RHOJ (ras homolog family member J)

Gene: RHOJ (ras homolog family member J) Pan paniscus

Analyze

Symbol:

RHOJ

Name:

ras homolog family member J

RGD ID:

11771632

Description:

ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); regulation of cell shape (ortholog); retina vasculature morphogenesis in camera-type eye (ortholog); ASSOCIATED WITH cardiomyopathy (ortholog); Colonic Neoplasms (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

rho-related GTP-binding protein RhoJ

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	64,312,926 - 64,401,985 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	63,529,470 - 63,618,501 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	43,783,185 - 43,872,000 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	62,039,436 - 62,126,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	62,039,418 - 62,126,908 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cardiomyopathy (ISO)

Colonic Neoplasms (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

Cdc42 protein signal transduction (IEA)

endocytosis (IEA)

establishment or maintenance of cell polarity (IEA)

positive regulation of cell migration involved in sprouting angiogenesis (IEA)

regulation of cell shape (IEA,ISO)

regulation of endothelial cell migration (IEA)

regulation of sprouting angiogenesis (IEA)

retina vasculature morphogenesis in camera-type eye (IEA,ISO)

Rho protein signal transduction (IEA,ISO)

small GTPase-mediated signal transduction (IEA)

Cellular Component

plasma membrane (IEA)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RHOJ
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	64,312,926 - 64,401,985 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	63,529,470 - 63,618,501 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	43,783,185 - 43,872,000 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	62,039,436 - 62,126,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	62,039,418 - 62,126,908 (+)	Ensembl	panpan1.1		panPan2

RHOJ
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	63,204,443 - 63,293,508 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	63,204,114 - 63,293,508 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	63,671,161 - 63,760,226 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	62,740,898 - 62,828,312 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	62,740,897 - 62,828,312	NCBI
Celera	14	43,721,815 - 43,809,227 (+)	NCBI		Celera
Cytogenetic Map	14	q23.2	NCBI
HuRef	14	43,837,525 - 43,926,644 (+)	NCBI		HuRef
CHM1_1	14	63,610,149 - 63,699,277 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	57,411,795 - 57,500,853 (+)	NCBI		T2T-CHM13v2.0

Rhoj
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	75,355,087 - 75,448,229 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	75,355,096 - 75,448,230 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	75,308,313 - 75,401,455 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	75,308,322 - 75,401,456 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	76,409,300 - 76,502,442 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	76,227,153 - 76,320,295 (+)	NCBI		MGSCv36	mm8
Celera	12	76,399,403 - 76,485,627 (+)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	32.63	NCBI

Rhoj
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	99,771,104 - 99,853,366 (+)	NCBI		GRCr8
mRatBN7.2	6	94,035,307 - 94,117,642 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,035,483 - 94,118,275 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	94,433,053 - 94,514,759 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	94,731,575 - 94,813,279 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	94,160,435 - 94,242,141 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	98,284,361 - 98,367,122 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	98,284,170 - 98,367,756 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	107,702,937 - 107,785,252 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	97,911,744 - 97,995,878 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	97,915,199 - 97,999,311 (+)	NCBI
Celera	6	92,465,594 - 92,546,315 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

Rhoj
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	6,476,822 - 6,564,988 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955466	6,476,822 - 6,564,890 (-)	NCBI	ChiLan1.0	ChiLan1.0

RHOJ
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	37,803,460 - 37,880,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	37,803,717 - 37,882,207 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	37,560,607 - 37,637,620 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	38,030,147 - 38,108,957 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	38,030,239 - 38,108,013 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	37,647,128 - 37,724,061 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	37,726,711 - 37,803,608 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	38,079,926 - 38,156,853 (+)	NCBI		UU_Cfam_GSD_1.0

Rhoj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	67,013,327 - 67,097,318 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	7,094,513 - 7,174,371 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	7,094,522 - 7,174,371 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHOJ
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	194,760,939 - 194,844,356 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	194,761,588 - 194,843,867 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	216,775,655 - 216,796,767 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RHOJ
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	40,352,967 - 40,458,993 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	40,353,075 - 40,459,484 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	28,578,164 - 28,680,770 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rhoj
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	37,736,256 - 37,832,008 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	37,720,834 - 37,831,907 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003831624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034937668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000033615 ⟹ ENSPPAP00000010960

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	62,039,418 - 62,126,908 (+)	Ensembl

RefSeq Acc Id:

XM_003831624 ⟹ XP_003831672

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	64,312,926 - 64,401,985 (+)	NCBI
NHGRI_mPanPan1	14	63,529,482 - 63,618,501 (+)	NCBI
Mhudiblu_PPA_v0	14	43,783,192 - 43,872,000 (+)	NCBI
PanPan1.1	14	62,039,436 - 62,126,908 (+)	NCBI

Sequence:

