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Gene: ISCU (iron-sulfur cluster assembly enzyme) Pan paniscus

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Symbol:

ISCU

Name:

iron-sulfur cluster assembly enzyme

RGD ID:

11774940

Description:

ENCODES a protein that exhibits ferrous iron binding (inferred); iron ion binding (inferred); iron-sulfur cluster binding (inferred); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); genetic disease (ortholog); myopathy (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrial [2Fe-2S] assembly complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

iron-sulfur cluster assembly enzyme ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; iron-sulfur cluster scaffold homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	116,622,727 - 116,629,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	116,619,125 - 116,625,859 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	106,132,987 - 106,140,879 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	109,529,162 - 109,537,053 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	109,529,162 - 109,537,053 (+)	Ensembl			panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

clear cell renal cell carcinoma (ISO)

genetic disease (ISO)

myopathy (ISO)

Myopathy with Lactic Acidosis, Hereditary (ISO)

pre-eclampsia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

[2Fe-2S] cluster assembly (IEA)

[4Fe-4S] cluster assembly (IEA,ISO)

intracellular iron ion homeostasis (IEA)

iron-sulfur cluster assembly (IEA)

negative regulation of iron ion import across plasma membrane (IEA)

positive regulation of mitochondrial electron transport, NADH to ubiquinone (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

mitochondrial [2Fe-2S] assembly complex (IEA)

mitochondrion (IEA)

Molecular Function

ferrous iron binding (IEA)

iron ion binding (IEA)

iron-sulfur cluster binding (IEA)

iron-sulfur cluster chaperone activity (IEA)

metal ion binding (IEA)

molecular adaptor activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondrial iron-sulfur cluster protein biogenesis pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ISCU
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	116,622,727 - 116,629,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	116,619,125 - 116,625,859 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	106,132,987 - 106,140,879 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	109,529,162 - 109,537,053 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	109,529,162 - 109,537,053 (+)	Ensembl			panPan2	panpan1.1

ISCU
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	108,561,463 - 108,569,384 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	108,562,582 - 108,569,368 (+)	Ensembl			hg38	GRCh38
GRCh37	12	108,955,239 - 108,963,160 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	107,480,512 - 107,487,273 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	12	108,625,685 - 108,632,553 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	106,020,849 - 106,027,716 (+)	NCBI		HuRef
CHM1_1	12	108,922,512 - 108,929,380 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	108,530,831 - 108,538,753 (+)	NCBI		T2T-CHM13v2.0

Iscu
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	113,910,479 - 113,916,349 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	113,910,809 - 113,916,349 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	113,772,418 - 113,778,288 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	113,772,748 - 113,778,288 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	114,222,821 - 114,228,291 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	114,033,811 - 114,039,281 (+)	NCBI		MGSCv36	mm8
Celera	5	110,873,936 - 110,879,406 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	55.55	NCBI

Iscu
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	48,512,852 - 48,518,696 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	48,512,852 - 48,518,696 (-)	Ensembl				GRCr8
mRatBN7.2	12	42,852,305 - 42,858,150 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	42,852,305 - 42,858,150 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	44,018,678 - 44,024,102 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	44,632,273 - 44,637,697 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	43,692,805 - 43,698,229 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	48,621,454 - 48,627,297 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	48,621,454 - 48,627,297 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	50,403,338 - 50,409,181 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	43,886,419 - 43,892,329 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	44,453,913 - 44,459,757 (-)	NCBI		Celera
RGSC_v3.1	12	43,749,819 - 43,755,677 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

Iscu
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	9,833,924 - 9,841,619 (+)	Ensembl
ChiLan1.0	NW_004955455	9,833,924 - 9,840,547 (+)	NCBI	ChiLan1.0	ChiLan1.0

