ARHGAP45 (Rho GTPase activating protein 45) - Rat Genome Database

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Gene: ARHGAP45 (Rho GTPase activating protein 45) Pan paniscus
Analyze
Symbol: ARHGAP45
Name: Rho GTPase activating protein 45
RGD ID: 11775891
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); metal ion binding (inferred); INVOLVED IN regulation of small GTPase mediated signal transduction (inferred); signal transduction (inferred); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); disease of cellular proliferation (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100968015; LOC100971703; LOC100990706; LOC112437884; minor histocompatibility protein HA-1; minor histocompatibility protein HA-1-like; rho GTPase-activating protein 45; rho GTPase-activating protein 45-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,402,945 - 5,423,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,639,516 - 4,659,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,053,817 - 1,063,962 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
membrane  (IEA)
plasma membrane  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARHGAP45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,402,945 - 5,423,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,639,516 - 4,659,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,053,817 - 1,063,962 (+)NCBIpanpan1.1PanPan1.1panPan2
ARHGAP45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,065,959 - 1,086,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,065,923 - 1,086,628 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,065,958 - 1,086,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,018,174 - 1,037,627 (+)NCBINCBI36Build 36hg18NCBI36
Celera191,000,157 - 1,019,602 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19839,303 - 860,108 (+)NCBIHuRef
CHM1_1191,065,515 - 1,086,230 (+)NCBICHM1_1
T2T-CHM13v2.0191,030,624 - 1,051,294 (+)NCBIT2T-CHM13v2.0
Arhgap45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,852,505 - 79,867,305 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,852,487 - 79,867,306 (+)EnsemblGRCm39 Ensembl
GRCm381080,016,672 - 80,031,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,016,653 - 80,031,472 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,479,417 - 79,494,216 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,422,804 - 79,434,597 (+)NCBIMGSCv36mm8
Celera1081,031,479 - 81,046,279 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Arhgap45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,325,515 - 10,340,955 (-)NCBIGRCr8
mRatBN7.279,674,873 - 9,690,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,674,897 - 9,690,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,557,673 - 12,572,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,433,011 - 14,448,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,294,131 - 12,309,172 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,541,032 - 12,741,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,541,061 - 12,741,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,711,159 - 12,910,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,187,348 - 11,202,717 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,187,782 - 11,203,831 (-)NCBI
Celera77,850,690 - 7,865,940 (-)NCBICelera
Cytogenetic Map7q11NCBI
Arhgap45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,797,302 - 6,815,651 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,800,988 - 6,815,941 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,656,693 - 57,668,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,657,154 - 57,787,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,458,893 - 57,470,543 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,398,796 - 58,410,450 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,398,800 - 58,409,442 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,454,098 - 57,465,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,933,623 - 57,945,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,136,680 - 58,148,331 (-)NCBIUU_Cfam_GSD_1.0
Arhgap45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,342,748 - 217,356,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588478,811 - 491,455 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588478,708 - 492,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,342,156 - 77,356,837 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,342,153 - 77,355,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,641,818 - 77,655,498 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16823,109 - 842,697 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6823,154 - 846,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,013,711 - 8,034,490 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,558,355 - 7,570,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,557,878 - 7,572,700 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034946337   ⟹   XP_034802228
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,402,945 - 5,423,096 (+)NCBI
NHGRI_mPanPan1194,639,525 - 4,659,610 (+)NCBI
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBI
RefSeq Acc Id: XM_034946339   ⟹   XP_034802230
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,402,945 - 5,423,096 (+)NCBI
NHGRI_mPanPan1194,639,516 - 4,659,610 (+)NCBI
Mhudiblu_PPA_v01941,207 - 61,193 (-)NCBI
RefSeq Acc Id: XM_034946340   ⟹   XP_034802231
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,406,882 - 5,423,096 (+)NCBI
NHGRI_mPanPan1194,643,317 - 4,659,610 (+)NCBI
Mhudiblu_PPA_v01941,207 - 57,423 (-)NCBI
RefSeq Acc Id: XM_034946341   ⟹   XP_034802232
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,406,884 - 5,423,096 (+)NCBI
NHGRI_mPanPan1194,643,319 - 4,659,610 (+)NCBI
Mhudiblu_PPA_v01941,207 - 57,422 (-)NCBI
RefSeq Acc Id: XM_034946342   ⟹   XP_034802233
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,406,820 - 5,423,096 (+)NCBI
NHGRI_mPanPan1194,643,261 - 4,659,610 (+)NCBI
Mhudiblu_PPA_v01941,207 - 57,742 (-)NCBI
RefSeq Acc Id: XM_063600723   ⟹   XP_063456793
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,403,483 - 5,423,096 (+)NCBI
RefSeq Acc Id: XM_063600724   ⟹   XP_063456794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,403,423 - 5,423,096 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034802230   ⟸   XM_034946339
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034802228   ⟸   XM_034946337
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034802233   ⟸   XM_034946342
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034802231   ⟸   XM_034946340
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034802232   ⟸   XM_034946341
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063456794   ⟸   XM_063600724
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063456793   ⟸   XM_063600723
- Peptide Label: isoform X1
Protein Domains
F-BAR   Phorbol-ester/DAG-type   Rho-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026578 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000029639.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
NCBI Gene ARHGAP45 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 45 UniProtKB/TrEMBL
  SPERMATHECAL PHYSIOLOGY VARIANT UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A2R8ZS41_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 ARHGAP45  Rho GTPase activating protein 45  LOC100990706  rho GTPase-activating protein 45  Symbol and/or name change 5135510 APPROVED
2020-06-11 LOC100990706  rho GTPase-activating protein 45  LOC100968015  rho GTPase-activating protein 45-like  Data merged from RGD:11998142 737654 PROVISIONAL
2020-06-11 LOC100990706  rho GTPase-activating protein 45  LOC112437884  rho GTPase-activating protein 45-like  Data merged from RGD:13585124 737654 PROVISIONAL
2020-06-11 LOC100990706  rho GTPase-activating protein 45  LOC100971703  rho GTPase-activating protein 45-like  Data merged from RGD:11742818 737654 PROVISIONAL
2018-05-08 LOC100990706  rho GTPase-activating protein 45  ARHGAP45  Rho GTPase activating protein 45  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC100968015  rho GTPase-activating protein 45-like    minor histocompatibility protein HA-1-like  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC100971703  rho GTPase-activating protein 45-like    minor histocompatibility protein HA-1-like  Symbol and/or name change 5135510 APPROVED