OXSR1 (oxidative stress responsive kinase 1) - Rat Genome Database

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Gene: OXSR1 (oxidative stress responsive kinase 1) Pan paniscus
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Symbol: OXSR1
Name: oxidative stress responsive kinase 1
RGD ID: 11845961
Description: ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); histone H2AS1 kinase activity (inferred); INVOLVED IN cell volume homeostasis (inferred); cellular hyperosmotic response (inferred); cellular hypotonic response (inferred); ASSOCIATED WITH Brugada syndrome (ortholog); hypertension (ortholog); Immunodeficiency 68 (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: oxidative stress responsive 1; serine/threonine-protein kinase OSR1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,115,759 - 38,209,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,120,761 - 38,213,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,345,491 - 38,436,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OXSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,115,759 - 38,209,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,120,761 - 38,213,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,345,491 - 38,436,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensemblpanpan1.1panPan2
OXSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,164,063 - 38,255,484 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,165,089 - 38,255,484 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,207,028 - 38,296,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,182,030 - 38,271,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,182,029 - 38,271,979NCBI
Celera338,142,644 - 38,232,606 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,248,039 - 38,338,925 (+)NCBIHuRef
CHM1_1338,158,703 - 38,248,663 (+)NCBICHM1_1
T2T-CHM13v2.0338,170,735 - 38,261,199 (+)NCBIT2T-CHM13v2.0
Oxsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,067,498 - 119,151,493 (-)EnsemblGRCm39 Ensembl
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBIMGSCv36mm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Oxsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,850,481 - 127,941,518 (-)NCBIGRCr8
mRatBN7.28118,972,754 - 119,062,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,972,754 - 119,062,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,554,616 - 124,644,062 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,753,635 - 122,843,081 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,586,701 - 120,676,604 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,920,349 - 128,009,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,127,110 - 127,216,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,196,599 - 124,286,647 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,217,575 - 124,306,410 (-)NCBI
Celera8118,123,990 - 118,213,225 (-)NCBICelera
Cytogenetic Map8q32NCBI
Oxsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,575,655 - 25,696,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,575,655 - 25,696,356 (+)NCBIChiLan1.0ChiLan1.0
OXSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,931,636 - 8,026,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,932,254 - 8,024,323 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,973,576 - 8,067,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,221,226 - 8,313,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,221,839 - 8,315,902 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,035,117 - 8,130,106 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,175,999 - 8,270,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,168,533 - 8,263,795 (+)NCBIUU_Cfam_GSD_1.0
Oxsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,421,183 - 194,519,453 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,559,752 - 27,658,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,559,756 - 27,658,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,020,530 - 23,116,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,020,839 - 23,116,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,225,156 - 25,288,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OXSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,164,529 - 1,255,935 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,164,528 - 1,255,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,895,779 - 9,985,796 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxsr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,703,301 - 2,826,419 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,703,295 - 2,825,017 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000033381   ⟹   ENSPPAP00000010728
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033383   ⟹   ENSPPAP00000010730
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl338,345,843 - 38,374,198 (+)Ensembl
RefSeq Acc Id: XM_003826097   ⟹   XP_003826145
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,115,759 - 38,209,133 (+)NCBI
NHGRI_mPanPan1338,123,489 - 38,213,897 (+)NCBI
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBI
PanPan1.1338,345,504 - 38,436,275 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055109658   ⟹   XP_054965633
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,115,759 - 38,209,133 (+)NCBI
NHGRI_mPanPan1338,120,761 - 38,213,897 (+)NCBI
RefSeq Acc Id: XM_055109659   ⟹   XP_054965634
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,130,900 - 38,209,133 (+)NCBI
NHGRI_mPanPan1338,135,664 - 38,213,897 (+)NCBI
RefSeq Acc Id: XM_055109660   ⟹   XP_054965635
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,146,954 - 38,209,133 (+)NCBI
NHGRI_mPanPan1338,151,718 - 38,213,897 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003826145 (Get FASTA)   NCBI Sequence Viewer  
  XP_054965633 (Get FASTA)   NCBI Sequence Viewer  
  XP_054965634 (Get FASTA)   NCBI Sequence Viewer  
  XP_054965635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010728.1
  ENSPPAP00000010730.1
RefSeq Acc Id: XP_003826145   ⟸   XM_003826097
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A1K9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000010730   ⟸   ENSPPAT00000033383
Ensembl Acc Id: ENSPPAP00000010728   ⟸   ENSPPAT00000033381
RefSeq Acc Id: XP_054965633   ⟸   XM_055109658
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A1K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054965634   ⟸   XM_055109659
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A1K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054965635   ⟸   XM_055109660
- Peptide Label: isoform X4
- UniProtKB: A0A2R9A1K9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033381.1 UniProtKB/TrEMBL
  ENSPPAT00000033383.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/TrEMBL
KEGG Report pps:100995811 UniProtKB/TrEMBL
NCBI Gene OXSR1 ENTREZGENE
PANTHER PTHR48012:SF1 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9A1K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A600_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-23 OXSR1  oxidative stress responsive kinase 1    oxidative stress responsive 1  Symbol and/or name change 5135510 APPROVED