INPP5B (inositol polyphosphate-5-phosphatase B) - Rat Genome Database

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Gene: INPP5B (inositol polyphosphate-5-phosphatase B) Pan paniscus
Analyze
Symbol: INPP5B
Name: inositol polyphosphate-5-phosphatase B
RGD ID: 11849912
Description: ENCODES a protein that exhibits hydrolase activity (inferred); inositol phosphate phosphatase activity (inferred); inositol-1,4,5-trisphosphate 5-phosphatase activity (inferred); INVOLVED IN flagellated sperm motility (ortholog); in utero embryonic development (ortholog); regulation of protein processing (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Dent Disease 2 (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); early endosome membrane (inferred); endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inositol polyphosphate-5-phosphatase, 75kDa; type II inositol 1,4,5-trisphosphate 5-phosphatase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,020,692 - 188,105,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1138,484,928 - 38,568,449 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl138,485,163 - 38,567,704 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
INPP5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,020,692 - 188,105,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1138,484,928 - 38,568,449 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl138,485,163 - 38,567,704 (-)Ensemblpanpan1.1panPan2
INPP5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38137,860,697 - 37,947,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl137,860,697 - 37,947,053 (-)EnsemblGRCh38hg38GRCh38
GRCh37138,326,369 - 38,412,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36138,098,956 - 38,185,316 (-)NCBINCBI36Build 36hg18NCBI36
Build 34137,995,461 - 38,081,786NCBI
Celera136,604,192 - 36,690,446 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef136,444,364 - 36,530,434 (-)NCBIHuRef
CHM1_1138,442,163 - 38,528,531 (-)NCBICHM1_1
T2T-CHM13v2.0137,727,581 - 37,813,950 (-)NCBIT2T-CHM13v2.0
Inpp5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394124,635,620 - 124,695,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4124,635,643 - 124,695,304 (+)EnsemblGRCm39 Ensembl
GRCm384124,741,827 - 124,801,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4124,741,850 - 124,801,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv374124,419,122 - 124,478,755 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364124,244,182 - 124,303,815 (+)NCBIMGSCv36mm8
Celera4123,062,795 - 123,123,058 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.89NCBI
Inpp5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,281,454 - 142,345,993 (+)NCBIGRCr8
mRatBN7.25136,996,766 - 137,061,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5136,996,686 - 137,061,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5139,701,682 - 139,766,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,471,694 - 141,536,036 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,478,873 - 141,543,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05142,731,767 - 142,796,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5142,731,767 - 142,796,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05146,055,285 - 146,106,355 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05146,503,047 - 146,566,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45144,070,183 - 144,134,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15144,080,175 - 144,144,606 (+)NCBI
Celera5135,519,615 - 135,584,068 (+)NCBICelera
Cytogenetic Map5q36NCBI
Inpp5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545215,629,724 - 15,681,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545215,628,852 - 15,682,514 (-)NCBIChiLan1.0ChiLan1.0
INPP5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,627,536 - 4,678,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,628,278 - 4,678,574 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha154,869,686 - 4,920,085 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,755,524 - 4,806,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,755,547 - 4,867,966 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,616,018 - 4,666,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,682,456 - 4,733,101 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,698,861 - 4,749,418 (+)NCBIUU_Cfam_GSD_1.0
Inpp5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505854,203,793 - 54,259,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647420,028,585 - 20,083,906 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647420,028,575 - 20,083,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl693,885,465 - 93,944,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1693,885,471 - 93,944,398 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2686,656,189 - 86,715,051 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12094,919,605 - 95,001,487 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2094,920,402 - 95,001,248 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603321,810,114 - 21,904,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476420,559,009 - 20,609,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476420,558,145 - 20,610,126 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034961595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034961631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000009357   ⟹   ENSPPAP00000001903
