DUOX1 (dual oxidase 1) - Rat Genome Database

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Gene: DUOX1 (dual oxidase 1) Pan paniscus
Analyze
Symbol: DUOX1
Name: dual oxidase 1
RGD ID: 11826713
Description: ENCODES a protein that exhibits calcium ion binding (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN reactive oxygen species metabolic process (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN apical plasma membrane (inferred); cell leading edge (inferred); cell surface (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11542,432,792 - 42,466,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,431,595 - 42,467,943 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01524,077,557 - 24,113,206 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
DUOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11542,432,792 - 42,466,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,431,595 - 42,467,943 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01524,077,557 - 24,113,206 (+)NCBIMhudiblu_PPA_v0panPan3
DUOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,129,994 - 45,165,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1545,129,933 - 45,165,576 (+)EnsemblGRCh38hg38GRCh38
GRCh371545,422,192 - 45,457,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,209,484 - 43,245,066 (+)NCBINCBI36hg18NCBI36
Build 341543,209,483 - 43,245,066NCBI
Celera1522,313,628 - 22,349,058 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1522,246,405 - 22,281,983 (+)NCBIHuRef
CHM1_11545,540,525 - 45,576,452 (+)NCBICHM1_1
T2T-CHM13v2.01542,938,016 - 42,973,584 (+)NCBI
Duox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,143,525 - 122,178,454 (+)NCBIGRCm39mm39
GRCm39 Ensembl2122,146,153 - 122,178,453 (+)Ensembl
GRCm382122,313,010 - 122,347,972 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,315,672 - 122,347,972 (+)EnsemblGRCm38mm10GRCm38
MGSCv372122,141,408 - 122,173,708 (+)NCBIGRCm37mm9NCBIm37
MGSCv362122,005,116 - 122,039,413 (+)NCBImm8
MGSCv362123,286,960 - 123,321,338 (+)NCBImm8
Celera2123,465,585 - 123,497,811 (+)NCBICelera
Cytogenetic Map2E5NCBI
Duox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,260,526 - 109,295,588 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3109,262,397 - 109,295,563 (+)Ensembl
Rnor_6.03114,251,794 - 114,286,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,253,637 - 114,286,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,791,108 - 120,826,222 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,095,250 - 109,128,415 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13109,000,832 - 109,033,988 (+)NCBI
Celera3108,160,238 - 108,192,976 (+)NCBICelera
Cytogenetic Map3q35NCBI
Duox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,229,199 - 8,255,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,228,754 - 8,256,575 (-)NCBIChiLan1.0ChiLan1.0
DUOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,556,024 - 11,588,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,556,024 - 11,588,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,612,190 - 11,644,063 (+)NCBI
ROS_Cfam_1.03011,692,796 - 11,724,747 (+)NCBI
ROS_Cfam_1.0 Ensembl3011,692,815 - 11,724,746 (+)Ensembl
UMICH_Zoey_3.13011,599,266 - 11,631,208 (+)NCBI
UNSW_CanFamBas_1.03011,721,544 - 11,753,719 (+)NCBI
UU_Cfam_GSD_1.03011,841,362 - 11,873,559 (+)NCBI
Duox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,998,522 - 90,032,014 (+)NCBI
SpeTri2.0NW_0049364717,848,472 - 7,881,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,572,492 - 126,620,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,572,533 - 126,603,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,171,519 - 141,206,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,038,093 - 38,073,993 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,038,771 - 38,072,023 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048102,986,753 - 103,021,591 (+)NCBIVero_WHO_p1.0
Duox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,081,245 - 14,107,104 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473114,080,670 - 14,107,532 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059240   ⟹   ENSPPAP00000036348
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,431,595 - 42,467,943 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059264   ⟹   ENSPPAP00000036372
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,431,595 - 42,467,943 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059299   ⟹   ENSPPAP00000036407
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,432,841 - 42,465,769 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059303   ⟹   ENSPPAP00000036411
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,432,841 - 42,441,906 (+)Ensembl
RefSeq Acc Id: XM_008961934   ⟹   XP_008960182
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11542,432,792 - 42,466,446 (+)NCBI
Mhudiblu_PPA_v01524,077,589 - 24,113,206 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034938681   ⟹   XP_034794572
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01524,077,705 - 24,113,204 (+)NCBI
RefSeq Acc Id: XM_034938682   ⟹   XP_034794573
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01524,077,557 - 24,113,201 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008960182 (Get FASTA)   NCBI Sequence Viewer  
  XP_034794572 (Get FASTA)   NCBI Sequence Viewer  
  XP_034794573 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008960182   ⟸   XM_008961934
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034794573   ⟸   XM_034938682
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034794572   ⟸   XM_034938681
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000036411   ⟸   ENSPPAT00000059303
RefSeq Acc Id: ENSPPAP00000036348   ⟸   ENSPPAT00000059240
RefSeq Acc Id: ENSPPAP00000036407   ⟸   ENSPPAT00000059299
RefSeq Acc Id: ENSPPAP00000036372   ⟸   ENSPPAT00000059264
Protein Domains
EF-hand   FAD-binding FR-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040927 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000036348 UniProtKB/TrEMBL
  ENSPPAP00000036372 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000036407 UniProtKB/TrEMBL
  ENSPPAP00000036411 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059240 UniProtKB/TrEMBL
  ENSPPAT00000059264 UniProtKB/TrEMBL
  ENSPPAT00000059299 UniProtKB/TrEMBL
  ENSPPAT00000059303 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/TrEMBL
InterPro DUOX1/Duox UniProtKB/TrEMBL
  DUOX_peroxidase UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
KEGG Report pps:100974723 UniProtKB/TrEMBL
NCBI Gene DUOX1 ENTREZGENE
PANTHER PTHR11972:SF75 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
  EF-hand_1 UniProtKB/TrEMBL
  FAD_binding_8 UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  FAD_FR UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF48113 UniProtKB/TrEMBL
  SSF52343 UniProtKB/TrEMBL
  SSF63380 UniProtKB/TrEMBL
UniProt A0A2R9C382_PANPA UniProtKB/TrEMBL
  A0A2R9C626_PANPA UniProtKB/TrEMBL
  A0A2R9CDG9_PANPA UniProtKB/TrEMBL
  A0A2R9CDK4_PANPA UniProtKB/TrEMBL