THRA (thyroid hormone receptor alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: THRA (thyroid hormone receptor alpha) Pan paniscus
Analyze
Symbol: THRA
Name: thyroid hormone receptor alpha
RGD ID: 11787328
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); general transcription initiation factor binding (ortholog); INVOLVED IN adrenal gland development (ortholog); animal organ morphogenesis (ortholog); brain development (ortholog); ASSOCIATED WITH breast cancer (ortholog); congenital nongoitrous hypothyroidism 6 (ortholog); Diaphragmatic Hernia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: thyroid hormone receptor, alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,420,186 - 17,448,502 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01717,196,459 - 17,226,263 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
animal organ morphogenesis  (IEA,ISO)
brain development  (ISO)
cartilage condensation  (IEA,ISO)
cytoplasmic sequestering of transcription factor  (ISO)
digestive tract development  (ISO)
embryonic organ development  (ISO)
erythrocyte differentiation  (IEA,ISO)
female courtship behavior  (IEA,ISO)
hormone-mediated signaling pathway  (ISO)
intracellular receptor signaling pathway  (IEA)
kidney development  (ISO)
learning or memory  (IEA,ISO)
liver development  (ISO)
lung development  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription, initiation  (ISO)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
negative regulation of transcription, DNA-templated  (IEA,ISO)
ossification  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of female receptivity  (IEA,ISO)
positive regulation of myotube differentiation  (ISO)
positive regulation of thyroid hormone mediated signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of heart contraction  (IEA,ISO)
regulation of lipid catabolic process  (IEA,ISO)
regulation of myeloid cell apoptotic process  (IEA,ISO)
regulation of thyroid hormone mediated signaling pathway  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
response to cold  (IEA,ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
thyroid gland development  (IEA,ISO)
transcription by RNA polymerase II  (ISO)
type I pneumocyte differentiation  (IEA,ISO)

Cellular Component

References

Genomics

Comparative Map Data
THRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,420,186 - 17,448,502 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01717,196,459 - 17,226,263 (-)NCBIMhudiblu_PPA_v0panPan3
THRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1740,058,290 - 40,093,867 (+)EnsemblGRCh38hg38GRCh38
GRCh381740,062,193 - 40,093,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,218,446 - 38,250,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,472,589 - 35,503,646 (+)NCBINCBI36hg18NCBI36
Build 341735,472,588 - 35,499,815NCBI
Celera1734,878,512 - 34,910,230 (+)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1734,012,227 - 34,043,856 (+)NCBIHuRef
CHM1_11738,454,163 - 38,485,823 (+)NCBICHM1_1
Thra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,631,539 - 98,659,832 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,631,464 - 98,659,832 (+)Ensembl
GRCm381198,740,776 - 98,769,006 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,740,638 - 98,769,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,603,187 - 98,626,425 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,557,963 - 98,581,201 (+)NCBImm8
Celera11108,407,991 - 108,419,811 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.58NCBI
Thra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,701,885 - 83,729,408 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1083,700,755 - 83,729,936 (+)Ensembl
Rnor_6.01086,657,285 - 86,684,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,657,285 - 86,684,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,453,436 - 86,480,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,514,443 - 87,542,306 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,540,629 - 87,556,674 (+)NCBI
Celera1082,449,971 - 82,477,615 (+)NCBICelera
RH 3.4 Map10839.79RGD
Cytogenetic Map10q31NCBI
Thra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,731,746 - 14,744,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,731,746 - 14,743,545 (+)NCBIChiLan1.0ChiLan1.0
THRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,469,466 - 22,493,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,468,594 - 22,493,445 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,941,798 - 21,965,472 (-)NCBI
ROS_Cfam_1.0923,262,655 - 23,286,090 (-)NCBI
ROS_Cfam_1.0 Ensembl923,261,287 - 23,285,973 (-)Ensembl
UMICH_Zoey_3.1922,036,085 - 22,059,532 (-)NCBI
UNSW_CanFamBas_1.0922,295,080 - 22,318,722 (-)NCBI
UU_Cfam_GSD_1.0922,419,817 - 22,443,287 (-)NCBI
Thra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,869,085 - 21,886,778 (-)NCBI
SpeTri2.0NW_00493649015,188,341 - 15,206,032 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,270,062 - 22,296,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,270,506 - 22,296,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,488,984 - 22,497,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,087,071 - 66,118,137 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607736,990,432 - 37,021,543 (-)NCBIVero_WHO_p1.0
Thra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,109,663 - 3,132,494 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034941932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_034941932   ⟹   XP_034797823
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01717,196,459 - 17,226,263 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034797823 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034797823   ⟸   XM_034941932
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037731 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000029523 UniProtKB/TrEMBL
  ENSPPAP00000029537 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052372 UniProtKB/TrEMBL
  ENSPPAT00000052386 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report pps:100971326 UniProtKB/TrEMBL
NCBI Gene THRA ENTREZGENE
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/TrEMBL
UniProt A0A2R9BJJ5_PANPA UniProtKB/TrEMBL
  A0A2R9BM97_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-06 THRA  thyroid hormone receptor alpha    thyroid hormone receptor, alpha  Symbol and/or name change 5135510 APPROVED