LOC100978961 (lymphotactin) - Rat Genome Database

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Gene: LOC100978961 (lymphotactin) Pan paniscus
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Symbol: LOC100978961 (Ensembl: XCL2)
Name: lymphotactin (Ensembl:X-C motif chemokine ligand 2)
RGD ID: 11814271
Description: ENCODES a protein that exhibits chemokine receptor binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell-cell signaling (ortholog); cellular response to interleukin-4 (ortholog); ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); gastrointestinal stromal tumor (ortholog); parathyroid carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chemokine (C motif) ligand 1; X-C motif chemokine ligand 1; XCL1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,183,655 - 81,414,929 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1180,852,442 - 81,083,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,837,578 - 144,068,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,563,331 - 147,790,587 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,785,654 - 147,790,587 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell-cell signaling  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chemotaxis  (IEA,ISO)
eosinophil chemotaxis  (IEA)
establishment of localization in cell  (ISO)
immune response  (IEA)
mature natural killer cell chemotaxis  (ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of T-helper 1 cell activation  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of B cell chemotaxis  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of granzyme A production  (ISO)
positive regulation of granzyme B production  (ISO)
positive regulation of immunoglobulin production in mucosal tissue  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of leukocyte chemotaxis  (ISO)
positive regulation of natural killer cell chemotaxis  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of T cell cytokine production  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T-helper 1 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of thymocyte migration  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
regulation of inflammatory response  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to virus  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100978961
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,183,655 - 81,414,929 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1180,852,442 - 81,083,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,837,578 - 144,068,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,563,331 - 147,790,587 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,785,654 - 147,790,587 (+)Ensemblpanpan1.1panPan2
XCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,576,605 - 168,582,069 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,576,605 - 168,582,069 (+)EnsemblGRCh38hg38GRCh38
GRCh371168,545,843 - 168,551,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,812,480 - 166,817,939 (+)NCBINCBI36Build 36hg18NCBI36
Build 341165,277,513 - 165,282,973NCBI
Celera1141,655,651 - 141,661,108 (+)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,791,807 - 139,797,411 (+)NCBIHuRef
CHM1_11169,967,701 - 169,973,305 (+)NCBICHM1_1
T2T-CHM13v2.01167,929,278 - 167,937,161 (+)NCBIT2T-CHM13v2.0
Xcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,759,216 - 164,763,094 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1164,759,213 - 164,763,096 (-)EnsemblGRCm39 Ensembl
GRCm381164,931,644 - 164,935,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,931,644 - 164,935,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv371166,861,779 - 166,865,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361166,768,323 - 166,772,185 (-)NCBIMGSCv36mm8
Celera1167,368,241 - 167,372,103 (-)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map172.26NCBI
Xcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81379,781,784 - 79,785,440 (-)NCBIGRCr8
mRatBN7.21377,248,687 - 77,252,343 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,248,717 - 77,252,329 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,865,290 - 79,868,746 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,169,308 - 81,172,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,411,156 - 78,414,618 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,199,402 - 83,202,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,199,264 - 83,202,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,079,753 - 88,083,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41380,691,195 - 80,694,638 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11380,705,382 - 80,708,826 (-)NCBI
Celera1376,965,267 - 76,968,710 (-)NCBICelera
Cytogenetic Map13q23NCBI
Xcl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554628,594,416 - 8,598,101 (-)NCBIChiLan1.0ChiLan1.0
LOC490356
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1729,986,433 - 29,991,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha729,518,512 - 29,708,129 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0729,804,708 - 29,995,081 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1729,637,969 - 29,827,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0729,673,524 - 29,863,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0729,911,837 - 30,102,031 (-)NCBIUU_Cfam_GSD_1.0
LOC101970885
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,978,802 - 99,991,355 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648117,825,714 - 17,828,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl482,432,204 - 82,436,180 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1482,432,845 - 82,436,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,116,396 - 90,119,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605562,128,985 - 62,134,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSPPAT00000063720   ⟹   ENSPPAP00000040801
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1147,785,654 - 147,790,587 (+)Ensembl
RefSeq Acc Id: XM_034939944   ⟹   XP_034795835
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,414,929 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,083,586 (-)NCBI
Mhudiblu_PPA_v01143,837,578 - 144,068,261 (+)NCBI
RefSeq Acc Id: XM_034939953   ⟹   XP_034795844
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,414,927 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,083,582 (-)NCBI
Mhudiblu_PPA_v01143,861,536 - 144,068,261 (+)NCBI
RefSeq Acc Id: XM_034939974   ⟹   XP_034795865
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,344,269 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,013,093 (-)NCBI
Mhudiblu_PPA_v01143,907,653 - 144,068,261 (+)NCBI
RefSeq Acc Id: XM_034939985   ⟹   XP_034795876
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,344,269 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,013,093 (-)NCBI
Mhudiblu_PPA_v01143,907,652 - 144,068,261 (+)NCBI
RefSeq Acc Id: XM_055111888   ⟹   XP_054967863
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,414,929 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,083,586 (-)NCBI
RefSeq Acc Id: XM_055111905   ⟹   XP_054967880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,414,927 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,083,582 (-)NCBI
RefSeq Acc Id: XM_055111909   ⟹   XP_054967884
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,183,655 - 81,414,925 (-)NCBI
NHGRI_mPanPan1180,852,442 - 81,083,581 (-)NCBI
RefSeq Acc Id: XP_034795835   ⟸   XM_034939944
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034795844   ⟸   XM_034939953
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034795876   ⟸   XM_034939985
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CFQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795865   ⟸   XM_034939974
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CFQ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000040801   ⟸   ENSPPAT00000063720
RefSeq Acc Id: XP_054967863   ⟸   XM_055111888
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054967880   ⟸   XM_055111905
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054967884   ⟸   XM_055111909
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CFQ7 (UniProtKB/TrEMBL)
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063720.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Chemokine_XCL1/XCL2 UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
NCBI Gene LOC100978961 ENTREZGENE
PANTHER PTHR12015 UniProtKB/TrEMBL
  PTHR12015:SF101 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS LYMPHOTACTIN UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A2R9CFQ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 LOC100978961  lymphotactin  XCL1  X-C motif chemokine ligand 1  Symbol and/or name change 5135510 APPROVED
2020-07-01 XCL1  X-C motif chemokine ligand 1  LOC100978961  lymphotactin  Symbol and/or name change 5135510 APPROVED