show sequence

AGCTCCCATTGTTGCAGCCTTCCTCAGCCCACTGATCCTAATATGGAATGCAGCAGGAAACCCA
TGATTTCCTGACACTCGGCAAGCTGGAGGAAGCAAGGGGAAAACACTCCATTAAAAAGCCCAGC
TTTCCTCCATGTTAGATGTGACTTGGAAAATGAGAAAGATTTAGCAAAATTCCACCGTGTCTTT
CGCCAGGCTAGAGACAGGGAGAGCAGAGTAAAACCCTCAGGCTGCTGAAATTTCTAGGCTGTTA
GGAAGCCCCTCGAATTCTGTGAAAATGAGGGTTTCTTAACTCACACTGAGAGCGGAAAGGGGCA
GACCCTTTTCATAACTCCCTCAAGTGTGTGTTACCTTTCTTCACCAGCATGGTAAGCAACAGGA
CATATCCCAGCCTCGGACATGTCTGTATGATCCAAGGTACCCAAAGTCAGACAGAGTAAACTCA
AGCCTGGCACTGGCTTTCTGCCGCTTCATGTGCTTTGGAAAAAGCAGGAGAAGCAATAGCAGCA
GGAGTCCCCAGCAGCTGGAGCCGCAAGAATGAACTGCAAAGAGGGAACTGACAGCAGCTGCGGC
TGCAGGGGCAACGACGAGAAGAAGATGTTGAAGTGTGTGGTGGTGGGGGACGGTGCCGTGGGGA
AAACCTGCCTGCTGATGAGCTACGCCAACGACGCCTTCCCAGAGGAATACGTGCCCACTGTGTT
TGACCACTATGCAGTTACTGTGACTGTGGGAGGCAAACAACACTTGCTCGGACTGTATGACACT
GCGGGACAGGAGGACTACAACCAGCTGAGGCCGCTCTCCTACCCCAACACGGATGTGTTTTTGA
TCTGCTTCTCTGTCGTAAACCCTGCCTCTTACCACAATGTCCAGGAGGAATGGGTCCCCGAGCT
CAAGGACTGCATGCCTCACGTGCCTTATGTCCTCATAGGGACCCAGATTGATCTCCGTGATGAC
CCAAAAACCTTGGCCCGTTTGCTGTATATGAAAGAGAAACCTCTCACTTACGAGCATGGTGTGA
AGCTCGCAAAAGCGATCGGAGCACAGTGCTACTTGGAATGTTCAGCTCTGACTCAGAAAGGTCT
CAAAGCGGTTTTTGATGAAGCAATCCTCACCATTTTCCACCCCAAGAAAAAGAAGAAACGCTGT
TCTGAGGGTCACAGCTGCTGTTCAATTATCTGAGGTTGTCTGGGACCTGCCTCCACCCCATCCA
GGGATGAGAATGGCAGCCAATCTCTGTGGCCAAGCTCCAGCCAAAAAGGAGGGCACGACCAGAA
AGGAACTCCCTTTGCACGGAGGCTTGCCCCATCACCCTCTGAGCCCTCCCAACACAGCACACTA
GTCAGCCCACTGCCACGACCTCCCTGCCAGCCAGAAGCATCCGTACTGCACGCTCTCTGAGAAT
GCTGGGCCTGGATTGCAGACAGTGCCGCTGCTGATCGCATCAAAAACAAAGTCAAAGGCCATCT
CACATTTTACAAATCCCCAGCTCATGAACGTGAAGCTGATAGGAAATCACCCCAGGGAACCTGA
AAAAGAAACTTGGTTCCTCTATTGGTGGCCTTACTTGATGTCTTTTACAAAACTTGGGACTACA
ATACTAACCTTTTTTTCTGAATCTGCTGTTCTACCCATGTGTCTCACATTCATTTGTATTATTT
CAAGAAATGTACTAATTTCCAGTTCACTCAGGCCTTAAAAATCCATACCAAATTAGCCTAAAGA
CAAGGCATTTTATATTCGTTTCTATTTTCAGCATGTTTCTACCAAAGCTATTAGAACCAACACG
TACCTCTGAATGCCTGATTATAAGAAGACACGAGAAGACTTTAAAAGTTTTGGAAATTTACAGA
GCCATGATTTTTGAACCTGATTGAAAGAAAACCATCCGAATTGTTGCAGGTCCACATTTTTGCC
AAAGATGCACTCTATAGATGCTTAGCAGTGGCCTGATTTTTTTCCATGTATTGCCACGACAAAC
TAAAAATGAACTGTGTTTAAGAATGTAGTATTTCTGTTTTTCATCCAAGTTGATTGGGGGAAGA
ATGTGGCAGGATCCATCTTTTACAGTATTGTGTATTCAGTAAAGTGGACATTCCTGCTCCTCCC
TTCCCCCATTGCATGCCCTCTTCCTCCCTTGATTTCACTTTCTCTCATGCCCGGATCCTTTTAT
TCTCCCCAGTTATAACCCAGTTATAAAAGAAAGATCTGAGCATAAAGATACGTGTTTAAAAATA
ACTAAAAGTAAAGGAAAGTGCCTTAATTTTTC

hide sequence

RefSeq Acc Id:

XM_034937668 ⟹ XP_034793559

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	64,312,926 - 64,401,985 (+)	NCBI
NHGRI_mPanPan1	14	63,529,470 - 63,618,501 (+)	NCBI
Mhudiblu_PPA_v0	14	43,783,185 - 43,870,862 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003831672	(Get FASTA)	NCBI Sequence Viewer
	XP_034793559	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000010960
	ENSPPAP00000010960.1

RefSeq Acc Id:	XP_003831672 ⟸ XM_003831624
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A5D1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTVTV GGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELKDCMPHVPY VLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQKGLKAVFDEAIL TIFHPKKKKKRCSEGHSCCSII hide sequence

RefSeq Acc Id:	XP_034793559 ⟸ XM_034937668
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSPPAP00000010960 ⟸ ENSPPAT00000033615

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000028695	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000033615.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
	Small_GTPase_Rho	UniProtKB/TrEMBL
KEGG Report	pps:100991266	UniProtKB/TrEMBL
NCBI Gene	RHOJ	ENTREZGENE
PANTHER	PTHR24072	UniProtKB/TrEMBL
	RHO-RELATED GTP-BINDING PROTEIN RHOJ	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A2R9A5D1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD