PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) Pan paniscus
Analyze
Symbol: PIK3R2
Name: phosphoinositide-3-kinase regulatory subunit 2
RGD ID: 11779533
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphotyrosine residue binding (inferred); INVOLVED IN negative regulation of cell migration involved in sprouting angiogenesis (ortholog); positive regulation of cell adhesion (ortholog); regulation of actin filament polymerization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH colon cancer (ortholog); Colonic Neoplasms (ortholog); Developmental Disabilities (ortholog); FOUND IN phosphatidylinositol 3-kinase complex, class IA (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 3-kinase regulatory subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,608,470 - 18,624,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PIK3R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,608,470 - 18,624,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensemblpanpan1.1panPan2
PIK3R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,153,163 - 18,170,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,153,163 - 18,170,532 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,263,973 - 18,281,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,125,016 - 18,142,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,125,015 - 18,142,343NCBI
Celera1918,165,735 - 18,183,085 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,827,466 - 17,844,856 (+)NCBIHuRef
CHM1_11918,263,528 - 18,280,901 (+)NCBICHM1_1
T2T-CHM13v2.01918,287,263 - 18,304,664 (+)NCBIT2T-CHM13v2.0
Pik3r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,220,820 - 71,229,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,220,820 - 71,229,357 (-)EnsemblGRCm39 Ensembl
GRCm38870,768,176 - 70,776,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,292,080 - 73,300,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,697,168 - 73,705,670 (-)NCBIMGSCv36mm8
Celera873,329,482 - 73,338,028 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pik3r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,699,389 - 18,708,045 (+)NCBIGRCr8
mRatBN7.21618,665,517 - 18,674,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,707,923 - 18,716,460 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,840,602 - 19,849,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,760,867 - 18,769,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,415,109 - 20,424,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,273,500 - 20,282,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,171,101 - 19,179,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,171,098 - 19,179,648 (+)NCBI
Celera1618,857,756 - 18,866,282 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pik3r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,234,111 - 3,241,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,234,111 - 3,241,445 (-)NCBIChiLan1.0ChiLan1.0
PIK3R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,826,037 - 44,838,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBIUU_Cfam_GSD_1.0
Pik3r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,461,387 - 203,472,734 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,010,488 - 3,021,920 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,010,526 - 3,021,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,637,371 - 59,652,073 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,637,363 - 59,652,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,195,762 - 59,210,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,620,673 - 16,637,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,621,606 - 16,636,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,738,902 - 2,757,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,513,969 - 1,523,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,513,916 - 1,523,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034946868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000032599   ⟹   ENSPPAP00000009952
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032601   ⟹   ENSPPAP00000009954
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,611,179 - 18,621,015 (+)Ensembl
RefSeq Acc Id: XM_034946868   ⟹   XP_034802759
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBI
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBI
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034802759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000009952.1
  ENSPPAP00000009954.1
Reference Protein Sequences
RefSeq Acc Id: XP_034802759   ⟸   XM_034946868
- UniProtKB: A0A2R8ZYB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000009952   ⟸   ENSPPAT00000032599
RefSeq Acc Id: ENSPPAP00000009954   ⟸   ENSPPAT00000032601
Protein Domains
Rho-GAP   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028206 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032599.1 UniProtKB/TrEMBL
  ENSPPAT00000032601.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro PI3K_P85_iSH2 UniProtKB/TrEMBL
  PI3K_p85beta_SH3 UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene PIK3R2 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS PI3KINASEP85 UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R8ZYB8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A2D2_PANPA UniProtKB/TrEMBL