ISCU
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	18,300,800 - 18,307,668 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	18,300,803 - 18,307,652 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	17,492,198 - 17,499,090 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	18,647,123 - 18,654,012 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	18,647,126 - 18,653,991 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	17,701,195 - 17,708,096 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	18,638,137 - 18,645,016 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	18,656,527 - 18,663,400 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Iscu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	144,977,307 - 144,983,670 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936769	491,530 - 498,692 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936769	492,024 - 498,587 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ISCU
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	42,216,111 - 42,222,711 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	42,216,103 - 42,222,570 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	44,761,391 - 44,767,990 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ISCU
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	103,753,175 - 103,760,168 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	103,753,189 - 103,760,364 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	141,335,350 - 141,342,158 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Iscu
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	11,808,640 - 11,816,400 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	11,808,789 - 11,815,269 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000031128 ⟹ ENSPPAP00000008493

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	109,529,162 - 109,537,053 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000031133 ⟹ ENSPPAP00000008497

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	109,531,804 - 109,535,389 (+)	Ensembl

RefSeq Acc Id:

XM_003832526 ⟹ XP_003832574

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	116,622,727 - 116,629,492 (+)	NCBI
NHGRI_mPanPan1	12	116,619,125 - 116,625,859 (+)	NCBI
Mhudiblu_PPA_v0	12	106,132,987 - 106,140,879 (+)	NCBI
PanPan1.1	12	109,529,162 - 109,537,053 (+)	NCBI

Sequence:

show sequence

AGAATTTGGCGCCATCTTGAGAAGGTCAAAGTGATTCTTCGATTAAATGCCTTACTTATCGCCT
AGTGTGACCTGGCGCTTGGGTTTACTCTCCCCAGCAACTGCGCCTCAAACGCAAAGAAAACTGC
AGGTCCTCGGGGAAGGATCGATTTCACCATTCAAGAGAAAAATCCATTTCCCAGATTCCTCCCC
TTTATGTAAACGTCTGGTACCTAGTAGACGTTAAATACACGTGAGTTTTCCGGTTTTATAAGAT
CACATACTGCAAACCAACAGTAAATTACATTAATACGCATTTCTTTAGAAATTCTTAATTGCTA
GGCACTGACATATAAATTGAGTTTGCTGTTTAGAGAGAAAAATAGACATATTCTTTTTTTTCAA
TCAGGACATGGTATTCGTTTCCTTCTTAAGCTTCCCACTTTTGAGGTAGGAAAGTATTGGTGTG
TGTCTCTATCTCTACCTTGCTCCCTCATTAGCAGGCTTAATGGGCAGGAATTATGTCTGTTTTG
CTTTCCGTTGGATCCCCGGGTCTAGTAGAGCGCCTTGACACATAGGTACTCGACACAGATGCTG
GCTTCATGATGAAGCAATTGTCCTCGAATTAATACAAAAGGGAAGATTCAGACTTAGCGAGCCG
GTACCATTCGTCTAGGGACACACAGCCAGGAAGGAACCGAACCAGGATTCTAACCCAGGATTAC
CCAAGTTCGAATTCTAATTGAACATAAGTCCTTAGCGACCTTGGACGGAGTTACTAAACTGCCC
TGAATCTCGGCTTCCTTAGCTGCAAAATAGGGTTAGGAAAAGTGGACTCGGTGCTCCTCTGCGC
CGCATTCCCGCAGCGGGCTTTGTGAAAGCGAACTTGAGCCCCACACTGCAGAAGCCTGAGGTCC
TGTCTCAACCAGAATCCAGCACCCAGGACAAGCCCTCCAACGACTTCAGACCTTCCCGCTCCCG
ACCCCGCCCGCCCCCGAGAGGCGTGGTCAAGGCGGGGCCAGAAGGCGGACGCGTGCACGGAGCG
GTAAGGCGCAGGCGCAAAGCTTCGGTGACGACAGAGAGGCGCGCTCCCAGCTCGGAGCCGACTC
GCAGACGCGCCCCGCCCCTCGGCGTCGCTCTGGACTGGCGCAGGCGCAAGCCGGCAAGATGGCG
GCGGCTGGGGCTGGCCGTCTGAGGCGGGCGGCATCGGCTCTGCTGCTGCGGAGCCCCCGCCTGC
CCGCCCGGGAGCTGTCGGCCCCGGCCCGACTCTATCACAAGAAGGTTGTTGATCATTATGAAAA
TCCTAGAAACGTGGGGTCCCTTGACAAGACATCTAAAAATGTTGGAACTGGACTGGTGGGGGCT
CCAGCATGTGGTGACGTAATGAAATTACAGATTCAAGTGGATGAAAAGGGGAAGATTGTGGATG
CTAGGTTTAAAACATTTGGCTGTGGTTCCGCAATTGCCTCCAGCTCATTAGCCACTGAATGGGT
GAAAGGAAAGACGGTGGAGGAAGCCTTGACTATCAAAAACACAGATATCGCCAAGGAGCTCTGC
CTTCCTCCCGTGAAACTGCACTGCTCCATGCTGGCTGAAGATGCAATCAAGGCCGCCCTGGCTG
ATTACAAATTGAAACAAGAACCCAAAAAAGGAGAGGCAGAGAAGAAATGAGCCCTCCCTCGGCG
AAGCCTCCAGCAGGCCACACCAGCTGTTTCCCACCTGCTGTGCAGTCACCTTAGATGTTCAGAA
GCCGCTTCCTCTCCACTGAAGAGCTATGAGATACGCACAATACTTGCTGTTCACGTTATGACTC
TCATGCAAGCAAAATACACAGTTTCATTGTTCTGAATCCTGTGGTTTCTTTCAGCCCACTTTTA
TCGCCTTAACCTAGTTAATGTATATTTTGAATTGTGTGTATGACCTCAGAACTGAAATTGATAA
TGAAGTTGCAAGTTTTGATAGCCCGTGAAGTGCATAAGTATCTAATTTTACCTGAATTGATTTG
GGGGGAAATTACCAGTAGAATGCCTTGGTCTGAATATTTGATAGAACCAATTGTTGTACATAAA
ACAGATCTGCGCATATATATATATATATATGTATAAAAAATAATAAAATAATGGAAGATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832574	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008493.1
	ENSPPAP00000008497.1
	ENSPPAP00050037173

