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Gene: FSCN3 (fascin actin-bundling protein 3) Pan paniscus

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Symbol:

FSCN3

Name:

fascin actin-bundling protein 3

RGD ID:

11750133

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN actin filament bundle assembly (inferred); actin filament organization (inferred); cell migration (inferred); ASSOCIATED WITH hypospadias (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN actin cytoskeleton (inferred); cell projection membrane (inferred); cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fascin homolog 3, actin-bundling protein, testicular; fascin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	164,452,844 - 164,461,849 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	16,463,095 - 16,471,201 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	119,589,219 - 119,597,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	132,244,268 - 132,252,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	132,244,268 - 132,250,913 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypospadias (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IEA)

actin filament organization (IEA)

cell migration (IEA)

establishment or maintenance of cell polarity (IEA)

Cellular Component

actin cytoskeleton (IEA)

cell projection membrane (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

filopodium (IEA)

growth cone (IEA)

lamellipodium (IEA)

microvillus (IEA)

ruffle (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

protein-macromolecule adaptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FSCN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	164,452,844 - 164,461,849 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	16,463,095 - 16,471,201 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	119,589,219 - 119,597,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	132,244,268 - 132,252,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	132,244,268 - 132,250,913 (+)	Ensembl	panpan1.1		panPan2

FSCN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	127,593,736 - 127,602,144 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	127,591,409 - 127,602,144 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	127,233,790 - 127,242,198 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	127,020,925 - 127,029,079 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	126,827,639 - 126,835,794	NCBI
Celera	7	122,037,417 - 122,045,564 (+)	NCBI		Celera
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	121,594,759 - 121,602,743 (+)	NCBI		HuRef
CHM1_1	7	127,166,986 - 127,175,152 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	128,905,415 - 128,913,829 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	126,617,134 - 126,625,289 (+)	NCBI

Fscn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	28,427,888 - 28,438,621 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	28,427,788 - 28,438,621 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	28,427,870 - 28,438,622 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	28,427,789 - 28,438,622 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	28,377,901 - 28,388,622 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	28,377,911 - 28,388,632 (+)	NCBI		MGSCv36	mm8
Celera	6	28,434,941 - 28,445,662 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	11.99	NCBI

Fscn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	58,008,124 - 58,017,674 (+)	NCBI		GRCr8
mRatBN7.2	4	57,042,797 - 57,052,224 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	57,042,797 - 57,052,404 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	62,026,051 - 62,035,423 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	57,942,002 - 57,951,372 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	56,344,097 - 56,353,471 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	55,719,976 - 55,729,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	55,720,010 - 55,729,457 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	55,467,449 - 55,476,891 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	55,298,103 - 55,307,523 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	55,548,259 - 55,557,678 (+)	NCBI
Celera	4	52,154,383 - 52,163,752 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Fscn3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	8,648,582 - 8,654,493 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	8,649,022 - 8,656,899 (+)	NCBI	ChiLan1.0	ChiLan1.0

FSCN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	8,719,857 - 8,730,881 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	8,722,069 - 8,730,729 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	8,412,681 - 8,423,700 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	8,493,397 - 8,504,409 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	8,498,393 - 8,504,258 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	8,697,622 - 8,708,643 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	8,431,978 - 8,443,113 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	8,585,848 - 8,596,872 (-)	NCBI		UU_Cfam_GSD_1.0

Fscn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	53,671,359 - 53,680,429 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	14,795,129 - 14,801,401 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	14,794,876 - 14,803,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FSCN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	20,686,746 - 20,693,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	20,684,621 - 20,693,552 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,688,295 - 21,697,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FSCN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	96,407,983 - 96,416,313 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	96,409,005 - 96,414,922 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	6,990,607 - 6,999,054 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fscn3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	8,350,201 - 8,356,189 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	8,345,467 - 8,356,973 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000063997 ⟹ ENSPPAP00000041076

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	132,244,268 - 132,250,913 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000064000 ⟹ ENSPPAP00000041079

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	132,244,481 - 132,245,315 (+)	Ensembl

RefSeq Acc Id:

XM_003806051 ⟹ XP_003806099

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	164,452,844 - 164,461,849 (+)	NCBI
NHGRI_mPanPan1	7	16,463,095 - 16,471,201 (+)	NCBI
Mhudiblu_PPA_v0	7	119,589,219 - 119,597,360 (+)	NCBI
PanPan1.1	7	132,244,268 - 132,252,312 (+)	NCBI

Sequence:

