DNMT1 (DNA methyltransferase 1) - Rat Genome Database

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Gene: DNMT1 (DNA methyltransferase 1) Pan paniscus
Analyze
Symbol: DNMT1
Name: DNA methyltransferase 1
RGD ID: 11847920
Description: ENCODES a protein that exhibits DNA (cytosine-5-)-methyltransferase activity (ortholog); histone deacetylase binding (ortholog); lncRNA binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); cellular response to lead ion (ortholog); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocysteine metabolic pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN nucleus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1-like; LOC103784648
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Fatty Liver  (ISO)
alopecia areata  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autoimmune disease  (ISO)
autosomal dominant cerebellar ataxia, deafness and narcolepsy  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
choline deficiency disease  (ISO)
choreatic disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
dementia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Experimental Arthritis  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 1E  (ISO)
hypertrophic cardiomyopathy  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
medulloblastoma  (ISO)
meningioma  (ISO)
middle cerebral artery infarction  (ISO)
mucoepidermoid carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Oral Lichen Planus  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
Peritoneal Fibrosis  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sleep disorder  (ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to bisphenol A  (IEA,ISO)
cellular response to lead ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromosomal DNA methylation maintenance following DNA replication  (ISO)
DNA methylation-dependent heterochromatin formation  (IEA)
DNA-templated transcription  (IEA,ISO)
epigenetic programming of gene expression  (IEA,ISO)
methylation  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IEA)
neuron differentiation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
regulation of cell population proliferation  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
response to activity  (ISO)
response to alcohol  (ISO)
response to caffeine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DNMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
DNMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,133,342 - 10,231,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,244,022 - 10,305,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,307 - 10,306,021 (-)NCBICHM1_1
T2T-CHM13v2.01910,259,569 - 10,321,116 (-)NCBIT2T-CHM13v2.0
Dnmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)EnsemblGRCm39 Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBIMGSCv36mm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Dnmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,716,797 - 27,763,405 (-)NCBIGRCr8
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,459,969 - 23,505,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,757,816 - 21,803,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,670,294 - 19,716,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
Dnmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
DNMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,872,213 - 50,928,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,879,527 - 50,928,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,741,748 - 50,797,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,393,895 - 51,450,128 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,401,720 - 51,450,127 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,599,735 - 50,657,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,028,945 - 51,085,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,269,676 - 51,325,956 (+)NCBIUU_Cfam_GSD_1.0
Dnmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,789,213 - 209,834,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659520,493 - 565,416 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659520,181 - 565,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,981,566 - 69,029,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,981,564 - 69,040,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,309,511 - 69,357,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,199,006 - 9,263,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,199,003 - 9,263,607 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,795,260 - 10,857,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000031198   ⟹   ENSPPAP00000008562
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1910,342,478 - 10,390,397 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000031232   ⟹   ENSPPAP00000008596
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1910,342,800 - 10,406,972 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000031240   ⟹   ENSPPAP00000008604
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1910,343,198 - 10,406,972 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000031243   ⟹   ENSPPAP00000008607
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1910,343,198 - 10,406,972 (-)Ensembl
RefSeq Acc Id: XM_034944112   ⟹   XP_034800003
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBI
Mhudiblu_PPA_v0199,681,847 - 9,745,283 (-)NCBI
RefSeq Acc Id: XM_034944113   ⟹   XP_034800004
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,453 (-)NCBI
Mhudiblu_PPA_v0199,681,861 - 9,745,281 (-)NCBI
RefSeq Acc Id: XM_034944115   ⟹   XP_034800006
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,454 (-)NCBI
Mhudiblu_PPA_v0199,681,861 - 9,745,280 (-)NCBI
RefSeq Acc Id: XM_034944116   ⟹   XP_034800007
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,452 (-)NCBI
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBI
RefSeq Acc Id: XM_055103440   ⟹   XP_054959415
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,455 (-)NCBI
RefSeq Acc Id: XM_055103441   ⟹   XP_054959416
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
NHGRI_mPanPan11914,048,694 - 14,110,455 (-)NCBI
RefSeq Acc Id: XM_063599860   ⟹   XP_063455930
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
RefSeq Acc Id: XM_063599861   ⟹   XP_063455931
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
RefSeq Acc Id: XM_063599862   ⟹   XP_063455932
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
RefSeq Acc Id: XM_063599863   ⟹   XP_063455933
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22015,048,374 - 15,111,880 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034800007   ⟸   XM_034944116
- Peptide Label: isoform X10
RefSeq Acc Id: XP_034800003   ⟸   XM_034944112
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034800004   ⟸   XM_034944113
- Peptide Label: isoform X8
RefSeq Acc Id: XP_034800006   ⟸   XM_034944115
- Peptide Label: isoform X9
RefSeq Acc Id: ENSPPAP00000008562   ⟸   ENSPPAT00000031198
RefSeq Acc Id: ENSPPAP00000008604   ⟸   ENSPPAT00000031240
RefSeq Acc Id: ENSPPAP00000008607   ⟸   ENSPPAT00000031243
RefSeq Acc Id: ENSPPAP00000008596   ⟸   ENSPPAT00000031232
RefSeq Acc Id: XP_054959415   ⟸   XM_055103440
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054959416   ⟸   XM_055103441
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063455933   ⟸   XM_063599863
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063455932   ⟸   XM_063599862
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063455931   ⟸   XM_063599861
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063455930   ⟸   XM_063599860
- Peptide Label: isoform X1
Protein Domains
BAH   CXXC-type   DMAP1-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000031198.1 UniProtKB/TrEMBL
  ENSPPAT00000031232.1 UniProtKB/TrEMBL
  ENSPPAT00000031240.1 UniProtKB/TrEMBL
  ENSPPAT00000031243.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2230 UniProtKB/TrEMBL
  2.30.30.490 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  DNA Methylase, subunit A, domain 2 UniProtKB/TrEMBL
InterPro BAH_dom UniProtKB/TrEMBL
  BAH_sf UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  C5_meth_CS UniProtKB/TrEMBL
  Cytosine_MeTrfase1_RFD UniProtKB/TrEMBL
  DMAP1-bd UniProtKB/TrEMBL
  DNMT1-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
NCBI Gene DNMT1 ENTREZGENE
PANTHER CYTOSINE-SPECIFIC METHYLTRANSFERASE UniProtKB/TrEMBL
  DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 UniProtKB/TrEMBL
  DNA (CYTOSINE-5)-METHYLTRANSFERASE CMT1-RELATED UniProtKB/TrEMBL
Pfam BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
  DNMT1-RFD UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PIRSF DNMT1 UniProtKB/TrEMBL
PRINTS C5METTRFRASE UniProtKB/TrEMBL
PROSITE BAH UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/TrEMBL
  C5_MTASE_2 UniProtKB/TrEMBL
  DMAP1_BIND UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
SMART BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A2R8ZUG2_PANPA UniProtKB/TrEMBL
  A0A2R8ZVL6_PANPA UniProtKB/TrEMBL
  A0A2R8ZXP9_PANPA UniProtKB/TrEMBL
  A0A2R8ZXU4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 DNMT1  DNA methyltransferase 1  LOC103784648  DNA (cytosine-5)-methyltransferase 1-like  Data merged from RGD:11863533 737654 PROVISIONAL