LONP2 (lon peptidase 2, peroxisomal) - Rat Genome Database

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Gene: LONP2 (lon peptidase 2, peroxisomal) Pan paniscus
Analyze
Symbol: LONP2
Name: lon peptidase 2, peroxisomal
RGD ID: 11779066
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); ATP-dependent peptidase activity (inferred); INVOLVED IN protein catabolic process (inferred); protein import into peroxisome matrix (inferred); protein processing (inferred); ASSOCIATED WITH BURATTI-HAREL SYNDROME (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN peroxisomal matrix (ortholog); peroxisome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lon protease homolog 2, peroxisomal
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21857,707,121 - 57,822,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11663,612,489 - 63,727,551 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01628,513,060 - 28,628,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11647,405,018 - 47,519,636 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1647,405,018 - 47,511,124 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)
peroxisomal matrix  (IEA,ISO)
peroxisome  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LONP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21857,707,121 - 57,822,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11663,612,489 - 63,727,551 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01628,513,060 - 28,628,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11647,405,018 - 47,519,636 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1647,405,018 - 47,511,124 (+)Ensemblpanpan1.1panPan2
LONP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381648,244,300 - 48,363,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1648,244,300 - 48,363,122 (+)EnsemblGRCh38hg38GRCh38
GRCh371648,278,211 - 48,396,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361646,835,712 - 46,944,908 (+)NCBINCBI36Build 36hg18NCBI36
Celera1632,785,336 - 32,894,994 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1634,168,508 - 34,278,108 (+)NCBIHuRef
CHM1_11649,686,077 - 49,795,271 (+)NCBICHM1_1
T2T-CHM13v2.01654,041,108 - 54,160,261 (+)NCBIT2T-CHM13v2.0
Lonp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39887,350,672 - 87,443,264 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl887,350,672 - 87,450,501 (+)EnsemblGRCm39 Ensembl
GRCm38886,624,043 - 86,716,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl886,624,043 - 86,723,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv37889,147,942 - 89,240,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36889,514,212 - 89,606,741 (+)NCBIMGSCv36mm8
Celera890,889,925 - 90,982,551 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map842.1NCBI
Lonp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81936,580,736 - 36,672,242 (-)NCBIGRCr8
mRatBN7.21920,407,475 - 20,498,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1920,407,477 - 20,499,014 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1922,092,999 - 22,183,644 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01927,287,495 - 27,378,146 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01930,248,387 - 30,339,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01921,400,736 - 21,492,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1921,400,740 - 21,492,556 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01932,410,037 - 32,502,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,785,263 - 21,838,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11921,750,690 - 21,843,593 (-)NCBI
Celera1920,319,040 - 20,370,411 (-)NCBICelera
Cytogenetic Map19p11NCBI
Lonp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,991,371 - 7,084,008 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554746,991,371 - 7,084,008 (-)NCBIChiLan1.0ChiLan1.0
LONP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1266,714,247 - 66,808,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl266,714,252 - 66,808,403 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha263,290,418 - 63,384,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0267,272,494 - 67,366,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl267,272,201 - 67,367,011 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1264,086,050 - 64,180,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,109,532 - 65,203,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,997,485 - 66,091,550 (-)NCBIUU_Cfam_GSD_1.0
Lonp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934958,004,635 - 58,108,352 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364751,480,670 - 1,584,445 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364751,480,723 - 1,584,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LONP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl636,372,599 - 36,466,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1636,372,596 - 36,466,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2631,800,795 - 31,827,138 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LONP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1534,050,284 - 34,160,363 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl534,050,446 - 34,160,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604742,370,065 - 42,485,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lonp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249142,041,213 - 2,155,669 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249142,041,353 - 2,155,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000042379   ⟹   ENSPPAP00000019610
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1647,405,018 - 47,511,124 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042382   ⟹   ENSPPAP00000019613
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1647,405,018 - 47,511,124 (+)Ensembl
RefSeq Acc Id: XM_003819801   ⟹   XP_003819849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21857,707,121 - 57,816,083 (+)NCBI
NHGRI_mPanPan11663,612,489 - 63,721,459 (+)NCBI
Mhudiblu_PPA_v01628,513,061 - 28,622,000 (+)NCBI
PanPan1.11647,405,018 - 47,511,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024925812   ⟹   XP_024781580
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21857,707,134 - 57,822,175 (+)NCBI
NHGRI_mPanPan11663,612,502 - 63,727,551 (+)NCBI
Mhudiblu_PPA_v01628,513,060 - 28,628,181 (+)NCBI
PanPan1.11647,405,018 - 47,519,636 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034940114   ⟹   XP_034796005
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21857,707,141 - 57,816,083 (+)NCBI
NHGRI_mPanPan11663,612,507 - 63,721,459 (+)NCBI
Mhudiblu_PPA_v01628,513,060 - 28,622,000 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003819849 (Get FASTA)   NCBI Sequence Viewer  
  XP_024781580 (Get FASTA)   NCBI Sequence Viewer  
  XP_034796005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000019610
  ENSPPAP00000019610.1
  ENSPPAP00000019613.1
RefSeq Acc Id: XP_003819849   ⟸   XM_003819801
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AV09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024781580   ⟸   XM_024925812
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034796005   ⟸   XM_034940114
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AR28 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000019610   ⟸   ENSPPAT00000042379
Ensembl Acc Id: ENSPPAP00000019613   ⟸   ENSPPAT00000042382
Protein Domains
Lon N-terminal   Lon proteolytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042379.1 UniProtKB/TrEMBL
  ENSPPAT00000042382.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  1.20.5.5270 UniProtKB/TrEMBL
  2.30.130.40 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  Lon_bac/euk-typ UniProtKB/TrEMBL
  Lon_lid UniProtKB/TrEMBL
  Lon_proteolytic UniProtKB/TrEMBL
  Lon_Prtase UniProtKB/TrEMBL
  Lon_prtase_N_sf UniProtKB/TrEMBL
  Lon_substr-bd UniProtKB/TrEMBL
  Lonp2_euk UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Peptidase_S16_AS UniProtKB/TrEMBL
  PUA-like_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
KEGG Report pps:100978594 UniProtKB/TrEMBL
NCBI Gene LONP2 ENTREZGENE
PANTHER LON PROTEASE HOMOLOG 2, PEROXISOMAL UniProtKB/TrEMBL
  PTHR10046 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  Lon_C UniProtKB/TrEMBL
  Lon_lid UniProtKB/TrEMBL
  LON_substr_bdg UniProtKB/TrEMBL
PIRSF Lon_proteas UniProtKB/TrEMBL
PRINTS ENDOLAPTASE UniProtKB/TrEMBL
PROSITE LON_N UniProtKB/TrEMBL
  LON_PROTEOLYTIC UniProtKB/TrEMBL
  LON_SER UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  LON UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
  SSF88697 UniProtKB/TrEMBL
UniProt A0A2R9AR28 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AV09 ENTREZGENE, UniProtKB/TrEMBL