAAGTGGGGTTGAATTTTGTTGATATACATCATAAAATAGTCTTTTGCAGGGTACTACGCAAGC
CTTAAAATTTTTCTTAAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCACAATC
ATGGCTCACTGCAGCCTTGAACTCCTGGCCTCAAGGGATCCTCCTATGTGTGCCTCCTAGAGTG
CAGGGATTACAGGCGTGAGCCACGTGCTCGTGGCCAAAAGTTTTCTTCTTTTTTTTCTTTTGAA
ACAGTCTTACTCTGTCTCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCCCGCTGCAGCCTCCG
CCTCCTGGGTTCAAGTGATTCTTCCACCTCAGCCTCCCAGGTAGCTGGGATTACAGGCACCCAC
CACCACGCCTGGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCCAGGCTG
GTCTCGAACTCCGGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGG
CCCGTGCCCAGCCCTAAAGTTTTAAACTCTAGGGGAATTAACAGTATTTCTTTACAGAATGGAT
TTGTTAAACTAGCACAGTAAAAGTAAAGACTATTCTGTTTCTAGGCTGTTGAATCAAAGTGATT
TTAGCAATTAAACTTTGTATTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003815830	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000020080
	ENSPPAP00000020080.1

RefSeq Acc Id:

XP_003815830 ⟸ XM_003815782

- UniProtKB:

A0A2R9AWA0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDILEFHGPEGTGKTEMLYHLTAR
CILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYCSSSTHLLL
TLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQCLEKLVNDYRLVLF
ATTQTIMQKASNSSEEPSHASPRLCDVDIDYRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLV
SRCLKSNSLKKHFFIIGESGVEFC

hide sequence

RefSeq Acc Id:

ENSPPAP00000020080 ⟸ ENSPPAT00000042866

Protein Domains

RecA family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000033251	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000042866.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	DNA_recomb/repair_Rad51_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RecA_ATP-bd	UniProtKB/TrEMBL
	XRCC2	UniProtKB/TrEMBL
KEGG Report	pps:100975649	UniProtKB/TrEMBL
NCBI Gene	XRCC2	ENTREZGENE
PANTHER	DNA REPAIR PROTEIN XRCC2	UniProtKB/TrEMBL
	PTHR46644	UniProtKB/TrEMBL
Pfam	Rad51	UniProtKB/TrEMBL
PROSITE	RECA_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A2R9AWA0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations