LMNA (lamin A/C) - Rat Genome Database
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Gene: LMNA (lamin A/C) Pan paniscus
Analyze
Symbol: LMNA
Name: lamin A/C
RGD ID: 11845628
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein phosphatase 1 binding (ortholog); INVOLVED IN cellular protein localization (ortholog); cellular response to hypoxia (ortholog); cellular senescence (ortholog); PARTICIPATES IN atherosclerosis pathway; ASSOCIATED WITH aortic valve disease 2 (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); FOUND IN cytosol (ortholog); lamin filament (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: lamin; prelamin-A/C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (ISO)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (ISO)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
Insulin Resistance  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
lethal restrictive dermopathy  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Mandibuloacral Dysplasia with Type A Lipodystrophy  (ISO)
Metabolic Syndrome  (ISO)
muscular dystrophy  (ISO)
neuritis  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (ISO)
Progeria Syndrome, Childhood-Onset  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LMNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0panPan3
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1156,082,573 - 156,140,089 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1156,082,573 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,449 - 157,505,990 (+)NCBICHM1_1
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBImm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBI
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lmna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,290,037 - 2,313,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,290,076 - 2,310,982 (+)NCBIChiLan1.0ChiLan1.0
LMNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl741,508,450 - 41,746,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1741,702,491 - 41,719,870 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lmna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365805,374,208 - 5,395,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,899,026 - 93,949,398 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,899,019 - 93,927,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,641,459 - 102,668,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4qNCBI
LMNA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,723,059 - 7,748,799 (-)NCBI
ChlSab1.1 Ensembl207,723,477 - 7,748,780 (-)Ensembl
Lmna
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,423,563 - 1,466,657 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034937332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000052850   ⟹   ENSPPAP00000029995
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052872   ⟹   ENSPPAP00000030016
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,285,593 - 135,310,562 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052883   ⟹   ENSPPAP00000030027
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,285,593 - 135,309,213 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052910   ⟹   ENSPPAP00000030053
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,285,593 - 135,309,213 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052922   ⟹   ENSPPAP00000030065
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,297,162 - 135,311,297 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052927   ⟹   ENSPPAP00000030070
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,297,761 - 135,309,213 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052934   ⟹   ENSPPAP00000030077
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1135,300,768 - 135,310,562 (+)Ensembl
RefSeq Acc Id: XM_034937332   ⟹   XP_034793223
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034793223 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034793223   ⟸   XM_034937332
RefSeq Acc Id: ENSPPAP00000029995   ⟸   ENSPPAT00000052850
RefSeq Acc Id: ENSPPAP00000030016   ⟸   ENSPPAT00000052872
RefSeq Acc Id: ENSPPAP00000030027   ⟸   ENSPPAT00000052883
RefSeq Acc Id: ENSPPAP00000030077   ⟸   ENSPPAT00000052934
RefSeq Acc Id: ENSPPAP00000030053   ⟸   ENSPPAT00000052910
RefSeq Acc Id: ENSPPAP00000030065   ⟸   ENSPPAT00000052922
RefSeq Acc Id: ENSPPAP00000030070   ⟸   ENSPPAT00000052927
Protein Domains
IF rod   LTD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000029995 UniProtKB/TrEMBL
  ENSPPAP00000030016 UniProtKB/TrEMBL
  ENSPPAP00000030027 UniProtKB/TrEMBL
  ENSPPAP00000030053 UniProtKB/TrEMBL
  ENSPPAP00000030065 UniProtKB/TrEMBL
  ENSPPAP00000030070 UniProtKB/TrEMBL
  ENSPPAP00000030077 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052850 UniProtKB/TrEMBL
  ENSPPAT00000052872 UniProtKB/TrEMBL
  ENSPPAT00000052883 UniProtKB/TrEMBL
  ENSPPAT00000052910 UniProtKB/TrEMBL
  ENSPPAT00000052922 UniProtKB/TrEMBL
  ENSPPAT00000052927 UniProtKB/TrEMBL
  ENSPPAT00000052934 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1160 UniProtKB/TrEMBL
  2.60.40.1260 UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  IF_rod_dom_coil1B UniProtKB/TrEMBL
  Lamin_tail_dom UniProtKB/TrEMBL
  Lamin_tail_dom_sf UniProtKB/TrEMBL
NCBI Gene LMNA ENTREZGENE
Pfam Filament UniProtKB/TrEMBL
  LTD UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
  LTD UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP SSF74853 UniProtKB/TrEMBL
UniProt A0A2R9BK07_PANPA UniProtKB/TrEMBL
  A0A2R9BK76_PANPA UniProtKB/TrEMBL
  A0A2R9BK80_PANPA UniProtKB/TrEMBL
  A0A2R9BKX5_PANPA UniProtKB/TrEMBL
  A0A2R9BNK9_PANPA UniProtKB/TrEMBL
  A0A2R9BNQ7_PANPA UniProtKB/TrEMBL
  A0A2R9BTW3_PANPA UniProtKB/TrEMBL