HOXB2 (homeobox B2) - Rat Genome Database

Name: HOXB2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: HOXB2 (homeobox B2) Pan paniscus

Analyze

Symbol:

HOXB2

Name:

homeobox B2

RGD ID:

11805748

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); dorsal/ventral pattern formation (ortholog); embryonic skeletal system morphogenesis (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein Hox-B2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HOXB2 (homeobox B2)	NCBI	Ortholog
Mus musculus (house mouse):	Hoxb2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Hoxb2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hoxb2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HOXB2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hoxb2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HOXB2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HOXB2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hoxb2 (homeobox B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	16,556,795 - 16,560,014 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	18,523,142 - 18,525,594 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	8,991,652 - 8,994,092 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	9,176,313 - 9,178,713 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	9,176,313 - 9,178,713 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IEA,ISO)

dorsal/ventral pattern formation (IEA,ISO)

embryonic skeletal system morphogenesis (IEA,ISO)

facial nerve structural organization (IEA,ISO)

morphogenesis of an epithelial sheet (IEA,ISO)

neural nucleus development (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

rhombomere 3 development (IEA,ISO)

rhombomere 4 development (IEA,ISO)

skeletal system morphogenesis (IEA,ISO)

Cellular Component

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HOXB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	16,556,795 - 16,560,014 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	18,523,142 - 18,525,594 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	8,991,652 - 8,994,092 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	9,176,313 - 9,178,713 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	9,176,313 - 9,178,713 (+)	Ensembl	panpan1.1		panPan2

HOXB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	48,542,655 - 48,545,109 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	48,540,894 - 48,545,109 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	46,620,017 - 46,622,471 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	43,975,016 - 43,977,392 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	43,975,019 - 43,977,391	NCBI
Celera	17	43,074,158 - 43,076,535 (-)	NCBI		Celera
Cytogenetic Map	17	q21.32	NCBI
HuRef	17	41,989,338 - 41,991,636 (-)	NCBI		HuRef
CHM1_1	17	46,685,958 - 46,688,334 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	49,406,234 - 49,408,688 (-)	NCBI		T2T-CHM13v2.0

Hoxb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	96,242,458 - 96,244,846 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	96,241,351 - 96,244,838 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	96,351,632 - 96,354,020 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	96,350,525 - 96,354,012 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	96,212,946 - 96,215,330 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	96,168,891 - 96,170,106 (+)	NCBI		MGSCv36	mm8
Celera	11	106,002,498 - 106,004,882 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	59.85	NCBI

Hoxb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	81,814,340 - 81,816,731 (+)	NCBI		GRCr8
mRatBN7.2	10	81,317,828 - 81,320,220 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	81,318,026 - 81,320,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	86,266,813 - 86,269,204 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	85,764,865 - 85,767,256 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	81,157,314 - 81,159,705 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	84,200,859 - 84,203,065 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	84,200,880 - 84,202,688 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	84,003,524 - 84,005,718 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	85,085,425 - 85,087,617 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	85,099,760 - 85,101,981 (+)	NCBI
Celera	10	80,084,076 - 80,086,261 (+)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Hoxb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	12,694,868 - 12,697,846 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	12,693,764 - 12,697,825 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOXB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	24,803,996 - 24,810,109 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	24,804,426 - 24,806,614 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	24,268,266 - 24,272,531 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	25,598,684 - 25,602,966 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	25,598,682 - 25,601,013 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	24,366,921 - 24,371,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	24,627,553 - 24,631,821 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	24,755,685 - 24,759,948 (-)	NCBI		UU_Cfam_GSD_1.0

Hoxb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	24,231,250 - 24,233,965 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	12,841,695 - 12,843,494 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	12,841,286 - 12,843,782 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOXB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	24,797,225 - 24,799,303 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	24,796,786 - 24,800,499 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	24,754,243 - 24,757,824 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HOXB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	68,955,651 - 68,958,422 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	68,956,061 - 68,957,903 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	40,010,169 - 40,012,813 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hoxb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	5,042,991 - 5,046,030 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	5,043,110 - 5,045,414 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003827499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000030994 ⟹ ENSPPAP00000008358

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	9,176,313 - 9,178,713 (+)	Ensembl

RefSeq Acc Id:

XM_003827499 ⟹ XP_003827547

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	16,556,795 - 16,560,014 (+)	NCBI
NHGRI_mPanPan1	17	18,523,142 - 18,525,594 (+)	NCBI
Mhudiblu_PPA_v0	17	8,991,652 - 8,994,092 (+)	NCBI
PanPan1.1	17	9,176,313 - 9,178,713 (+)	NCBI

