EEF2 (eukaryotic translation elongation factor 2) - Rat Genome Database

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Gene: EEF2 (eukaryotic translation elongation factor 2) Pan paniscus
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Symbol: EEF2
Name: eukaryotic translation elongation factor 2
RGD ID: 11821032
Description: ENCODES a protein that exhibits 5S rRNA binding (ortholog); actin filament binding (ortholog); p53 binding (ortholog); INVOLVED IN cellular response to brain-derived neurotrophic factor stimulus (ortholog); glial cell proliferation (ortholog); hematopoietic progenitor cell differentiation (ortholog); PARTICIPATES IN mTOR signaling pathway; translation elongation pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); amenorrhea (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: elongation factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,373,315 - 8,382,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,604,824 - 7,614,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,000,608 - 3,009,918 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,950,772 - 3,960,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,950,772 - 3,960,172 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,373,315 - 8,382,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,604,824 - 7,614,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,000,608 - 3,009,918 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,950,772 - 3,960,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,950,772 - 3,960,172 (-)Ensemblpanpan1.1panPan2
EEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,976,056 - 3,985,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,976,056 - 3,985,463 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,976,054 - 3,985,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,927,054 - 3,936,461 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,927,054 - 3,936,446NCBI
Celera193,912,125 - 3,921,537 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,738,145 - 3,747,558 (-)NCBIHuRef
CHM1_1193,974,658 - 3,985,048 (-)NCBICHM1_1
T2T-CHM13v2.0193,954,240 - 3,963,657 (-)NCBIT2T-CHM13v2.0
Eef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,012,465 - 81,018,343 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,012,465 - 81,018,332 (+)EnsemblGRCm39 Ensembl
GRCm381081,176,631 - 81,182,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,176,631 - 81,182,498 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,639,376 - 80,645,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,579,789 - 80,585,625 (+)NCBIMGSCv36mm8
Celera1082,196,988 - 82,202,866 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Eef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,183,836 - 9,196,255 (-)NCBIGRCr8
mRatBN7.278,533,248 - 8,538,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,533,116 - 8,559,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,418,330 - 11,423,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,293,816 - 13,299,086 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,160,262 - 11,165,532 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,401,501 - 11,406,771 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,401,501 - 11,406,771 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,568,907 - 11,574,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,017,061 - 10,022,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,017,060 - 10,022,331 (-)NCBI
Celera76,721,131 - 6,726,401 (-)NCBICelera
Cytogenetic Map7q11NCBI
Eef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,799,922 - 4,807,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,800,103 - 4,807,714 (+)NCBIChiLan1.0ChiLan1.0
EEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,577,413 - 55,586,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,522,213 - 55,586,126 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,303,183 - 55,312,190 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,237,756 - 56,246,765 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,237,827 - 56,246,765 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,293,742 - 55,302,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,775,305 - 55,784,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,973,982 - 55,983,220 (+)NCBIUU_Cfam_GSD_1.0
Eef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,567,040 - 215,575,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,258,309 - 2,266,609 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,259,236 - 2,267,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,747,080 - 74,756,680 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,746,541 - 74,756,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,290,872 - 75,300,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,733,056 - 3,742,526 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,732,425 - 3,742,826 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,504,441 - 4,513,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,601,444 - 5,611,405 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,601,906 - 5,609,978 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003819267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000062283   ⟹   ENSPPAP00000039373
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,950,772 - 3,960,172 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062302   ⟹   ENSPPAP00000039391
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,951,270 - 3,959,455 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062315   ⟹   ENSPPAP00000039404
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl193,951,270 - 3,959,455 (-)Ensembl
RefSeq Acc Id: XM_003819267   ⟹   XP_003819315
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,373,315 - 8,382,823 (-)NCBI
NHGRI_mPanPan1197,604,824 - 7,614,023 (-)NCBI
Mhudiblu_PPA_v0193,000,608 - 3,009,918 (-)NCBI
PanPan1.1193,950,772 - 3,960,200 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003819315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000039373
  ENSPPAP00000039373.1
  ENSPPAP00000039391.1
  ENSPPAP00000039404.1
RefSeq Acc Id: XP_003819315   ⟸   XM_003819267
- UniProtKB: A0A2R9CEE9 (UniProtKB/TrEMBL),   A0A2R9CBT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000039373   ⟸   ENSPPAT00000062283
RefSeq Acc Id: ENSPPAP00000039404   ⟸   ENSPPAT00000062315
RefSeq Acc Id: ENSPPAP00000039391   ⟸   ENSPPAT00000062302
Protein Domains
tr-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042319 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062283.1 UniProtKB/TrEMBL
  ENSPPAT00000062302.1 UniProtKB/TrEMBL
  ENSPPAT00000062315.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
  3.30.70.240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Elongation Factor G (Translational Gtpase), domain 3 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro EFG_II UniProtKB/TrEMBL
  EFG_III/V UniProtKB/TrEMBL
  EFG_V-like UniProtKB/TrEMBL
  EFTu-like_2 UniProtKB/TrEMBL
  G_TR_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  T_Tr_GTP-bd_dom UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  Transl_elong_EFG/EF2_IV UniProtKB/TrEMBL
KEGG Report pps:100993607 UniProtKB/TrEMBL
NCBI Gene EEF2 ENTREZGENE
PANTHER ELONGATION FACTOR 2 UniProtKB/TrEMBL
  TRANSLATION ELONGATION FACTOR-RELATED UniProtKB/TrEMBL
Pfam EFG_C UniProtKB/TrEMBL
  EFG_III UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
  GTP_EFTU UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
PRINTS ELONGATNFCT UniProtKB/TrEMBL
PROSITE G_TR_1 UniProtKB/TrEMBL
  G_TR_2 UniProtKB/TrEMBL
SMART EFG_C UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
Superfamily-SCOP SSF50447 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
  SSF54980 UniProtKB/TrEMBL
UniProt A0A2R9CBT4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CBZ9_PANPA UniProtKB/TrEMBL
  A0A2R9CEE9 ENTREZGENE, UniProtKB/TrEMBL