LOC100986336 (twinfilin-2) - Rat Genome Database

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Gene: LOC100986336 (twinfilin-2) Pan paniscus
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Symbol: LOC100986336
Name: twinfilin-2
RGD ID: 11790303
Description: ENCODES a protein that exhibits actin binding (inferred); actin monomer binding (inferred); ATP binding (inferred); INVOLVED IN activation of innate immune response (inferred); cellular response to chloroquine (inferred); cellular response to growth factor stimulus (inferred); FOUND IN apical plasma membrane (inferred); basolateral plasma membrane (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TLR9; toll-like receptor 9
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1353,392,669 - 53,410,743 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,400,191 - 53,410,743 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0352,163,388 - 52,181,473 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA)
cellular response to chloroquine  (IEA)
cellular response to growth factor stimulus  (IEA)
cellular response to retinoic acid  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to virus  (IEA)
I-kappaB kinase/NF-kappaB signaling  (IEA)
I-kappaB phosphorylation  (IEA)
immune response  (IEA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
maintenance of gastrointestinal epithelium  (IEA)
MyD88-dependent toll-like receptor signaling pathway  (IEA)
negative regulation of actin filament polymerization  (IEA)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of interleukin-8 production  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA)
negative regulation of toll-like receptor signaling pathway  (IEA)
positive regulation of axon extension  (IEA)
positive regulation of B cell activation  (IEA)
positive regulation of B cell proliferation  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of immunoglobulin production  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-18 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JUN kinase activity  (IEA)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of neuron projection development  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA)
positive regulation of toll-like receptor 9 signaling pathway  (IEA)
positive regulation of toll-like receptor signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
regulation of actin cytoskeleton organization  (IEA)
regulation of B cell activation  (IEA)
regulation of B cell differentiation  (IEA)
regulation of cytokine production  (IEA)
regulation of dendritic cell cytokine production  (IEA)
regulation of immune response  (IEA)
regulation of inflammatory response  (IEA)
regulation of protein phosphorylation  (IEA)
regulation of toll-like receptor 9 signaling pathway  (IEA)
regulation of transcription, DNA-templated  (IEA)
response to molecule of bacterial origin  (IEA)
response to virus  (IEA)
signal transduction  (IEA)
toll-like receptor 9 signaling pathway  (IEA)

References
Additional References at PubMed
PMID:18810425  


Genomics


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000042614   ⟹   ENSPPAP00000019837
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,400,191 - 53,410,743 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000042621   ⟹   ENSPPAP00000019844
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,400,778 - 53,410,598 (-)Ensembl
RefSeq Acc Id: XM_003818764   ⟹   XP_003818812
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1353,392,669 - 53,410,743 (-)NCBI
Mhudiblu_PPA_v0352,163,389 - 52,181,473 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972142   ⟹   XP_008970390
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1353,392,669 - 53,397,756 (-)NCBI
Mhudiblu_PPA_v0352,163,388 - 52,171,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972143   ⟹   XP_008970391
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1353,400,191 - 53,410,743 (-)NCBI
Mhudiblu_PPA_v0352,170,913 - 52,181,462 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818812 (Get FASTA)   NCBI Sequence Viewer  
  XP_008970390 (Get FASTA)   NCBI Sequence Viewer  
  XP_008970391 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAG55072 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003818812   ⟸   XM_003818764
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008970390   ⟸   XM_008972142
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008970391   ⟸   XM_008972143
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000019844   ⟸   ENSPPAT00000042621
RefSeq Acc Id: ENSPPAP00000019837   ⟸   ENSPPAT00000042614
Protein Domains
ADF-H   TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000018063 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAG00000033131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000004273 UniProtKB/TrEMBL
  ENSPPAP00000004282 UniProtKB/TrEMBL
  ENSPPAP00000019837 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000019844 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000019771 UniProtKB/TrEMBL
  ENSPPAT00000019826 UniProtKB/TrEMBL
  ENSPPAT00000042614 UniProtKB/TrEMBL
  ENSPPAT00000042621 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro ADF-H UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_12 UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  TLR9 UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
  Twinfilin UniProtKB/TrEMBL
NCBI Gene LOC100986336 ENTREZGENE
PANTHER PTHR13759 UniProtKB/TrEMBL
  PTHR47410:SF3 UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/TrEMBL
  LRR_12 UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PROSITE ADF_H UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART ADF UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A2R8ZK90_PANPA UniProtKB/TrEMBL
  A0A2R9AR52_PANPA UniProtKB/TrEMBL
  A0A2R9AXS0_PANPA UniProtKB/TrEMBL
  B3Y663_PANPA UniProtKB/TrEMBL