AKR1B10 (aldo-keto reductase family 1 member B10)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: AKR1B10 (aldo-keto reductase family 1 member B10) Pan paniscus

Analyze

Symbol:

AKR1B10

Name:

aldo-keto reductase family 1 member B10

RGD ID:

11810662

Description:

ENCODES a protein that exhibits alditol:NADP+ 1-oxidoreductase activity (ortholog); NADP+ binding (ortholog); NADP-retinol dehydrogenase activity (ortholog); INVOLVED IN polyol metabolic process (ortholog); retinal metabolic process (ortholog); retinol metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Colorectal Neoplasms (ortholog); contact dermatitis (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	138,992,802 - 139,006,042 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	138,992,835 - 139,006,003 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	126,486,012 - 126,499,852 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Colorectal Neoplasms (ISO)

contact dermatitis (ISO)

disease of cellular proliferation (ISO)

Endometrial Neoplasms (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

melanoma (ISO)

Neoplasm Invasiveness (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular detoxification of aldehyde (IEA)

daunorubicin metabolic process (IEA)

doxorubicin metabolic process (IEA)

farnesol catabolic process (IEA)

polyol metabolic process (ISO)

retinal metabolic process (ISO)

retinoid metabolic process (IEA)

retinol metabolic process (IEA,ISO)

Cellular Component

cytosol (ISO)

extracellular region (IEA)

lysosome (IEA)

Molecular Function

alcohol dehydrogenase (NADP+) activity (IEA)

alditol:NADP+ 1-oxidoreductase activity (ISO)

geranylgeranyl reductase activity (IEA)

indanol dehydrogenase activity (IEA)

NADP+ binding (ISO)

NADP-retinol dehydrogenase activity (IEA,ISO)

NADPH binding (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

retinal binding (ISO)

retinal dehydrogenase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

retinol metabolic pathway (ISO)

References

Genomics

Comparative Map Data

AKR1B10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	138,992,802 - 139,006,042 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	138,992,835 - 139,006,003 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	126,486,012 - 126,499,852 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

AKR1B10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	134,527,567 - 134,541,412 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	134,527,567 - 134,541,412 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	134,212,319 - 134,226,164 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	133,862,939 - 133,876,700 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	133,669,653 - 133,683,413	NCBI
Celera	7	128,949,765 - 128,963,585 (+)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI
HuRef	7	128,514,188 - 128,528,007 (+)	NCBI		HuRef
CHM1_1	7	134,146,625 - 134,160,442 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	135,835,650 - 135,849,492 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	133,556,663 - 133,570,483 (+)	NCBI

Akr1b10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	34,361,182 - 34,373,884 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	34,361,153 - 34,373,885 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	34,384,247 - 34,396,949 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	34,384,218 - 34,396,950 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	34,334,247 - 34,346,949 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	34,314,405 - 34,327,107 (+)	NCBI		MGSCv36	mm8
Celera	6	34,380,662 - 34,393,359 (+)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI

Akr1b10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	63,038,459 - 63,060,336 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	63,040,169 - 63,053,852 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	67,989,273 - 68,004,664 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	63,904,967 - 63,920,356 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	62,307,393 - 62,322,778 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	61,813,265 - 61,830,371 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	61,771,970 - 61,828,657 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	61,550,785 - 61,568,072 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	61,755,871 - 61,771,264 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	62,032,000 - 62,047,393 (+)	NCBI
Celera	4	58,091,866 - 58,107,253 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014345810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000040760 ⟹ ENSPPAP00000018035

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	138,992,835 - 139,006,003 (+)	Ensembl

RefSeq Acc Id:

XM_014345810 ⟹ XP_014201296

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	7	138,992,802 - 139,006,042 (+)	NCBI
Mhudiblu_PPA_v0	7	126,486,012 - 126,499,852 (+)	NCBI

Sequence:

show sequence

ACCTGCTCACTCAGAATCATTTCTGCACCAACCATGGCCACGTTTGTGGAGCTCAGTACCAAAG
CCAAGATGCCCATTGTGGGCCTGGGCACTTGGAAGTCTCCTCTCGGCAAAGTGAAAGAAGCAGT
GAAGGTGGCCATTGATGCAGGATATCGGCACATTGACTGTGCCTATGTCTATCAGAATGAACAT
GAAGTCGGGGAAGCCATCCAAGAGAAGATCCAAGAGAAGGCTGTGAAGCGGGAGGACCTGTTCA
TCGTCAGCAAGTTGTGGCCCACTTTCTTTGAGAGACCCCTTGTGAGGAAAGCCTTTGAGAAGAC
CCTCAAGGACCTGAAGCTGAGCTATCTGGACGTCTATCTTATTCACTGGCCACAGGGATTCAAG
TCTGGGGATGACCTTTTCCCCAAAGATGATAAAGGTAATGCCATCGGTGGAAAAGCAACGTTCT
TGGACGCCTGGGAGGCCATGGAGGAGCTGGTGGACGAGGGGCTGGTGAAAGCCCTTGGGGTCTC
CAATTTCAGCCACTTCCAGATTGAGAAGCTCTTGAACAAACCTGGACTGAAATATAAACCAGTG
ACTAACCAGGTTGAGTGTCACCCATACCTCACACAGGAGAAACTGATCCAGTACTGCCACTCCA
AGGGCATCACTGTTACAGCCTACAGCCCCCTGGGCTCTCCGGATAGACCTTGGGCCAAGCCAGA
AGACCCTTCCCTGCTGGAGGATCCCAAGATTAAGGAGATTGCTGCAAAGCACNAAAAAACCGCA
GCCCAGGTTCTGATCCGTTTCCATATCCAGAGGAATGTGATTGTCATCCCCAAGTCTGTGACAC
CAGCACGCATTGTTGAGAACATTCAGGTCTTTGACTTTAAATTGAGTGACGAGGAGATGGCAAC
CATACTCAGCTTCAACAGAAACTGGAGGGCCTGTAACGTGTTGCAATCCTCTCATTTGGAAGAC
TATCCCTTCGATGCAGAATATTGAGGTTGAATCTCCTGGTGAGATTACACAGGGGATTCTCTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_014201296	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_014201296 ⟸ XM_014345810

- Sequence:

show sequence

MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQ
EKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDK
GNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLT
QEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHXKTAAQVLIRFHIQR
NVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFDAEY

hide sequence

RefSeq Acc Id:

ENSPPAP00000018035 ⟸ ENSPPAT00000040760

Protein Domains

NADP-dependent oxidoreductase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000032122	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000018035.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040760.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/TrEMBL
InterPro	AKR	UniProtKB/TrEMBL
	Aldo/ket_reductase_CS	UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/TrEMBL
NCBI Gene	AKR1B10	ENTREZGENE
PANTHER	ALDO/KETO REDUCTASE	UniProtKB/TrEMBL
	ALDO_KET_RED DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/TrEMBL
PIRSF	AKR	UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_2	UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/TrEMBL
UniProt	A0A2R9AQK3_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations