INPP5K (inositol polyphosphate-5-phosphatase K) - Rat Genome Database

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Gene: INPP5K (inositol polyphosphate-5-phosphatase K) Pan paniscus
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Symbol: INPP5K
Name: inositol polyphosphate-5-phosphatase K
RGD ID: 11772076
Description: ENCODES a protein that exhibits inositol bisphosphate phosphatase activity (inferred); inositol trisphosphate phosphatase activity (inferred); inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (inferred); INVOLVED IN glucose homeostasis (ortholog); in utero embryonic development (ortholog); negative regulation of peptidyl-serine phosphorylation (ortholog); ASSOCIATED WITH congenital muscular dystrophy with cataracts and intellectual disability (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inositol polyphosphate 5-phosphatase K
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,065,156 - 9,087,254 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,031,426 - 11,053,955 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cAMP  (IEA)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hormone stimulus  (IEA)
cellular response to insulin stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
glucose homeostasis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
negative regulation by host of viral transcription  (IEA)
negative regulation of calcium ion transport  (IEA)
negative regulation of dephosphorylation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of glucose transmembrane transport  (IEA)
negative regulation of glycogen biosynthetic process  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of peptidyl-serine phosphorylation  (IEA,ISO)
negative regulation of peptidyl-threonine phosphorylation  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of protein phosphorylation  (IEA)
negative regulation of protein targeting to membrane  (IEA)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (IEA)
negative regulation of stress fiber assembly  (IEA)
phosphatidylinositol dephosphorylation  (IEA,ISO)
phosphatidylinositol metabolic process  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of renal water transport  (IEA)
positive regulation of urine volume  (IEA)
protein localization to plasma membrane  (IEA)
regulation of glycogen biosynthetic process  (IEA)
response to insulin  (IEA,ISO)
ruffle assembly  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
INPP5K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,065,156 - 9,087,254 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,031,426 - 11,053,955 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
INPP5K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,494,577 - 1,516,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,494,577 - 1,516,742 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,397,871 - 1,419,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,344,621 - 1,366,704 (-)NCBINCBI36Build 36hg18NCBI36
Celera171,413,368 - 1,435,621 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,298,037 - 1,320,343 (-)NCBIHuRef
CHM1_1171,406,563 - 1,428,873 (-)NCBICHM1_1
T2T-CHM13v2.0171,383,334 - 1,405,368 (-)NCBIT2T-CHM13v2.0
Inpp5k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,519,893 - 75,539,691 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,521,814 - 75,539,697 (+)EnsemblGRCm39 Ensembl
GRCm381175,629,067 - 75,648,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,630,988 - 75,648,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,444,522 - 75,462,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,447,215 - 75,465,060 (+)NCBIMGSCv36mm8
Celera1183,140,156 - 83,157,894 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Inpp5k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,974,183 - 60,995,047 (+)NCBIGRCr8
mRatBN7.21060,474,262 - 60,495,813 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,475,897 - 60,496,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,122,645 - 65,142,529 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,628,064 - 64,647,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,090,639 - 60,110,523 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,775,639 - 63,796,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,776,378 - 63,795,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,209,340 - 64,228,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,953,425 - 62,971,016 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,967,047 - 62,984,638 (+)NCBI
Celera1059,503,324 - 59,523,140 (+)NCBICelera
Cytogenetic Map10q24NCBI
Inpp5k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBIChiLan1.0ChiLan1.0
INPP5K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,660,445 - 45,680,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,660,446 - 45,680,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,812,547 - 44,832,619 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,488,250 - 46,508,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,487,348 - 46,508,366 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,258,657 - 45,278,900 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,553,108 - 45,573,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,606,572 - 45,626,642 (-)NCBIUU_Cfam_GSD_1.0
Inpp5k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,763,537 - 44,785,099 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,641,127 - 7,661,787 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,641,485 - 7,662,033 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,718,491 - 47,738,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,602,564 - 49,623,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5K
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,171,059 - 1,192,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,170,899 - 1,191,965 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,795,694 - 20,817,596 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5k
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,214,916 - 4,236,563 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,213,430 - 4,236,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000062475   ⟹   ENSPPAP00000039564
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062481   ⟹   ENSPPAP00000039570
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062488   ⟹   ENSPPAP00000039577
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,378,343 - 1,399,320 (-)Ensembl
RefSeq Acc Id: XM_003816840   ⟹   XP_003816888
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,087,254 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,053,955 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBI
PanPan1.1171,377,312 - 1,399,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969940   ⟹   XP_008968188
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,087,116 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,053,644 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,537 (-)NCBI
PanPan1.1171,377,310 - 1,399,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969941   ⟹   XP_008968189
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,087,194 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,053,460 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,539 (-)NCBI
PanPan1.1171,377,310 - 1,399,024 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969943   ⟹   XP_008968191
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,086,999 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,053,263 (-)NCBI
Mhudiblu_PPA_v0171,477,511 - 1,499,359 (-)NCBI
PanPan1.1171,377,310 - 1,399,320 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055101269   ⟹   XP_054957244
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,087,116 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,053,652 (-)NCBI
RefSeq Acc Id: XM_055101270   ⟹   XP_054957245
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,065,156 - 9,084,519 (-)NCBI
NHGRI_mPanPan11711,031,426 - 11,050,782 (-)NCBI
RefSeq Acc Id: XP_008968188   ⟸   XM_008969940
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003816888   ⟸   XM_003816840
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CCA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008968191   ⟸   XM_008969943
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008968189   ⟸   XM_008969941
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSPPAP00000039564   ⟸   ENSPPAT00000062475
RefSeq Acc Id: ENSPPAP00000039570   ⟸   ENSPPAT00000062481
RefSeq Acc Id: ENSPPAP00000039577   ⟸   ENSPPAT00000062488
RefSeq Acc Id: XP_054957244   ⟸   XM_055101269
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054957245   ⟸   XM_055101270
- Peptide Label: isoform X6

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062475.1 UniProtKB/TrEMBL
  ENSPPAT00000062481.1 UniProtKB/TrEMBL
  ENSPPAT00000062488.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2840 UniProtKB/TrEMBL
  3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  IP5 UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
KEGG Report pps:100976910 UniProtKB/TrEMBL
NCBI Gene INPP5K ENTREZGENE
PANTHER INOSITOL 5-PHOSPHATASE UniProtKB/TrEMBL
  INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K UniProtKB/TrEMBL
Pfam SKICH UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt A0A2R9CCA5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCG4_PANPA UniProtKB/TrEMBL
  A0A2R9CN19_PANPA UniProtKB/TrEMBL