TLR7 (toll like receptor 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: TLR7 (toll like receptor 7) Pan paniscus
Analyze
Symbol: TLR7
Name: toll like receptor 7
RGD ID: 11772279
Description: ENCODES a protein that exhibits double-stranded RNA binding (inferred); pattern recognition receptor activity (inferred); single-stranded RNA binding (inferred); INVOLVED IN positive regulation of interleukin-6 production (ortholog); positive regulation of macrophage cytokine production (ortholog); regulation of protein phosphorylation (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH allergic contact dermatitis (ortholog); anogenital venereal wart (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); early phagosome (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: toll-like receptor 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,651,418 - 14,674,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,655,084 - 14,677,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,479,247 - 5,504,810 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X12,768,698 - 12,790,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX12,767,981 - 12,790,517 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18810425   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TLR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,651,418 - 14,674,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,655,084 - 14,677,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,479,247 - 5,504,810 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X12,768,698 - 12,790,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX12,767,981 - 12,790,517 (+)Ensemblpanpan1.1panPan2
TLR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,867,072 - 12,890,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX12,867,072 - 12,890,361 (+)EnsemblGRCh38hg38GRCh38
GRCh37X12,885,191 - 12,908,480 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,795,123 - 12,818,401 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X12,644,862 - 12,666,567NCBI
CeleraX16,999,208 - 17,022,486 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX10,651,692 - 10,675,129 (+)NCBIHuRef
CHM1_1X12,915,641 - 12,938,921 (+)NCBICHM1_1
T2T-CHM13v2.0X12,448,550 - 12,471,838 (+)NCBIT2T-CHM13v2.0
Tlr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X166,086,376 - 166,113,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX166,087,925 - 166,113,554 (-)EnsemblGRCm39 Ensembl
GRCm38X167,303,380 - 167,330,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,304,929 - 167,330,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,742,863 - 163,768,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X162,649,036 - 162,674,633 (-)NCBIMGSCv36mm8
CeleraX150,452,330 - 150,504,044 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.31NCBI
Tlr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,644,324 - 30,670,796 (+)NCBIGRCr8
mRatBN7.2X27,027,380 - 27,054,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX27,027,425 - 27,054,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,100,702 - 28,126,815 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,502,172 - 31,528,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,715,343 - 27,741,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,486,836 - 28,513,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,486,869 - 28,512,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,882,968 - 28,908,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X47,330,737 - 47,356,841 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX27,439,445 - 27,465,491 (+)NCBICelera
Cytogenetic MapXq13NCBI
Tlr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544424,850 - 443,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544424,897 - 443,562 (-)NCBIChiLan1.0ChiLan1.0
TLR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,331,243 - 9,360,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX9,314,815 - 9,359,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX9,290,888 - 9,316,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X9,283,446 - 9,312,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX9,285,506 - 9,311,834 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X9,270,957 - 9,296,384 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X9,310,224 - 9,335,853 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X9,302,542 - 9,328,038 (+)NCBIUU_Cfam_GSD_1.0
Tlr7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,593,498 - 2,611,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,607,508 - 2,610,675 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,593,544 - 2,610,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X9,573,178 - 9,576,987 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,472,850 - 10,476,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,348,520 - 11,372,132 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605613,140,418 - 13,165,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248821,375,216 - 1,379,705 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032215   ⟹   ENSPPAP00000009572
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX12,767,981 - 12,790,517 (+)Ensembl
RefSeq Acc Id: XM_003805682   ⟹   XP_003805730
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X14,651,418 - 14,674,103 (+)NCBI
NHGRI_mPanPan1X14,655,084 - 14,677,769 (+)NCBI
Mhudiblu_PPA_v0X5,479,247 - 5,504,810 (+)NCBI
PanPan1.1X12,768,698 - 12,790,517 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003805730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAG55058 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000009572
  ENSPPAP00000009572.1
Reference Protein Sequences
RefSeq Acc Id: XP_003805730   ⟸   XM_003805682
- UniProtKB: B3Y649 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000009572   ⟸   ENSPPAT00000032215
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032215.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100986249 UniProtKB/TrEMBL
NCBI Gene TLR7 ENTREZGENE
PANTHER TOLL-LIKE RECEPTOR 7 UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 7-RELATED UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt B3Y649 ENTREZGENE, UniProtKB/TrEMBL