METTL4 (methyltransferase 4, N6-adenosine) - Rat Genome Database

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Gene: METTL4 (methyltransferase 4, N6-adenosine) Pan paniscus
Analyze
Symbol: METTL4
Name: methyltransferase 4, N6-adenosine
RGD ID: 11792356
Description: ENCODES a protein that exhibits catalytic activity, acting on a nucleic acid (inferred); methyltransferase activity (inferred); nucleic acid binding (inferred); INVOLVED IN negative regulation of gene expression, epigenetic (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytosol (inferred); mitochondrial matrix (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyltransferase like 4; methyltransferase-like protein 4; N(6)-adenine-specific methyltransferase METTL4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21735,874,434 - 35,908,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11821,567,026 - 21,600,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01811,711,502 - 11,745,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11814,018,279 - 14,051,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1814,018,279 - 14,051,974 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
METTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21735,874,434 - 35,908,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11821,567,026 - 21,600,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01811,711,502 - 11,745,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11814,018,279 - 14,051,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1814,018,279 - 14,051,974 (+)Ensemblpanpan1.1panPan2
METTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38182,537,530 - 2,571,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl182,537,525 - 2,571,509 (-)EnsemblGRCh38hg38GRCh38
GRCh37182,537,529 - 2,571,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36182,527,524 - 2,561,489 (-)NCBINCBI36Build 36hg18NCBI36
Build 34182,527,529 - 2,561,470NCBI
Celera182,412,830 - 2,446,793 (-)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef182,499,255 - 2,532,978 (-)NCBIHuRef
CHM1_1182,536,901 - 2,570,862 (-)NCBICHM1_1
T2T-CHM13v2.0182,693,282 - 2,727,252 (-)NCBIT2T-CHM13v2.0
Mettl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391795,030,018 - 95,057,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1795,030,018 - 95,057,447 (-)EnsemblGRCm39 Ensembl
GRCm381794,722,590 - 94,750,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1794,722,590 - 94,750,019 (-)EnsemblGRCm38mm10GRCm38
MGSCv371795,126,420 - 95,149,232 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361795,031,189 - 95,054,001 (-)NCBIMGSCv36mm8
Celera1799,126,838 - 99,149,657 (-)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1761.17NCBI
Mettl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,887,740 - 118,967,433 (+)NCBIGRCr8
mRatBN7.29111,440,976 - 111,523,871 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9111,441,027 - 111,464,749 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9119,844,679 - 119,866,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,973,930 - 124,995,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09123,310,491 - 123,332,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,871,519 - 119,953,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,873,170 - 119,897,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09119,324,922 - 119,373,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,736,288 - 110,766,258 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,945,767 - 110,975,115 (+)NCBI
Celera9108,569,553 - 108,589,384 (+)NCBICelera
Cytogenetic Map9q38NCBI
Mettl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554027,732,627 - 7,763,038 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554027,733,220 - 7,762,756 (+)NCBIChiLan1.0ChiLan1.0
METTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,229,717 - 69,268,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl769,191,223 - 69,267,683 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha768,665,874 - 68,723,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0769,272,450 - 69,330,069 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,291,648 - 69,329,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1768,955,089 - 69,012,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0768,975,650 - 69,032,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,272,402 - 69,330,056 (-)NCBIUU_Cfam_GSD_1.0
Mettl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494465,601,744 - 65,630,845 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366721,910,851 - 1,941,520 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366721,911,109 - 1,940,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6104,055,814 - 104,078,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16104,055,813 - 104,384,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
METTL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11861,767,806 - 61,834,994 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1861,799,324 - 61,834,973 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605036,653,215 - 36,694,906 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477012,905,100 - 12,938,189 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477012,905,138 - 12,937,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037288   ⟹   ENSPPAP00000014601
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1814,018,279 - 14,051,974 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037292   ⟹   ENSPPAP00000014605
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1814,022,557 - 14,050,432 (+)Ensembl
RefSeq Acc Id: XM_003817885   ⟹   XP_003817933
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21735,874,434 - 35,908,314 (+)NCBI
NHGRI_mPanPan11821,567,026 - 21,600,906 (+)NCBI
Mhudiblu_PPA_v01811,711,502 - 11,745,222 (+)NCBI
PanPan1.11814,018,279 - 14,051,974 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034943533   ⟹   XP_034799424
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21735,874,594 - 35,908,314 (+)NCBI
NHGRI_mPanPan11821,567,407 - 21,600,906 (+)NCBI
Mhudiblu_PPA_v01811,711,502 - 11,745,222 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003817933 (Get FASTA)   NCBI Sequence Viewer  
  XP_034799424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014601.1
  ENSPPAP00000014605.1
Reference Protein Sequences
RefSeq Acc Id: XP_003817933   ⟸   XM_003817885
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ACH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034799424   ⟸   XM_034943533
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000014605   ⟸   ENSPPAT00000037292
RefSeq Acc Id: ENSPPAP00000014601   ⟸   ENSPPAT00000037288


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037288.1 UniProtKB/TrEMBL
  ENSPPAT00000037292.1 UniProtKB/TrEMBL
InterPro DNA_methylase_N6_adenine_CS UniProtKB/TrEMBL
  MT-A70-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report pps:100975333 UniProtKB/TrEMBL
NCBI Gene METTL4 ENTREZGENE
PANTHER N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4 UniProtKB/TrEMBL
  N6-ADENOSINE-METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/TrEMBL
PROSITE MT_A70 UniProtKB/TrEMBL
  N6_MTASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A2R9ABG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ACH1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-25 METTL4  methyltransferase 4, N6-adenosine  METTL4  methyltransferase like 4  Symbol and/or name change 5135510 APPROVED