BLVRB (biliverdin reductase B) - Rat Genome Database

Name: BLVRB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: BLVRB (biliverdin reductase B) Pan paniscus

Analyze

Symbol:

BLVRB

Name:

biliverdin reductase B

RGD ID:

11853135

Description:

ENCODES a protein that exhibits biliverdin reductase (NAD(P)H) activity (inferred); peptidyl-cysteine S-nitrosylase activity (inferred); riboflavin reductase (NADPH) activity (inferred); INVOLVED IN heme catabolic process (inferred); megakaryocyte differentiation (inferred); negative regulation of insulin receptor signaling pathway (inferred); ASSOCIATED WITH Carpenter Syndrome 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cytoplasm (ortholog); terminal bouton (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

biliverdin reductase B (flavin reductase (NADPH)); flavin reductase (NADPH)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BLVRB (biliverdin reductase B)	NCBI	Ortholog
Mus musculus (house mouse):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	46,710,915 - 46,728,689 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	48,581,558 - 48,601,334 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	37,496,344 - 37,516,127 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	46,007,321 - 46,025,120 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	46,007,321 - 46,025,120 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Carpenter Syndrome 2 (ISO)

Chemical and Drug Induced Liver Injury (ISO)

congenital hypoplastic anemia (ISO)

craniosynostosis (ISO)

Diamond-Blackfan anemia (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

maple syrup urine disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

heme catabolic process (IEA)

megakaryocyte differentiation (IEA)

negative regulation of insulin receptor signaling pathway (IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

terminal bouton (ISO)

Molecular Function

biliverdin reductase (NAD(P)H) activity (IEA)

peptidyl-cysteine S-nitrosylase activity (IEA)

protein binding (ISO)

riboflavin reductase (NADPH) activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

BLVRB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	46,710,915 - 46,728,689 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	48,581,558 - 48,601,334 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	37,496,344 - 37,516,127 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	46,007,321 - 46,025,120 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	46,007,321 - 46,025,120 (-)	Ensembl	panpan1.1		panPan2

BLVRB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	40,447,768 - 40,465,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	40,447,765 - 40,465,764 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	40,953,675 - 40,971,652 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	45,645,541 - 45,663,516 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	45,645,540 - 45,663,517	NCBI
Celera	19	37,753,251 - 37,771,296 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	37,389,108 - 37,406,845 (-)	NCBI		HuRef
CHM1_1	19	40,953,363 - 40,971,359 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	43,268,426 - 43,286,397 (-)	NCBI		T2T-CHM13v2.0

Blvrb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	27,147,403 - 27,165,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	27,147,403 - 27,165,569 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	27,447,978 - 27,465,981 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	27,447,978 - 27,466,144 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	28,232,997 - 28,251,000 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	27,156,738 - 27,174,741 (+)	NCBI		MGSCv36	mm8
Celera	7	22,030,292 - 22,048,354 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	15.9	NCBI

Blvrb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	91,866,258 - 91,883,921 (+)	NCBI		GRCr8
mRatBN7.2	1	82,738,646 - 82,756,312 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	82,738,695 - 82,770,375 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	88,141,751 - 88,159,098 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	96,628,789 - 96,646,213 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	89,897,608 - 89,914,955 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	84,256,063 - 84,273,726 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	84,256,159 - 84,274,075 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	85,468,772 - 85,490,833 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	82,528,943 - 82,546,606	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	77,153,671 - 77,171,142 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Blvrb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955578	813,480 - 838,151 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955578	813,834 - 834,675 (+)	NCBI	ChiLan1.0	ChiLan1.0

BLVRB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	113,244,484 - 113,258,170 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	113,244,503 - 113,258,073 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	112,646,444 - 112,660,113 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	113,842,860 - 113,856,535 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	113,842,878 - 113,856,438 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	113,402,155 - 113,415,836 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,034,647 - 113,048,316 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,028,608 - 114,042,276 (+)	NCBI		UU_Cfam_GSD_1.0

Blvrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	14,380,932 - 14,390,059 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	2,808,950 - 2,818,178 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	2,808,998 - 2,818,123 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BLVRB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	48,715,199 - 48,728,389 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	48,715,540 - 48,728,433 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	44,463,504 - 44,476,949 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BLVRB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	34,902,632 - 34,925,105 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	34,902,598 - 34,925,100 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	13,019,457 - 13,042,205 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Blvrb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624925	432,137 - 452,903 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624925	432,137 - 452,946 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000054572 ⟹ ENSPPAP00000031707

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	46,007,321 - 46,025,120 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000054575 ⟹ ENSPPAP00000031710

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	46,007,422 - 46,024,986 (-)	Ensembl

RefSeq Acc Id:

XM_003812482 ⟹ XP_003812530

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	46,710,915 - 46,728,689 (-)	NCBI
NHGRI_mPanPan1	19	48,581,558 - 48,599,473 (-)	NCBI
Mhudiblu_PPA_v0	19	37,496,344 - 37,514,266 (-)	NCBI
PanPan1.1	19	46,007,321 - 46,025,120 (-)	NCBI

Sequence:

show sequence

GCTGAGGCGTGGCCCTTCGAGCCAGCTCCGCCCCGTTGTTCCTGCTTGAGTAGGGCAGAGAGCA
CCGCCCAGCAGCCAGTGGGTTCCCGCGCGTGCCGAGACTCTGAGGCCTTGCACCCCCACGATCC
CGTAGGATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCC
TGGCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTGCC
ATCAGAGGGGCCCCAGCCGGCCCACGTGGTAGTGGGGGATGTTCTGCAGGCAGCCGATGTGGAC
AAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGACCTCAGTCCCA
CGACAGTGATGTCCGAGGGCGCCCAGAACATTGTGGCAGCCATGAAGGCTCATGGTGTGGACAA
GGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAGGTGCCCCCACGACTGCAG
GCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCAGGAATCAGGCCTGAAGTACGTGG
CTGTGATGCCGCCACACATAGGAGACCAGCCGCTAACTGGGGCGTACACAGTGACCCTGGATGG
ACGAGGGCCCTCAAGGGTCATCTCCAAACATGACCTGGGCCATTTCATGCTGCGCTGCCTCACC
ACCGATGAGTACGACGGACACAGCACCTACCCCTCCCACCAGTACCAGTAGCACTCTGTCCCCA
TCTGGGAGGGTGGCATTCTGGGACATGAGGAGCAAAGGAAGGGGGCAATAAATGTTGAGCCGAG
AGCTTCAAATTACTCTAGAGAAAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003812530	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000031707
	ENSPPAP00000031707.1
	ENSPPAP00000031710.1

RefSeq Acc Id:

XP_003812530 ⟸ XM_003812482

- UniProtKB:

A0A2R9BPX3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPQPAHVVVGDVLQAADVDKT
VAGQDAVIVLLGTRNDLSPTTVMSEGAQNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAV
TDDHIRMHKVLQESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTD
EYDGHSTYPSHQYQ

hide sequence

RefSeq Acc Id:

ENSPPAP00000031707 ⟸ ENSPPAT00000054572

RefSeq Acc Id:

ENSPPAP00000031710 ⟸ ENSPPAT00000054575

Protein Domains

NAD(P)-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038767	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054572.1	UniProtKB/TrEMBL
	ENSPPAT00000054575.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100989093	UniProtKB/TrEMBL
NCBI Gene	BLVRB	ENTREZGENE
PANTHER	FLAVIN REDUCTASE (NADPH)	UniProtKB/TrEMBL
	FLAVIN REDUCTASE (NADPH)	UniProtKB/TrEMBL
Pfam	NAD_binding_10	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A2R9BPX3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BQM3_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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