SMPD1 (sphingomyelin phosphodiesterase 1) - Rat Genome Database

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Gene: SMPD1 (sphingomyelin phosphodiesterase 1) Pan paniscus
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Symbol: SMPD1
Name: sphingomyelin phosphodiesterase 1
RGD ID: 11771717
Description: ENCODES a protein that exhibits acid sphingomyelin phosphodiesterase activity (ortholog); sphingomyelin phosphodiesterase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to UV (ortholog); ceramide biosynthetic process (ortholog); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Gaucher's disease (ortholog); intellectual disability (ortholog); FOUND IN endolysosome (ortholog); endosome (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sphingomyelin phosphodiesterase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,205,278 - 6,209,950 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0116,521,812 - 6,526,349 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SMPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,205,278 - 6,209,950 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0116,521,812 - 6,526,349 (+)NCBIMhudiblu_PPA_v0panPan3
SMPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl116,390,440 - 6,394,998 (+)EnsemblGRCh38hg38GRCh38
GRCh38116,390,474 - 6,394,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,411,704 - 6,416,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,368,231 - 6,372,802 (+)NCBINCBI36hg18NCBI36
Build 34116,368,230 - 6,372,801NCBI
Celera116,530,711 - 6,535,296 (+)NCBI
Cytogenetic Map11p15.4NCBI
HuRef116,070,739 - 6,075,337 (+)NCBIHuRef
CHM1_1116,410,778 - 6,415,363 (+)NCBICHM1_1
Smpd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,203,567 - 105,207,596 (+)NCBIGRCm39mm39
GRCm39 Ensembl7105,203,567 - 105,207,596 (+)Ensembl
GRCm387105,554,360 - 105,558,389 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,554,360 - 105,558,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,702,874 - 112,706,903 (+)NCBIGRCm37mm9NCBIm37
MGSCv367105,428,236 - 105,432,203 (+)NCBImm8
Celera7105,825,502 - 105,829,531 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.9NCBI
Smpd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21159,892,946 - 159,896,789 (+)NCBI
Rnor_6.0 Ensembl1170,383,682 - 170,387,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01170,383,682 - 170,387,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01177,389,588 - 177,393,431 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,278,970 - 163,282,813 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1157,825,620 - 157,829,463 (+)NCBICelera
Cytogenetic Map1q32NCBI
Smpd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,117,930 - 22,121,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,117,929 - 22,121,744 (+)NCBIChiLan1.0ChiLan1.0
SMPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,714,418 - 29,719,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,714,557 - 29,719,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,416,446 - 29,421,072 (+)NCBI
ROS_Cfam_1.02130,540,703 - 30,545,329 (+)NCBI
UMICH_Zoey_3.12129,861,608 - 29,866,232 (+)NCBI
UNSW_CanFamBas_1.02130,027,386 - 30,032,012 (+)NCBI
UU_Cfam_GSD_1.02130,222,733 - 30,227,359 (+)NCBI
Smpd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,222,931 - 56,227,200 (-)NCBI
SpeTri2.0NW_004936842448,315 - 452,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,324,091 - 3,328,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,324,091 - 3,328,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,961,624 - 3,964,422 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMPD1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,431,677 - 58,436,233 (-)NCBI
ChlSab1.1 Ensembl158,432,068 - 58,436,236 (-)Ensembl
Vero_WHO_p1.0NW_023666038156,257,313 - 156,261,990 (-)NCBI
Smpd1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248177,909,777 - 7,913,419 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_003819073   ⟹   XP_003819121
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1116,205,278 - 6,209,950 (+)NCBI
Mhudiblu_PPA_v0116,521,812 - 6,526,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003819074   ⟹   XP_003819122
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1116,205,278 - 6,209,950 (+)NCBI
Mhudiblu_PPA_v0116,521,823 - 6,526,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024930642   ⟹   XP_024786410
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1116,206,997 - 6,209,950 (+)NCBI
Mhudiblu_PPA_v0116,521,855 - 6,526,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034932042   ⟹   XP_034787933
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0116,521,823 - 6,526,349 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003819121 (Get FASTA)   NCBI Sequence Viewer  
  XP_003819122 (Get FASTA)   NCBI Sequence Viewer  
  XP_024786410 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787933 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003819122   ⟸   XM_003819074
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003819121   ⟸   XM_003819073
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024786410   ⟸   XM_024930642
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_034787933   ⟸   XM_034932042
- Peptide Label: isoform X2
Protein Domains
Saposin B-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031490 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000016788 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039486 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
InterPro ASMase/PPN1_MPP UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  Saposin-like UniProtKB/TrEMBL
  SaposinB_dom UniProtKB/TrEMBL
  Sphingomy_PDE UniProtKB/TrEMBL
NCBI Gene SMPD1 ENTREZGENE
Pfam Metallophos UniProtKB/TrEMBL
PIRSF Sphingomy_PDE UniProtKB/TrEMBL
PROSITE SAP_B UniProtKB/TrEMBL
SMART SapB UniProtKB/TrEMBL
Superfamily-SCOP SSF47862 UniProtKB/TrEMBL
UniProt A0A2R9AIC5_PANPA UniProtKB/TrEMBL