show sequence

CCCCACTGTGGTGGGATAAGAGGCTGCCCTCACAGTCACAATGCTCCCGGGTCACAGAGGTGCT
GGGCCCCAGGCCAGCCTCTGCCTGGGAAGTTCTCTCTGGGAACATCTGGTGGGTGCTACAGGCC
CTATTCCAGGCCCTATGGCCTGTGGAACCTCACCACGGGGGGGAGGGCTGGGCCAGACGGAGAC
ATCACCTGTGGTGTCAGCCCCATGGATGAGACAGAGTGGATACACAGACATCCCAAGGCTGAGG
ACCTAAGGGTTGGGCTCATCAGCTGGGCAGGAACCTACCTCACCTTTGAGGCATGCAAGAATAC
AGTCACTGCAACTGCGAAGAGTTTGGGCAGGAGACAGACCTGGGAGATCTTGGTGAGCAATGAG
CATGAGACACAGGCCGTGGTGCGACTAAAGAGCGTGCAGGGCCTCTACCTGCTGTGTGAGTGTG
ATGGCACCGTGTGTTATGGCCGCCCAAGGACCAGCCACCACGGGTGCTTTCTACTGCGTTTCCA
CCGGAACAGCAAGTGGACCCTCCAGTGCCTAATCTCTGGTCGTTATTTGGAGTCCAATGGCAAG
GACGTGTTTTGCACTTCCCACGTCCTCTCAGCTTACCACATGTGGACCCCCCGACCAGCCCTCC
ATGTCCACGTGATCCTCTACAGCCCCATCCACCACTGCTATGCCCGGGCTGACCCCACTATGGG
CCGCATCTGGGTGGACGCAGCAGTTCCCTGCCTGGAGGAGTGTGGCTTCCTGTTGCATTTCCGA
GATGGATGCTACCACCTGGAGACCTCTACACACCACTTCTTGTCCCATGTAGACCGGCTGTTCT
CCCAACCCTCATCACAGACAGCTTTTCACATGCAAGTGCAGCCTGGAGGGCTTGTGGCACTGTG
TGATGGAGAAGGAGGCATGTTATATCCACAGGGCACACATCTGCTCTTGGGCATGGGCTGCAAC
CCCATGAGGGGTGAGGAGTGGTTCATCCTACAGCACTGCCCAACCTGGGTCAGCCTCAGGTCAA
AGACTGGGCGGTTCATCTCAGTCATCTACGATGGTGAGGTGCGTGCTGCTTCTGAGTGCTTAAA
CCCAATGTCCTTGTTCCAGTTTGAATGTGACAGTGAGAGCCCCACTGTGCAGCTTCGTTCAGCC
AATGGCTACTACCTATCCCAGAGGCGCCACAGGGCAGTAATGGCTGATGGGCACCCCCTGGAGT
CTGACACGTTCTTCCGAATGCACTGGAACTGTGGCAGGATCATCCTGCAGTCCTGCAGGGGGCG
CTTCCTGGGCATTGCACCCAACAGCCTGCTGATGGCCAATTCCATCCTTCCAGGCCCAAATGAG
GAATTTGGGATTTTATTTGCCAATCGCTCCTTCCTTGTATTGCGAGGTCGTTATGGCTATGTGG
GCTCCTCATCGGGCCATGACCTCATACAGTGCAACCAGGATCAGCCCGACTGCATTCATCTACT
ACCCTGCCGACCGGGTATCTACCACTTCCAGGCACAGGGGGGATCCTTCTGGTCAATAACATCC
TTTGGCACCTTTCGCCCTTGGGGCAAGTTTGCCCTCAACTTCTGTATCGAGCTTCAGGGGAGCA
ACTTACTCACTGTACTGGCCCCCAATGGCTTCTACATGCGAGCCGACCAAAGTGGCACCCTGTT
GGCAGACAGTGAAGACATTACCAGAGAGTGTATCTGGGAATTTTAGGTCAATGGGATGTCACCT
ACCAAAATCCAAATCCTCCAGGAAAAACTACTACACTAAATGGACCAGGAACCTCAGAGTCAAG
ATCCAAGAGAAGAACATCTGTTACAACTTTTCCTACCCAGTTTAGCAAAACACCTGTTTTATGC
AACAATACATCACAACAGGCCACCCCCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003806099	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000041076.1
	ENSPPAP00000041079.1

RefSeq Acc Id:

XP_003806099 ⟸ XM_003806051

- UniProtKB:

A0A2R9CGH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDETEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSLGRRQTWEILVSNEHETQAVV
RLKSVQGLYLLCECDGTVCYGRPRTSHHGCFLLRFHRNSKWTLQCLISGRYLESNGKDVFCTSH
VLSAYHMWTPRPALHVHVILYSPIHHCYARADPTMGRIWVDAAVPCLEECGFLLHFRDGCYHLE
TSTHHFLSHVDRLFSQPSSQTAFHMQVQPGGLVALCDGEGGMLYPQGTHLLLGMGCNPMRGEEW
FILQHCPTWVSLRSKTGRFISVIYDGEVRAASECLNPMSLFQFECDSESPTVQLRSANGYYLSQ
RRHRAVMADGHPLESDTFFRMHWNCGRIILQSCRGRFLGIAPNSLLMANSILPGPNEEFGILFA
NRSFLVLRGRYGYVGSSSGHDLIQCNQDQPDCIHLLPCRPGIYHFQAQGGSFWSITSFGTFRPW
GKFALNFCIELQGSNLLTVLAPNGFYMRADQSGTLLADSEDITRECIWEF

hide sequence

Ensembl Acc Id:

ENSPPAP00000041079 ⟸ ENSPPAT00000064000

Ensembl Acc Id:

ENSPPAP00000041076 ⟸ ENSPPAT00000063997

Protein Domains

Fascin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000043161	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000063997.1	UniProtKB/TrEMBL
	ENSPPAT00000064000.1	UniProtKB/TrEMBL
Gene3D-CATH	2.80.10.50	UniProtKB/TrEMBL
InterPro	Actin-crosslinking	UniProtKB/TrEMBL
	Fascin	UniProtKB/TrEMBL
	Fascin-domain	UniProtKB/TrEMBL
	Fascin_metazoans	UniProtKB/TrEMBL
KEGG Report	pps:100986467	UniProtKB/TrEMBL
NCBI Gene	FSCN3	ENTREZGENE
PANTHER	PTHR10551	UniProtKB/TrEMBL
	PTHR10551:SF1	UniProtKB/TrEMBL
Pfam	Fascin	UniProtKB/TrEMBL
PIRSF	Fascin	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50405	UniProtKB/TrEMBL
UniProt	A0A2R9CGH3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CGN8_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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