EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1) - Rat Genome Database

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Gene: EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1) Pan paniscus
Analyze
Symbol: EDEM1
Name: ER degradation enhancing alpha-mannosidase like protein 1
RGD ID: 11786163
Description: ENCODES a protein that exhibits alpha-mannosidase activity (ortholog); mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (ortholog); INVOLVED IN ERAD pathway (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN aggresome (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ER degradation-enhancing alpha-mannosidase-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v225,192,405 - 5,224,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan135,197,163 - 5,229,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v035,133,927 - 5,162,485 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,234,108 - 5,266,057 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,234,123 - 5,262,003 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EDEM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v225,192,405 - 5,224,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan135,197,163 - 5,229,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v035,133,927 - 5,162,485 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.135,234,108 - 5,266,057 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,234,123 - 5,262,003 (+)Ensemblpanpan1.1panPan2
EDEM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3835,187,707 - 5,219,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl35,187,646 - 5,219,958 (+)EnsemblGRCh38hg38GRCh38
GRCh3735,229,392 - 5,261,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3635,204,433 - 5,236,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 3435,204,432 - 5,236,642NCBI
Celera35,167,241 - 5,199,525 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef35,161,963 - 5,194,537 (+)NCBIHuRef
CHM1_135,179,737 - 5,212,027 (+)NCBICHM1_1
T2T-CHM13v2.035,181,638 - 5,213,889 (+)NCBIT2T-CHM13v2.0
Edem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,800,984 - 108,836,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,805,602 - 108,836,317 (+)EnsemblGRCm39 Ensembl
GRCm386108,824,045 - 108,859,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,828,641 - 108,859,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,778,635 - 108,809,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,794,429 - 108,825,128 (+)NCBIMGSCv36mm8
Celera6110,630,730 - 110,662,933 (+)NCBICelera
Cytogenetic Map6E2NCBI
cM Map649.87NCBI
Edem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84143,350,989 - 143,385,693 (+)NCBIGRCr8
mRatBN7.24141,797,631 - 141,829,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,797,701 - 141,829,717 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4147,219,703 - 147,251,737 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04143,000,435 - 143,032,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,644,436 - 141,676,471 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,886,644 - 140,918,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,886,545 - 140,915,779 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04217,499,472 - 217,532,312 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,349,966 - 144,379,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4130,450,129 - 130,482,057 (+)NCBICelera
Cytogenetic Map4q41NCBI
Edem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,196,557 - 8,225,561 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,196,631 - 8,225,561 (-)NCBIChiLan1.0ChiLan1.0
EDEM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,444,013 - 12,473,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,452,730 - 12,472,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,418,401 - 12,446,815 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02012,487,485 - 12,515,859 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,487,377 - 12,515,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,193,009 - 12,221,286 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,534,428 - 12,562,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,520,467 - 12,548,815 (-)NCBIUU_Cfam_GSD_1.0
Edem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,531,211 - 11,558,394 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365774,486,885 - 4,513,555 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365774,486,617 - 4,516,379 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDEM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,703,621 - 61,732,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,703,601 - 61,732,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21368,054,514 - 68,138,465 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDEM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,253,861 - 41,286,185 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,253,989 - 41,282,140 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,336,058 - 125,368,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,846,553 - 15,878,803 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477315,846,347 - 15,878,312 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033146   ⟹   ENSPPAP00000010495
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl35,234,123 - 5,262,003 (+)Ensembl
RefSeq Acc Id: XM_014344136   ⟹   XP_014199622
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v225,192,515 - 5,224,784 (+)NCBI
NHGRI_mPanPan135,197,273 - 5,229,548 (+)NCBI
Mhudiblu_PPA_v035,134,040 - 5,162,485 (+)NCBI
PanPan1.135,234,108 - 5,257,731 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034955685   ⟹   XP_034811576
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v225,192,405 - 5,224,784 (+)NCBI
NHGRI_mPanPan135,197,163 - 5,229,547 (+)NCBI
Mhudiblu_PPA_v035,133,927 - 5,162,485 (+)NCBI
Protein Sequences
Protein RefSeqs XP_014199622 (Get FASTA)   NCBI Sequence Viewer  
  XP_034811576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010495.1
Reference Protein Sequences
RefSeq Acc Id: XP_014199622   ⟸   XM_014344136
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034811576   ⟸   XM_034955685
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A5D2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000010495   ⟸   ENSPPAT00000033146


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033146.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  EDEM1/2/3 UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
NCBI Gene EDEM1 ENTREZGENE
PANTHER ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR45679 UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP SSF48225 UniProtKB/TrEMBL
UniProt A0A2R9A5D2 ENTREZGENE, UniProtKB/TrEMBL