Sequence:

show sequence

GCCCAAAATTAAAAAAAAGAGAGACCGAAATCTCCCCCTCCCAAAATCGCTCCATTACATAAAT
CTGGGGGGGGCAGAGGGGGGGTCCCGTTCCGATCCTCCCTCCTGACGCCCCCCCCAGCAGCCCC
CTCCCCCACCATTGAAAGCCATGAATTTTGAATTTGAGAGGGAGATTGGGTTTATAAACAGCCA
GCCGTCGCTCGCCGAGTGTCTGACTTCCTTCCCCGCTGTCTTGGAGACATTTCAAACTTCATCA
ATCAAGGAGTCGACATTAATTCCTCCTCCTCCTCCTTTCGAGCAAACCTTCCCCAGCCTCCAGC
CCGGCGCCTCCACCCTTCAGAGACCCAGGAGCCAAAAGCGAGCCGAAGATGGGCCTGCTCTGCC
GCCGCCACCGCCGCCGCCACTCCCCGCTGCCCCCCCGGCCCCCGAGTTCCCTTGGATGAAAGAG
AAGAAATCCGCCAAGAAACCCAGCCAATCCGCCACGTCTCCTTCTCCGGCCGCCTCCGCCGTTC
CGGCCTCCGGGGTCGGATCGCCTGCAGATGGCCTGGGACTGCCGGAGGCTGGTGGCGGCGGGGC
GCGCAGGCTGCGCACGGCTTACACCAACACGCAGCTGCTGGAACTGGAGAAGGAATTCCACTTT
AATAAGTACCTGTGCCGGCCACGCCGCGTCGAGATCGCGGCCTTGCTGGACCTCACCGAAAGGC
AGGTCAAAGTCTGGTTTCAGAACCGGCGCATGAAGCACAAGCGGCAGACGCAGCACCGAGAGCC
GCCGGATGGGGAGCCTGCCTGCCCGGGAGCCCTGGAGGACATCTGCGACCCTGCCGAGGAGCCC
GCGGCCAGCCCGGGCGGCCCCTCCGCCTCGCGGGCGGCGTGGGAAGCCTGCTGTCACCCGCCGG
AGATGGTGCCGGGGGCCTTAAGCGCGGACCCCCGGCCTTTAGCCGTTCGCTTAGAGGGCGCAGG
CGCGTCGAGCCCCGACTGCGCTCTGCGCGGGGCCGGCGGGCTGGAGCCCGGGCCATTGCCAGAA
GACGTCTTCTCGGGGCGCCAGGATTCACCTTTCCTTCCCGACCTCAACTTCTTCGCGGCCGACT
CCTGTCTCCAGCTATCCGGAGGCCTCTCCCCTAGCCTACAGGGTTCTCTCGACAGCCCGGTCCC
TTTTTCCGAGGAAGAGCTGGATTTTTTCACCAGTACGCTCTGTGCCATCGACCTGCAGTTTCCC
TAACCCGTTTCCTCCTCCCGGTCCTTTCGACCCCCGCGCTCCTTGGCCGTCTACTGGAAAAATC
GAGCCTCTCCCACCCTCAGTCGCATAGACTTATGTGTTTTGCTAAAATTCAGGTATTACTGAAT
TAGCGTTTAATCCACTCCCTTTCTTCTTCTAAAATATTGGGCACTCGGTCATCTTTTAAAATTC
ACACAGAAAAATTCCGTTTGGTAGACTCCTTCCAATGAAATCTCAGGAATAATTAAACTCTAGG
GGGACTTTCTTAAAAATAACTAGAGGGACCTATTTTCCTCTTTTTTATGTTTTAGACTGTAGAT
TATTTATTAAAATTCTTTAATAATAGGAAAAGGGGAAAGTATTTATTGTACATTATTTTCATAG
ATTAAATAAATGTCTTTATAATACCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003827547	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008358.1

RefSeq Acc Id:

XP_003827547 ⟸ XM_003827499

- UniProtKB:

A0A2R8ZZG6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGASTLQ
RPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGS
PADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQ
NRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEMVPGAL
SADPRPLAVRLEGAGASSPDCALRGAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSG
GLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP

hide sequence

RefSeq Acc Id:

ENSPPAP00000008358 ⟸ ENSPPAT00000030994

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027417	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000030994.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_Antennapedia_CS	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
KEGG Report	pps:100992143	UniProtKB/TrEMBL
NCBI Gene	HOXB2	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN HOX-B2	UniProtKB/TrEMBL
	PROTEIN ZERKNUELLT 1-RELATED	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	ANTENNAPEDIA	UniProtKB/TrEMBL
	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A2R8ZZG6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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