RefSeq Acc Id:	XP_003832574 ⟸ XM_003832526
- UniProtKB:	A0A2R8ZZT4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAGAGRLRRAASALLLRSPRLPARELSAPARLYHKKVVDHYENPRNVGSLDKTSKNVGTGLV GAPACGDVMKLQIQVDEKGKIVDARFKTFGCGSAIASSSLATEWVKGKTVEEALTIKNTDIAKE LCLPPVKLHCSMLAEDAIKAALADYKLKQEPKKGEAEKK hide sequence

Ensembl Acc Id:

ENSPPAP00000008493 ⟸ ENSPPAT00000031128

Ensembl Acc Id:

ENSPPAP00000008497 ⟸ ENSPPAT00000031133

Protein Domains

NIF system FeS cluster assembly NifU N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027482	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050026924	ENTREZGENE
Ensembl Transcript	ENSPPAT00000031128.1	UniProtKB/TrEMBL
	ENSPPAT00000031133.1	UniProtKB/TrEMBL
	ENSPPAT00050057236	ENTREZGENE
Gene3D-CATH	3.90.1010.10	UniProtKB/TrEMBL
InterPro	ISC_FeS_clus_asmbl_IscU	UniProtKB/TrEMBL
	NIF_FeS_clus_asmbl_NifU_N	UniProtKB/TrEMBL
KEGG Report	pps:100991951	UniProtKB/TrEMBL
NCBI Gene	ISCU	ENTREZGENE
PANTHER	PTHR10093	UniProtKB/TrEMBL
Pfam	NifU_N	UniProtKB/TrEMBL
Superfamily-SCOP	SufE/NifU	UniProtKB/TrEMBL
UniProt	A0A2R8ZXI2_PANPA	UniProtKB/TrEMBL
	A0A2R8ZZT4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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