MED16 (mediator complex subunit 16) - Rat Genome Database

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Gene: MED16 (mediator complex subunit 16) Pan paniscus
Analyze
Symbol: MED16
Name: mediator complex subunit 16
RGD ID: 11779683
Description: ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (inferred); transcription coactivator activity (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of transcription initiation by RNA polymerase II (inferred); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); endometriosis (ortholog); FOUND IN core mediator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mediator of RNA polymerase II transcription subunit 16
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,200,059 - 5,224,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,437,887 - 4,463,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019238,822 - 260,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119840,896 - 864,857 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19841,367 - 863,080 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MED16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,200,059 - 5,224,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,437,887 - 4,463,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019238,822 - 260,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119840,896 - 864,857 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19841,367 - 863,080 (-)Ensemblpanpan1.1panPan2
MED16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819867,963 - 893,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19867,630 - 893,218 (-)EnsemblGRCh38hg38GRCh38
GRCh3719867,963 - 893,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619818,962 - 844,218 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419818,961 - 844,218NCBI
Celera19793,449 - 825,585 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19636,814 - 665,338 (-)NCBIHuRef
CHM1_119867,504 - 891,842 (-)NCBICHM1_1
T2T-CHM13v2.019824,038 - 855,915 (-)NCBIT2T-CHM13v2.0
Med16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,730,543 - 79,744,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,730,542 - 79,744,757 (-)EnsemblGRCm39 Ensembl
GRCm381079,894,706 - 79,908,938 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,894,708 - 79,908,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,357,452 - 79,371,683 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,297,839 - 79,312,021 (-)NCBIMGSCv36mm8
Celera1080,909,517 - 80,923,748 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Med16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,449,273 - 10,461,797 (+)NCBIGRCr8
mRatBN7.279,798,641 - 9,811,172 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,680,662 - 12,693,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,555,979 - 14,568,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,417,166 - 12,429,673 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,619,739 - 12,632,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,542,713 - 12,632,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,789,458 - 12,801,962 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,311,063 - 11,323,562 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,312,038 - 11,323,250 (+)NCBI
Celera77,973,419 - 7,985,920 (+)NCBICelera
Cytogenetic Map7q11NCBI
Med16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,934,078 - 6,959,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,939,084 - 6,955,885 (+)NCBIChiLan1.0ChiLan1.0
MED16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,771,543 - 57,782,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,777,827 - 57,782,819 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,573,573 - 57,584,839 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,513,804 - 58,525,092 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,514,422 - 58,525,087 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,568,647 - 57,579,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,048,361 - 58,059,617 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,251,302 - 58,262,567 (+)NCBIUU_Cfam_GSD_1.0
Med16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,463,817 - 217,482,056 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588355,353 - 370,859 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588352,723 - 370,898 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,492,501 - 77,509,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,490,953 - 77,526,872 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,470,547 - 77,506,670 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16617,998 - 638,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,275,509 - 8,298,538 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,695,316 - 7,713,603 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,695,401 - 7,713,603 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035161   ⟹   ENSPPAP00000012496
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,367 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035162   ⟹   ENSPPAP00000012497
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,367 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035163   ⟹   ENSPPAP00000012498
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,483 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035164   ⟹   ENSPPAP00000012499
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,639 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035169   ⟹   ENSPPAP00000012504
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,639 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035175   ⟹   ENSPPAP00000012509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19841,716 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035180   ⟹   ENSPPAP00000012514
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19845,081 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035182   ⟹   ENSPPAP00000012516
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19861,391 - 863,080 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035183   ⟹   ENSPPAP00000012517
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl19862,318 - 863,080 (-)Ensembl
RefSeq Acc Id: XM_055104309   ⟹   XP_054960284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,200,059 - 5,224,297 (-)NCBI
NHGRI_mPanPan1194,437,887 - 4,463,688 (-)NCBI
RefSeq Acc Id: XM_055104310   ⟹   XP_054960285
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,200,059 - 5,223,456 (-)NCBI
NHGRI_mPanPan1194,437,887 - 4,462,936 (-)NCBI
RefSeq Acc Id: XM_055104311   ⟹   XP_054960286
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,200,059 - 5,224,297 (-)NCBI
NHGRI_mPanPan1194,437,887 - 4,463,688 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000012504   ⟸   ENSPPAT00000035169
RefSeq Acc Id: ENSPPAP00000012499   ⟸   ENSPPAT00000035164
RefSeq Acc Id: ENSPPAP00000012496   ⟸   ENSPPAT00000035161
RefSeq Acc Id: ENSPPAP00000012497   ⟸   ENSPPAT00000035162
RefSeq Acc Id: ENSPPAP00000012498   ⟸   ENSPPAT00000035163
RefSeq Acc Id: ENSPPAP00000012516   ⟸   ENSPPAT00000035182
RefSeq Acc Id: ENSPPAP00000012517   ⟸   ENSPPAT00000035183
RefSeq Acc Id: ENSPPAP00000012514   ⟸   ENSPPAT00000035180
RefSeq Acc Id: ENSPPAP00000012509   ⟸   ENSPPAT00000035175
RefSeq Acc Id: XP_054960286   ⟸   XM_055104311
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A5E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054960284   ⟸   XM_055104309
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AA29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054960285   ⟸   XM_055104310
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AA29 (UniProtKB/TrEMBL)
Protein Domains
Mediator complex subunit 16 C-terminal   Mediator complex subunit Med16 N-terminal   Mediator of RNA polymerase II transcription subunit


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035161.1 UniProtKB/TrEMBL
  ENSPPAT00000035162.1 UniProtKB/TrEMBL
  ENSPPAT00000035163.1 UniProtKB/TrEMBL
  ENSPPAT00000035164.1 UniProtKB/TrEMBL
  ENSPPAT00000035169.1 UniProtKB/TrEMBL
  ENSPPAT00000035175.1 UniProtKB/TrEMBL
  ENSPPAT00000035180.1 UniProtKB/TrEMBL
  ENSPPAT00000035182.1 UniProtKB/TrEMBL
  ENSPPAT00000035183.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro MED16_bridge UniProtKB/TrEMBL
  Mediator_Med16 UniProtKB/TrEMBL
  Mediator_Med16 UniProtKB/TrEMBL
  Mediator_Med16_C UniProtKB/TrEMBL
  Quinoprot_gluc/sorb_DH UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene MED16 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16 UniProtKB/TrEMBL
  PTHR13224 UniProtKB/TrEMBL
Pfam Med16 UniProtKB/TrEMBL
  Med16_bridge UniProtKB/TrEMBL
  Med16_C UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50952 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A2R9A5C8_PANPA UniProtKB/TrEMBL
  A0A2R9A5C9_PANPA UniProtKB/TrEMBL
  A0A2R9A5D3_PANPA UniProtKB/TrEMBL
  A0A2R9A5D8_PANPA UniProtKB/TrEMBL
  A0A2R9A5E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AA29 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AA51_PANPA UniProtKB/TrEMBL
  A0A2R9AAM9_PANPA UniProtKB/TrEMBL
  A0A2R9AAQ0_PANPA UniProtKB/TrEMBL