LOC100978423 (tryptase beta-2) - Rat Genome Database

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Gene: LOC100978423 (tryptase beta-2) Pan paniscus
Analyze
Symbol: LOC100978423
Name: tryptase beta-2
RGD ID: 11755188
Description: ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); idiopathic generalized epilepsy (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC117977980; TPSB2; tryptase alpha/beta-1; tryptase beta 2; tryptase delta-like
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,484,128 - 1,485,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,264,473 - 5,266,322 (-)NCBINHGRI_mPanPan1
PanPan1.1161,234,218 - 1,236,068 (-)NCBIpanpan1.1PanPan1.1panPan2


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC100978423
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,484,128 - 1,485,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,264,473 - 5,266,322 (-)NCBINHGRI_mPanPan1
PanPan1.1161,234,218 - 1,236,068 (-)NCBIpanpan1.1PanPan1.1panPan2
TPSB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,228,336 - 1,230,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,227,272 - 1,232,757 (-)EnsemblGRCh38hg38GRCh38
GRCh37161,278,336 - 1,280,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,218,337 - 1,220,186 (-)NCBINCBI36Build 36hg18NCBI36
Build 34161,230,940 - 1,232,555NCBI
Celera161,494,229 - 1,494,587 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,211,394 - 1,224,892 (-)NCBIHuRef
CHM1_1161,278,009 - 1,279,872 (-)NCBICHM1_1
T2T-CHM13v2.0161,243,646 - 1,245,495 (-)NCBIT2T-CHM13v2.0
Tpsb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,585,282 - 25,587,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,585,170 - 25,588,079 (+)EnsemblGRCm39 Ensembl
GRCm381725,366,308 - 25,368,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,366,305 - 25,369,098 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,503,278 - 25,505,037 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,093,933 - 25,095,692 (+)NCBIMGSCv36mm8
Celera1725,894,349 - 25,896,108 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Tpsb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,886,310 - 14,888,102 (+)NCBIGRCr8
mRatBN7.21014,381,779 - 14,383,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,382,013 - 14,383,569 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,122,492 - 19,124,284 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,611,363 - 18,613,155 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,110,546 - 14,112,338 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,722,672 - 14,724,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,722,756 - 14,724,600 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,539,018 - 14,540,810 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,613,118 - 14,614,917 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,613,117 - 14,614,917 (+)NCBI
Celera1014,053,492 - 14,055,284 (+)NCBICelera
Cytogenetic Map10q12NCBI
LOC110255206
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,633,270 - 40,635,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Expression


Sequence


RefSeq Acc Id: XM_008960952   ⟹   XP_008959200
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,484,128 - 1,485,978 (-)NCBI
NHGRI_mPanPan1165,264,473 - 5,266,322 (-)NCBI
PanPan1.1161,234,218 - 1,236,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014341614   ⟹   XP_014197100
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2181,484,128 - 1,485,821 (-)NCBI
NHGRI_mPanPan1165,264,491 - 5,266,165 (-)NCBI
PanPan1.1161,234,218 - 1,235,862 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008959200 (Get FASTA)   NCBI Sequence Viewer  
  XP_014197100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040017
  ENSPPAP00000040017.1
RefSeq Acc Id: XP_008959200   ⟸   XM_008960952
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_014197100   ⟸   XM_014341614
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CNX8 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042671 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062930.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene LOC100978423 ENTREZGENE
PANTHER TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
  TRYPTASE DELTA 1 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A2R9CNX8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 LOC100978423  tryptase beta-2  TPSB2  tryptase beta 2  Symbol and/or name change 5135510 APPROVED
2023-04-20 TPSB2  tryptase beta 2  LOC117977980  tryptase delta-like  Data merged from RGD:32728593 737654 PROVISIONAL
2020-07-01 TPSB2  tryptase beta 2  LOC100978423  tryptase alpha/beta-1  Symbol and/or name change 5135510 APPROVED