MLST8 (MTOR associated protein, LST8 homolog) - Rat Genome Database

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Gene: MLST8 (MTOR associated protein, LST8 homolog) Pan paniscus
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Symbol: MLST8
Name: MTOR associated protein, LST8 homolog
RGD ID: 11832530
Description: ENCODES a protein that exhibits protein serine/threonine kinase activator activity (inferred); INVOLVED IN positive regulation of actin filament polymerization (ortholog); positive regulation of peptidyl-tyrosine phosphorylation (ortholog); PARTICIPATES IN mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); developmental and epileptic encephalopathy 1 (ortholog); endometrial carcinoma (ortholog); FOUND IN TORC1 complex (ortholog); TORC2 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: target of rapamycin complex subunit LST8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,707,554 - 2,712,302 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,488,454 - 6,493,202 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,063,534 - 1,067,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,306,451 - 2,310,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,306,451 - 2,310,828 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
lysosomal membrane  (IEA)
TORC1 complex  (IEA,ISO)
TORC2 complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MLST8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,707,554 - 2,712,302 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,488,454 - 6,493,202 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,063,534 - 1,067,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,306,451 - 2,310,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,306,451 - 2,310,828 (+)Ensemblpanpan1.1panPan2
MLST8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,205,454 - 2,209,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,204,248 - 2,209,453 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,255,455 - 2,259,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,195,451 - 2,199,419 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,195,495 - 2,199,414NCBI
Celera162,469,868 - 2,473,835 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,181,357 - 2,185,596 (+)NCBIHuRef
CHM1_1162,255,106 - 2,259,344 (+)NCBICHM1_1
T2T-CHM13v2.0162,227,913 - 2,231,910 (+)NCBIT2T-CHM13v2.0
Mlst8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,692,524 - 24,698,722 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,692,525 - 24,698,052 (-)EnsemblGRCm39 Ensembl
GRCm381724,473,550 - 24,479,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,473,551 - 24,479,078 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,610,496 - 24,616,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,201,153 - 24,206,678 (-)NCBIMGSCv36mm8
Celera1724,989,327 - 24,994,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.39NCBI
Mlst8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,002,927 - 14,008,678 (-)NCBIGRCr8
mRatBN7.21013,498,377 - 13,504,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,498,388 - 13,504,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,244,945 - 18,250,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,733,790 - 17,739,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,232,975 - 13,238,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,839,250 - 13,845,001 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,839,250 - 13,845,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,656,236 - 13,661,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,725,510 - 13,731,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,725,520 - 13,731,261 (-)NCBI
Celera1013,178,857 - 13,184,608 (-)NCBICelera
Cytogenetic Map10q12NCBI
Mlst8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,056,363 - 15,060,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,056,363 - 15,060,300 (-)NCBIChiLan1.0ChiLan1.0
MLST8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,759,713 - 38,765,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,762,103 - 38,765,488 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,999,004 - 40,004,847 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,068,199 - 39,074,042 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,068,201 - 39,073,985 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,753,209 - 38,759,052 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,725,535 - 38,731,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,204,256 - 39,210,099 (-)NCBIUU_Cfam_GSD_1.0
Mlst8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,859,878 - 104,872,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,834,701 - 1,842,719 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,839,135 - 1,849,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLST8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,778,754 - 39,788,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,778,746 - 39,786,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,394,842 - 42,398,552 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MLST8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,101,044 - 2,105,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,101,891 - 2,105,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,956,518 - 28,960,758 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlst8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462491347,962 - 55,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462491350,622 - 54,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000043100   ⟹   ENSPPAP00000020308
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl162,306,451 - 2,310,828 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000043112   ⟹   ENSPPAP00000020320
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl162,307,521 - 2,310,142 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000043117   ⟹   ENSPPAP00000020325
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl162,307,521 - 2,309,879 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000043119   ⟹   ENSPPAP00000020327
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl162,307,521 - 2,308,678 (+)Ensembl
RefSeq Acc Id: XM_003806216   ⟹   XP_003806264
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2182,707,554 - 2,712,302 (+)NCBI
NHGRI_mPanPan1166,488,454 - 6,493,202 (+)NCBI
Mhudiblu_PPA_v0161,063,534 - 1,067,706 (+)NCBI
PanPan1.1162,306,451 - 2,310,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008951330   ⟹   XP_008949578
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2182,707,579 - 2,712,302 (+)NCBI
NHGRI_mPanPan1166,488,479 - 6,493,202 (+)NCBI
Mhudiblu_PPA_v0161,063,536 - 1,067,706 (+)NCBI
PanPan1.1162,306,451 - 2,310,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063598257   ⟹   XP_063454327
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2182,707,555 - 2,712,302 (+)NCBI
RefSeq Acc Id: XM_063598258   ⟹   XP_063454328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2182,708,393 - 2,712,302 (+)NCBI
RefSeq Acc Id: XP_008949578   ⟸   XM_008951330
- UniProtKB: A0A2R9ASY7 (UniProtKB/TrEMBL),   A0A2R9AWZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003806264   ⟸   XM_003806216
- UniProtKB: A0A2R9ASY7 (UniProtKB/TrEMBL),   A0A2R9AWZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000020308   ⟸   ENSPPAT00000043100
RefSeq Acc Id: ENSPPAP00000020325   ⟸   ENSPPAT00000043117
RefSeq Acc Id: ENSPPAP00000020327   ⟸   ENSPPAT00000043119
RefSeq Acc Id: ENSPPAP00000020320   ⟸   ENSPPAT00000043112
RefSeq Acc Id: XP_063454327   ⟸   XM_063598257
RefSeq Acc Id: XP_063454328   ⟸   XM_063598258


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043100.1 UniProtKB/TrEMBL
  ENSPPAT00000043112.1 UniProtKB/TrEMBL
  ENSPPAT00000043117.1 UniProtKB/TrEMBL
  ENSPPAT00000043119.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  MLST8 UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100976275 UniProtKB/TrEMBL
NCBI Gene MLST8 ENTREZGENE
PANTHER PTHR19842 UniProtKB/TrEMBL
  TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF50998 UniProtKB/TrEMBL
UniProt A0A2R9ASL1_PANPA UniProtKB/TrEMBL
  A0A2R9ASY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AWZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AWZ5_PANPA UniProtKB/TrEMBL