AP2B1 (adaptor related protein complex 2 subunit beta 1) - Rat Genome Database

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Gene: AP2B1 (adaptor related protein complex 2 subunit beta 1) Pan paniscus
Analyze
Symbol: AP2B1
Name: adaptor related protein complex 2 subunit beta 1
RGD ID: 11822970
Description: ENCODES a protein that exhibits clathrin binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aorta development (ortholog); cardiac septum development (ortholog); clathrin coat assembly (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH genetic disease (ortholog); middle cerebral artery infarction (ortholog); peroxisome biogenesis disorder 3A (ortholog); FOUND IN clathrin coat (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 beta 1 subunit; AP-2 complex subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,750,972 - 28,892,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,632,528 - 30,769,787 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,070,132 - 21,208,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,363,115 - 21,501,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,363,121 - 21,501,721 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AP2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,750,972 - 28,892,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,632,528 - 30,769,787 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,070,132 - 21,208,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,363,115 - 21,501,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,363,121 - 21,501,721 (-)Ensemblpanpan1.1panPan2
AP2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,587,322 - 35,726,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,578,046 - 35,726,413 (+)EnsemblGRCh38hg38GRCh38
GRCh371733,914,341 - 34,053,432 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,938,395 - 31,077,549 (+)NCBINCBI36Build 36hg18NCBI36
Build 341730,938,405 - 31,077,541NCBI
Celera1730,824,398 - 30,963,574 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,099,253 - 30,238,599 (+)NCBIHuRef
CHM1_11733,978,907 - 34,118,050 (+)NCBICHM1_1
T2T-CHM13v2.01736,535,193 - 36,674,326 (+)NCBIT2T-CHM13v2.0
Ap2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,189,545 - 83,295,861 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,189,850 - 83,295,861 (+)EnsemblGRCm39 Ensembl
GRCm381183,298,719 - 83,405,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,299,024 - 83,405,035 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,116,199 - 83,218,537 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,118,892 - 83,221,230 (+)NCBIMGSCv36mm8
Celera1192,894,853 - 92,999,587 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
Ap2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,596,925 - 68,702,547 (+)NCBIGRCr8
mRatBN7.21068,099,397 - 68,205,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,099,547 - 68,205,013 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,723,218 - 72,825,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,228,605 - 72,330,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,692,649 - 67,794,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,516,462 - 70,621,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,520,206 - 70,621,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01071,035,406 - 71,067,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01071,068,935 - 71,083,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,386,233 - 71,488,000 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,399,684 - 71,502,555 (+)NCBI
Celera1067,045,800 - 67,146,677 (+)NCBICelera
Cytogenetic Map10q26NCBI
Ap2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,064,220 - 10,175,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,061,021 - 10,175,070 (+)NCBIChiLan1.0ChiLan1.0
AP2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,946,761 - 38,078,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,946,788 - 38,078,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,170,891 - 37,302,120 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,758,380 - 38,889,742 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,756,039 - 38,889,684 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,541,221 - 37,673,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,826,684 - 37,958,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,914,210 - 38,045,500 (-)NCBIUU_Cfam_GSD_1.0
Ap2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,949,807 - 37,069,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,233 - 127,715 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364905,156 - 127,666 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,800,972 - 39,932,643 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,803,105 - 39,940,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AP2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,061,662 - 29,198,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1629,061,568 - 29,201,464 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666075774,355 - 913,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,090,656 - 3,208,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,085,518 - 3,206,930 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000039039   ⟹   ENSPPAP00000016344
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1721,363,121 - 21,501,721 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039044   ⟹   ENSPPAP00000016349
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1721,363,121 - 21,501,721 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039060   ⟹   ENSPPAP00000016365
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1721,488,020 - 21,494,972 (-)Ensembl
RefSeq Acc Id: XM_003817980   ⟹   XP_003818028
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,890,146 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,422 (-)NCBI
Mhudiblu_PPA_v01721,070,132 - 21,208,422 (-)NCBI
PanPan1.11721,363,115 - 21,501,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003817981   ⟹   XP_003818029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,890,154 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,430 (-)NCBI
Mhudiblu_PPA_v01721,070,132 - 21,208,368 (-)NCBI
PanPan1.11721,365,435 - 21,501,494 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971260   ⟹   XP_008969508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,892,336 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,787 (-)NCBI
Mhudiblu_PPA_v01721,070,132 - 21,208,610 (-)NCBI
PanPan1.11721,363,115 - 21,501,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971262   ⟹   XP_008969510
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,892,336 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,787 (-)NCBI
Mhudiblu_PPA_v01721,070,132 - 21,208,610 (-)NCBI
PanPan1.11721,363,115 - 21,501,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055102051   ⟹   XP_054958026
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,890,154 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,430 (-)NCBI
RefSeq Acc Id: XM_055102052   ⟹   XP_054958027
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21928,750,972 - 28,890,154 (-)NCBI
NHGRI_mPanPan11730,632,528 - 30,769,430 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008969510   ⟸   XM_008971262
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AN11 (UniProtKB/TrEMBL),   A0A2R8ZGJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008969508   ⟸   XM_008971260
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AN06 (UniProtKB/TrEMBL),   A0A2R8ZGJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003818028   ⟸   XM_003817980
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AN06 (UniProtKB/TrEMBL),   A0A2R8ZGJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003818029   ⟸   XM_003817981
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AN06 (UniProtKB/TrEMBL),   A0A2R8ZGJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000016349   ⟸   ENSPPAT00000039044
RefSeq Acc Id: ENSPPAP00000016344   ⟸   ENSPPAT00000039039
RefSeq Acc Id: ENSPPAP00000016365   ⟸   ENSPPAT00000039060
RefSeq Acc Id: XP_054958027   ⟸   XM_055102052
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AN11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054958026   ⟸   XM_055102051
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AN11 (UniProtKB/TrEMBL)
Protein Domains
Beta-adaptin appendage C-terminal subdomain   Clathrin adaptor alpha/beta/gamma-adaptin appendage


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000007354 UniProtKB/TrEMBL
  ENSPPAG00000031208 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000008801.1 UniProtKB/TrEMBL
  ENSPPAT00000039039.1 UniProtKB/TrEMBL
  ENSPPAT00000039044.1 UniProtKB/TrEMBL
  ENSPPAT00000039060.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1150 UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/TrEMBL
InterPro AP_beta UniProtKB/TrEMBL
  AP_complex_bsu_1_2_4 UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  B-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  Clathrin_app_Ig-like_sf UniProtKB/TrEMBL
  Clathrin_b-adaptin_app_Ig-like UniProtKB/TrEMBL
  Coatomer/calthrin_app_sub_C UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100970095 UniProtKB/TrEMBL
NCBI Gene AP2B1 ENTREZGENE
PANTHER AP-2 COMPLEX SUBUNIT BETA UniProtKB/TrEMBL
  B2-ADAPT-APP_C DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR11134 UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
  B2-adapt-app_C UniProtKB/TrEMBL
PIRSF AP_complex_beta UniProtKB/TrEMBL
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
  ARM UniProtKB/TrEMBL
  B2-adapt-app_C UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49348 UniProtKB/TrEMBL
  SSF55711 UniProtKB/TrEMBL
UniProt A0A2R8ZGJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AL32_PANPA UniProtKB/TrEMBL
  A0A2R9AN06 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AN11 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 AP2B1  adaptor related protein complex 2 subunit beta 1    adaptor related protein complex 2 beta 1 subunit  Symbol and/or name change 5135510 APPROVED