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl138,485,163 - 38,567,704 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000009406   ⟹   ENSPPAP00000001907
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl138,485,219 - 38,567,704 (-)Ensembl
RefSeq Acc Id: XM_034961595   ⟹   XP_034817486
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,692 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBI
RefSeq Acc Id: XM_034961597   ⟹   XP_034817488
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,693 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBI
RefSeq Acc Id: XM_034961608   ⟹   XP_034817499
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,693 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBI
RefSeq Acc Id: XM_034961612   ⟹   XP_034817503
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,530 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,693 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,220,721 (-)NCBI
RefSeq Acc Id: XM_034961617   ⟹   XP_034817508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,904,920 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,034,077 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,207,276 (-)NCBI
RefSeq Acc Id: XM_034961622   ⟹   XP_034817513
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,897,603 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,026,766 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,214,645 (-)NCBI
RefSeq Acc Id: XM_034961625   ⟹   XP_034817516
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,906,258 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,035,404 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,205,993 (-)NCBI
RefSeq Acc Id: XM_034961628   ⟹   XP_034817519
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,582 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,744 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,220,663 (-)NCBI
RefSeq Acc Id: XM_034961631   ⟹   XP_034817522
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,895,097 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,024,190 - 188,105,948 (+)NCBI
Mhudiblu_PPA_v0137,135,442 - 37,215,791 (-)NCBI
RefSeq Acc Id: XM_055095190   ⟹   XP_054951165
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,892,785 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,021,951 - 188,105,948 (+)NCBI
RefSeq Acc Id: XM_055095191   ⟹   XP_054951166
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,892,785 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,021,947 - 188,105,948 (+)NCBI
RefSeq Acc Id: XM_055095192   ⟹   XP_054951167
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,582 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,744 - 188,105,948 (+)NCBI
RefSeq Acc Id: XM_055095193   ⟹   XP_054951168
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,891,582 - 188,976,806 (+)NCBI
NHGRI_mPanPan11188,020,744 - 188,105,948 (+)NCBI
RefSeq Acc Id: XM_063608669   ⟹   XP_063464739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,895,000 - 188,976,806 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034817499   ⟸   XM_034961608
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZE80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817503   ⟸   XM_034961612
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZE80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817488   ⟸   XM_034961597
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZE80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817486   ⟸   XM_034961595
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZE80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817519   ⟸   XM_034961628
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034817522   ⟸   XM_034961631
- Peptide Label: isoform X10
RefSeq Acc Id: XP_034817513   ⟸   XM_034961622
- Peptide Label: isoform X8
RefSeq Acc Id: XP_034817508   ⟸   XM_034961617
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034817516   ⟸   XM_034961625
- Peptide Label: isoform X9
RefSeq Acc Id: ENSPPAP00000001903   ⟸   ENSPPAT00000009357
RefSeq Acc Id: ENSPPAP00000001907   ⟸   ENSPPAT00000009406
RefSeq Acc Id: XP_054951167   ⟸   XM_055095192
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054951168   ⟸   XM_055095193
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054951166   ⟸   XM_055095191
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054951165   ⟸   XM_055095190
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063464739   ⟸   XM_063608669
- Peptide Label: isoform X5
Protein Domains
Inositol polyphosphate-related phosphatase   Rho-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000007165 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000009357.1 UniProtKB/TrEMBL
  ENSPPAT00000009406.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.30.29.110 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  INPP5B_PH_dom UniProtKB/TrEMBL
  IP5 UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
  OCRL-1_2_ASH UniProtKB/TrEMBL
  OCRL1/INPP5B_INPP5c UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  RhoGAP_OCRL1 UniProtKB/TrEMBL
NCBI Gene INPP5B ENTREZGENE
PANTHER INOSITOL 5-PHOSPHATASE UniProtKB/TrEMBL
  TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
  INPP5B_PH UniProtKB/TrEMBL
  OCRL-like_ASH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF56219 UniProtKB/TrEMBL
UniProt A0A2R8ZAM0_PANPA UniProtKB/TrEMBL
  A0A2R8ZE80 ENTREZGENE, UniProtKB/TrEMBL