TRIM21 (tripartite motif containing 21) - Rat Genome Database

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Gene: TRIM21 (tripartite motif containing 21) Pan paniscus
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Symbol: TRIM21
Name: tripartite motif containing 21
RGD ID: 11833404
Description: ENCODES a protein that exhibits identical protein binding (inferred); metal ion binding (inferred); protein homodimerization activity (inferred); INVOLVED IN innate immune response (inferred); negative regulation of innate immune response (inferred); negative regulation of protein deubiquitination (inferred); ASSOCIATED WITH delta beta-thalassemia (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic stress granule (ortholog); SCF ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase TRIM21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v296,874,977 - 6,883,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,831,784 - 6,840,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,588,083 - 4,596,942 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1114,254,152 - 4,262,981 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl114,254,152 - 4,262,981 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRIM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v296,874,977 - 6,883,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,831,784 - 6,840,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,588,083 - 4,596,942 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1114,254,152 - 4,262,981 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl114,254,152 - 4,262,981 (-)Ensemblpanpan1.1panPan2
TRIM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38114,384,897 - 4,393,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl114,384,897 - 4,393,702 (-)EnsemblGRCh38hg38GRCh38
GRCh37114,406,127 - 4,414,932 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36114,362,703 - 4,371,502 (-)NCBINCBI36Build 36hg18NCBI36
Build 34114,362,702 - 4,371,502NCBI
Celera114,530,327 - 4,539,126 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef114,064,388 - 4,073,231 (-)NCBIHuRef
CHM1_1114,406,038 - 4,414,832 (-)NCBICHM1_1
T2T-CHM13v2.0114,449,988 - 4,458,819 (-)NCBIT2T-CHM13v2.0
Trim21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397102,207,127 - 102,214,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7102,207,128 - 102,214,693 (-)EnsemblGRCm39 Ensembl
GRCm387102,557,920 - 102,565,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,557,921 - 102,565,486 (-)EnsemblGRCm38mm10GRCm38
MGSCv377109,706,436 - 109,713,983 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,431,745 - 102,439,243 (-)NCBIMGSCv36mm8
Celera7102,922,872 - 102,930,525 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map754.76NCBI
Trim21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,376,829 - 166,399,441 (-)NCBIGRCr8
mRatBN7.21156,964,896 - 156,987,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,964,913 - 156,987,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,945,281 - 164,956,667 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,125,359 - 172,136,745 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,032,224 - 165,043,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,686,148 - 167,708,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,686,173 - 167,708,714 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,871,557 - 173,894,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41160,175,882 - 160,187,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11160,254,898 - 160,276,114 (-)NCBI
Celera1155,032,978 - 155,043,976 (-)NCBICelera
Cytogenetic Map1q32NCBI
Trim21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541420,070,359 - 20,077,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541420,066,109 - 20,077,331 (-)NCBIChiLan1.0ChiLan1.0
TRIM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,775,227 - 26,783,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,775,672 - 26,783,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,545,768 - 26,553,727 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02127,008,568 - 27,016,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2127,008,572 - 27,016,482 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,775,451 - 26,783,414 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02127,014,746 - 27,022,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,901,794 - 26,909,757 (-)NCBIUU_Cfam_GSD_1.0
Trim21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,090,839 - 59,097,841 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936498690,480 - 699,890 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936498690,481 - 697,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl95,782,200 - 5,791,577 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.195,782,133 - 5,790,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.296,536,099 - 6,544,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,451,808 - 62,460,658 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,451,830 - 62,460,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604363,449,436 - 63,458,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trim21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248175,639,779 - 5,653,361 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,643,788 - 5,651,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003804657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000064430   ⟹   ENSPPAP00000041504
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl114,254,152 - 4,262,981 (-)Ensembl
RefSeq Acc Id: XM_003804657   ⟹   XP_003804705
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v296,874,977 - 6,883,831 (-)NCBI
NHGRI_mPanPan1116,831,784 - 6,840,633 (-)NCBI
Mhudiblu_PPA_v0114,588,083 - 4,596,942 (-)NCBI
PanPan1.1114,254,152 - 4,262,981 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003804705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000041504
  ENSPPAP00000041504.1
RefSeq Acc Id: XP_003804705   ⟸   XM_003804657
- UniProtKB: A0A2R9CHV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000041504   ⟸   ENSPPAT00000064430
Protein Domains
B box-type   B30.2/SPRY   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043375 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000064430.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  PRY/SPRY_TRIM21 UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  Ubox_domain UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
  Znf_B-box_chordata UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report pps:100980445 UniProtKB/TrEMBL
NCBI Gene TRIM21 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE TRIM21 UniProtKB/TrEMBL
Pfam PRY UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  zf-B_box UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/TrEMBL
PRINTS BBOXZNFINGER UniProtKB/TrEMBL
  BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BBOX UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  Ubox UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A2R9CHV1 ENTREZGENE, UniProtKB/TrEMBL