KLHL8 (kelch like family member 8) - Rat Genome Database

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Gene: KLHL8 (kelch like family member 8) Pan paniscus
Analyze
Symbol: KLHL8
Name: kelch like family member 8
RGD ID: 11781010
Description: INVOLVED IN protein ubiquitination (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 8; kelch-like protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,176,525 - 85,236,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,438,568 - 85,498,966 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,462,540 - 79,522,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,190,302 - 90,247,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,190,302 - 90,225,284 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,176,525 - 85,236,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,438,568 - 85,498,966 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,462,540 - 79,522,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,190,302 - 90,247,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,190,302 - 90,225,284 (-)Ensemblpanpan1.1panPan2
KLHL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,160,103 - 87,240,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,160,103 - 87,240,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37488,081,255 - 88,141,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,301,238 - 88,360,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 34488,439,392 - 88,498,853NCBI
Celera485,371,231 - 85,430,685 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef483,826,503 - 83,885,876 (-)NCBIHuRef
CHM1_1488,059,619 - 88,119,078 (-)NCBICHM1_1
T2T-CHM13v2.0490,489,165 - 90,569,763 (-)NCBIT2T-CHM13v2.0
Klhl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,009,916 - 104,059,137 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,009,839 - 104,059,125 (-)EnsemblGRCm39 Ensembl
GRCm385103,862,050 - 103,911,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5103,861,973 - 103,911,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv375104,291,069 - 104,340,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,102,352 - 104,151,531 (-)NCBIMGSCv36mm8
Celera5101,168,123 - 101,217,145 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.45NCBI
Klhl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,112,472 - 6,158,001 (+)NCBIGRCr8
mRatBN7.2145,807,795 - 5,853,325 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,807,907 - 5,853,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,775,288 - 5,820,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,075,516 - 7,121,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,773,843 - 5,819,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,169,517 - 7,215,025 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,169,519 - 7,215,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0147,159,371 - 7,204,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,958,124 - 7,003,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,978,904 - 7,003,611 (+)NCBI
Celera145,946,794 - 5,992,070 (+)NCBICelera
Cytogenetic Map14p22NCBI
Klhl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,652,992 - 2,710,616 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554742,652,992 - 2,710,616 (+)NCBIChiLan1.0ChiLan1.0
KLHL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,656,419 - 10,687,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,659,240 - 10,686,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3231,224,842 - 31,297,941 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03210,710,493 - 10,781,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,708,476 - 10,739,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13210,790,068 - 10,862,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,617,500 - 10,690,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,264,169 - 29,337,281 (+)NCBIUU_Cfam_GSD_1.0
Klhl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405285556,977 - 576,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049369204,186 - 25,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049369204,418 - 22,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,634,209 - 131,700,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,634,171 - 131,701,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,909,603 - 140,931,918 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,535,406 - 35,614,934 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,535,230 - 35,595,201 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603714,226,547 - 14,306,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,677,397 - 3,750,867 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248723,675,248 - 3,750,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000036465   ⟹   ENSPPAP00000013791
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl490,190,302 - 90,225,284 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000036474   ⟹   ENSPPAP00000013800
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl490,193,711 - 90,225,132 (-)Ensembl
RefSeq Acc Id: XM_034958893   ⟹   XP_034814784
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2385,176,525 - 85,236,648 (-)NCBI
NHGRI_mPanPan1485,438,568 - 85,498,963 (-)NCBI
Mhudiblu_PPA_v0479,462,540 - 79,522,547 (-)NCBI
RefSeq Acc Id: XM_034958894   ⟹   XP_034814785
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2385,176,525 - 85,236,643 (-)NCBI
NHGRI_mPanPan1485,438,568 - 85,498,963 (-)NCBI
Mhudiblu_PPA_v0479,462,540 - 79,522,485 (-)NCBI
RefSeq Acc Id: XM_055111601   ⟹   XP_054967576
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2385,176,525 - 85,236,388 (-)NCBI
NHGRI_mPanPan1485,438,568 - 85,498,550 (-)NCBI
RefSeq Acc Id: XM_055111602   ⟹   XP_054967577
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2385,176,525 - 85,221,361 (-)NCBI
NHGRI_mPanPan1485,438,568 - 85,482,520 (-)NCBI
RefSeq Acc Id: XM_063603569   ⟹   XP_063459639
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2385,176,525 - 85,236,623 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034814784   ⟸   XM_034958893
- UniProtKB: A0A2R9AA74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034814785   ⟸   XM_034958894
- UniProtKB: A0A2R9AA74 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000013800   ⟸   ENSPPAT00000036474
RefSeq Acc Id: ENSPPAP00000013791   ⟸   ENSPPAT00000036465
RefSeq Acc Id: XP_054967576   ⟸   XM_055111601
- UniProtKB: A0A2R9AA74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054967577   ⟸   XM_055111602
- UniProtKB: A0A2R9AA74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459639   ⟸   XM_063603569
- UniProtKB: A0A2R9AA74 (UniProtKB/TrEMBL)
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030051 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036465.1 UniProtKB/TrEMBL
  ENSPPAT00000036474.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL8 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN DIABLO UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF50965 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A2R9A953_PANPA UniProtKB/TrEMBL
  A0A2R9AA74 ENTREZGENE, UniProtKB/TrEMBL