NPC1L1 (NPC1 like intracellular cholesterol transporter 1) - Rat Genome Database

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Gene: NPC1L1 (NPC1 like intracellular cholesterol transporter 1) Pan paniscus
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Symbol: NPC1L1
Name: NPC1 like intracellular cholesterol transporter 1
RGD ID: 11845189
Description: ENCODES a protein that exhibits heterocyclic compound binding (ortholog); myosin V binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to sterol depletion (ortholog); cholesterol biosynthetic process (ortholog); cholesterol homeostasis (ortholog); ASSOCIATED WITH arteriosclerosis (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Niemann-Pick C1-like protein 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1-like intracellular cholesterol transporter 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,424,993 - 49,453,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,749,732 - 97,778,483 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,227,289 - 45,256,094 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,296,365 - 45,324,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,297,271 - 45,324,692 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPC1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,424,993 - 49,453,745 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,749,732 - 97,778,483 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,227,289 - 45,256,094 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,296,365 - 45,324,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,297,271 - 45,324,692 (-)Ensemblpanpan1.1panPan2
NPC1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,512,535 - 44,541,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,512,535 - 44,541,330 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,552,134 - 44,580,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,518,659 - 44,547,439 (-)NCBINCBI36Build 36hg18NCBI36
Build 34744,325,376 - 44,354,154NCBI
Celera744,651,139 - 44,679,899 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,436,243 - 44,465,023 (-)NCBIHuRef
CHM1_1744,556,489 - 44,585,261 (-)NCBICHM1_1
T2T-CHM13v2.0744,672,255 - 44,701,030 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,591,658 - 44,620,428 (-)NCBI
Npc1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,161,011 - 6,180,245 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,161,013 - 6,180,143 (-)EnsemblGRCm39 Ensembl
GRCm38116,211,011 - 6,230,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,211,013 - 6,230,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,111,014 - 6,130,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,111,461 - 6,130,126 (-)NCBIMGSCv36mm8
Celera116,693,602 - 6,712,842 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.93NCBI
Npc1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,285,387 - 85,305,050 (-)NCBIGRCr8
mRatBN7.21481,071,448 - 81,091,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,071,451 - 81,091,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,472,534 - 85,492,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,712,619 - 86,732,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,161,944 - 83,181,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,345,946 - 86,560,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,345,953 - 86,560,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,307,372 - 87,319,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01487,516,291 - 87,523,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1479,954,434 - 79,974,086 (-)NCBICelera
Cytogenetic Map14q21NCBI
Npc1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,528,423 - 7,547,720 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,528,452 - 7,547,714 (+)NCBIChiLan1.0ChiLan1.0
NPC1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,311,494 - 2,327,591 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,518,743 - 14,550,434 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,534,022 - 14,550,425 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,165,465 - 14,181,751 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,146,247 - 14,162,328 (+)NCBIUU_Cfam_GSD_1.0
Npc1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,222,063 - 100,240,594 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,434,557 - 19,452,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,434,557 - 19,452,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,726,922 - 50,757,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,726,854 - 50,757,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,630,239 - 55,657,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPC1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,129,413 - 14,163,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,130,767 - 14,163,907 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,377,157 - 8,405,655 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npc1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,590,046 - 7,609,420 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,590,041 - 7,609,574 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000034824   ⟹   ENSPPAP00000012162
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,297,271 - 45,324,637 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034827   ⟹   ENSPPAP00000012165
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,297,271 - 45,324,637 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034828   ⟹   ENSPPAP00000012166
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,297,271 - 45,324,637 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034832   ⟹   ENSPPAP00000012170
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,297,271 - 45,324,637 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034838   ⟹   ENSPPAP00000012176
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,297,271 - 45,323,627 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034845   ⟹   ENSPPAP00000012183
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl745,316,614 - 45,324,692 (-)Ensembl
RefSeq Acc Id: XM_034964032   ⟹   XP_034819923
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2649,424,993 - 49,453,745 (-)NCBI
NHGRI_mPanPan1797,749,732 - 97,778,483 (-)NCBI
Mhudiblu_PPA_v0745,227,289 - 45,256,023 (-)NCBI
RefSeq Acc Id: XM_055115897   ⟹   XP_054971872
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2649,424,993 - 49,453,745 (-)NCBI
NHGRI_mPanPan1797,749,732 - 97,778,483 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034819923 (Get FASTA)   NCBI Sequence Viewer  
  XP_054971872 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012162.1
  ENSPPAP00000012165.1
  ENSPPAP00000012166.1
  ENSPPAP00000012170.1
  ENSPPAP00000012176.1
  ENSPPAP00000012183.1
RefSeq Acc Id: XP_034819923   ⟸   XM_034964032
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A4D2 (UniProtKB/TrEMBL),   A0A2R9A944 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000012176   ⟸   ENSPPAT00000034838
RefSeq Acc Id: ENSPPAP00000012170   ⟸   ENSPPAT00000034832
RefSeq Acc Id: ENSPPAP00000012166   ⟸   ENSPPAT00000034828
RefSeq Acc Id: ENSPPAP00000012162   ⟸   ENSPPAT00000034824
RefSeq Acc Id: ENSPPAP00000012165   ⟸   ENSPPAT00000034827
RefSeq Acc Id: ENSPPAP00000012183   ⟸   ENSPPAT00000034845
RefSeq Acc Id: XP_054971872   ⟸   XM_055115897
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A9R0 (UniProtKB/TrEMBL),   A0A2R9A944 (UniProtKB/TrEMBL)
Protein Domains
SSD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034824.1 UniProtKB/TrEMBL
  ENSPPAT00000034827.1 UniProtKB/TrEMBL
  ENSPPAT00000034828.1 UniProtKB/TrEMBL
  ENSPPAT00000034832.1 UniProtKB/TrEMBL
  ENSPPAT00000034838.1 UniProtKB/TrEMBL
  ENSPPAT00000034845.1 UniProtKB/TrEMBL
Gene3D-CATH Multidrug efflux transporter AcrB transmembrane domain UniProtKB/TrEMBL
InterPro NPC1-like UniProtKB/TrEMBL
  NPC1_N UniProtKB/TrEMBL
  Ptc/Disp UniProtKB/TrEMBL
  SSD UniProtKB/TrEMBL
NCBI Gene NPC1L1 ENTREZGENE
PANTHER NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 UniProtKB/TrEMBL
  NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1 UniProtKB/TrEMBL
Pfam NPC1_N UniProtKB/TrEMBL
  Patched UniProtKB/TrEMBL
  Sterol-sensing UniProtKB/TrEMBL
PROSITE SSD UniProtKB/TrEMBL
Superfamily-SCOP Multidrug efflux transporter AcrB transmembrane domain UniProtKB/TrEMBL
UniProt A0A2R9A4D2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A4G3_PANPA UniProtKB/TrEMBL
  A0A2R9A944 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A950_PANPA UniProtKB/TrEMBL
  A0A2R9A9R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A9S1_PANPA UniProtKB/TrEMBL