INPP5K (inositol polyphosphate-5-phosphatase K) - Rat Genome Database
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Gene: INPP5K (inositol polyphosphate-5-phosphatase K) Pan paniscus
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Symbol: INPP5K
Name: inositol polyphosphate-5-phosphatase K
RGD ID: 11772076
Description: ENCODES a protein that exhibits inositol bisphosphate phosphatase activity (ortholog); inositol trisphosphate phosphatase activity (ortholog); phosphatidylinositol phosphate 5-phosphatase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH congenital muscular dystrophy with cataracts and intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: inositol polyphosphate 5-phosphatase K
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cAMP  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
dephosphorylation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
in utero embryonic development  (ISO)
inositol phosphate dephosphorylation  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of dephosphorylation  (ISO)
negative regulation of glucose transmembrane transport  (ISO)
negative regulation of glycogen (starch) synthase activity  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein targeting to membrane  (ISO)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO)
negative regulation of stress fiber assembly  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
phosphatidylinositol dephosphorylation  (ISO)
positive regulation of renal water transport  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of urine volume  (ISO)
protein localization to plasma membrane  (ISO)
regulation of glycogen biosynthetic process  (ISO)
response to insulin  (ISO)
ruffle assembly  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
INPP5K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0panPan3
INPP5K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl171,494,577 - 1,516,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38171,494,575 - 1,516,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37171,397,871 - 1,419,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,344,621 - 1,366,704 (-)NCBINCBI36hg18NCBI36
Celera171,413,368 - 1,435,621 (-)NCBI
Cytogenetic Map17p13.3NCBI
HuRef171,298,037 - 1,320,343 (-)NCBIHuRef
CHM1_1171,406,563 - 1,428,873 (-)NCBICHM1_1
Inpp5k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,519,893 - 75,539,691 (+)NCBIGRCm39mm39
GRCm39 Ensembl1175,521,814 - 75,539,697 (+)Ensembl
GRCm381175,629,067 - 75,648,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,630,988 - 75,648,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,444,522 - 75,462,367 (+)NCBIGRCm37mm9NCBIm37
MGSCv361175,447,215 - 75,465,060 (+)NCBImm8
Celera1183,140,156 - 83,157,894 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Inpp5k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,474,262 - 60,495,813 (+)NCBI
Rnor_6.0 Ensembl1063,776,378 - 63,795,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01063,775,639 - 63,796,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01064,209,340 - 64,228,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,953,425 - 62,971,016 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11062,967,047 - 62,984,638 (+)NCBI
Celera1059,503,324 - 59,523,140 (+)NCBICelera
Cytogenetic Map10q24NCBI
Inpp5k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBIChiLan1.0ChiLan1.0
INPP5K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl945,660,446 - 45,680,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1945,660,445 - 45,680,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Inpp5k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365387,641,485 - 7,662,033 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,717,907 - 47,738,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,602,564 - 49,623,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5K
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,171,059 - 1,192,241 (-)NCBI
ChlSab1.1 Ensembl161,170,899 - 1,191,965 (-)Ensembl
Inpp5k
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247864,213,430 - 4,236,930 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062475   ⟹   ENSPPAP00000039564
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062481   ⟹   ENSPPAP00000039570
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062488   ⟹   ENSPPAP00000039577
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,378,343 - 1,399,320 (-)Ensembl
RefSeq Acc Id: XM_003816840   ⟹   XP_003816888
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,312 - 1,399,373 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003816842   ⟹   XP_003816890
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,312 - 1,399,373 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,511 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969940   ⟹   XP_008968188
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,147 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969941   ⟹   XP_008968189
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,024 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969942   ⟹   XP_008968190
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,320 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969943   ⟹   XP_008968191
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,320 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969944   ⟹   XP_008968192
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,312 - 1,399,320 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969945   ⟹   XP_008968193
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,320 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969946   ⟹   XP_008968194
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1171,377,310 - 1,399,320 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034941224   ⟹   XP_034797115
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0171,477,511 - 1,499,544 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008968188   ⟸   XM_008969940
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003816888   ⟸   XM_003816840
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003816890   ⟸   XM_003816842
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008968192   ⟸   XM_008969944
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008968193   ⟸   XM_008969945
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008968191   ⟸   XM_008969943
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008968194   ⟸   XM_008969946
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008968190   ⟸   XM_008969942
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008968189   ⟸   XM_008969941
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034797115   ⟸   XM_034941224
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000039564   ⟸   ENSPPAT00000062475
RefSeq Acc Id: ENSPPAP00000039570   ⟸   ENSPPAT00000062481
RefSeq Acc Id: ENSPPAP00000039577   ⟸   ENSPPAT00000062488
Protein Domains
IPPc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000039564 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000039570 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000039577 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062475 UniProtKB/TrEMBL
  ENSPPAT00000062481 UniProtKB/TrEMBL
  ENSPPAT00000062488 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
KEGG Report pps:100976910 UniProtKB/TrEMBL
NCBI Gene INPP5K ENTREZGENE
Pfam Exo_endo_phos UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt A0A2R9CCA5_PANPA UniProtKB/TrEMBL
  A0A2R9CCG4_PANPA UniProtKB/TrEMBL
  A0A2R9CN19_PANPA UniProtKB/TrEMBL