LCOR (ligand dependent nuclear receptor corepressor) - Rat Genome Database

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Gene: LCOR (ligand dependent nuclear receptor corepressor) Pan paniscus
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Symbol: LCOR
Name: ligand dependent nuclear receptor corepressor
RGD ID: 11747406
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of transcription by RNA polymerase II (ortholog); transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); prostate cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ligand-dependent corepressor; ligand-dependent nuclear receptor corepressor-like protein; LOC100978739; uncharacterized protein C10orf12
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,746,901 - 108,898,139 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,752,221 - 108,903,795 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01093,454,741 - 93,609,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,953,511 - 97,106,845 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1097,067,801 - 97,106,845 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LCOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,746,901 - 108,898,139 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,752,221 - 108,903,795 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01093,454,741 - 93,609,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,953,511 - 97,106,845 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1097,067,801 - 97,106,845 (+)Ensemblpanpan1.1panPan2
LCOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381096,832,298 - 96,995,956 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1096,832,254 - 96,995,956 (+)EnsemblGRCh38hg38GRCh38
GRCh371098,592,055 - 98,755,713 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361098,582,727 - 98,708,655 (+)NCBINCBI36Build 36hg18NCBI36
Celera1092,333,590 - 92,465,797 (+)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1092,221,267 - 92,352,266 (+)NCBIHuRef
CHM1_11098,873,752 - 99,006,489 (+)NCBICHM1_1
T2T-CHM13v2.01097,713,211 - 97,876,841 (+)NCBIT2T-CHM13v2.0
Lcor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,471,121 - 41,584,600 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,471,076 - 41,574,975 (+)EnsemblGRCm39 Ensembl
GRCm381941,482,682 - 41,596,161 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,482,637 - 41,586,536 (+)EnsemblGRCm38mm10GRCm38
MGSCv371941,624,129 - 41,634,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,602,950 - 41,613,092 (+)NCBIMGSCv36mm8
Celera1942,347,665 - 42,357,805 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.97NCBI
Lcor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,247,965 - 250,354,985 (+)NCBIGRCr8
mRatBN7.21240,298,565 - 240,405,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,298,563 - 240,402,448 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1248,441,750 - 248,548,793 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,138,875 - 255,245,940 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,791,893 - 247,898,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01260,775,091 - 260,839,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01260,789,955 - 260,809,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,732,485 - 260,830,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,187,859 - 268,287,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,702,984 - 246,800,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,818,012 - 246,915,428 (+)NCBI
Celera1236,138,607 - 236,245,268 (+)NCBICelera
Cytogenetic Map1q54NCBI
LCOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,192,587 - 10,337,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,193,748 - 10,335,626 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2810,377,753 - 10,529,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02810,514,666 - 10,667,693 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2810,462,893 - 10,659,912 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,176,823 - 10,329,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,237,535 - 10,389,797 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02810,377,331 - 10,530,360 (+)NCBIUU_Cfam_GSD_1.0
Lcor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,551,541 - 36,681,047 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366362,595,394 - 2,626,824 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366362,594,777 - 2,720,153 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100627422
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,304,048 - 108,436,982 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,304,010 - 108,443,576 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214117,940,134 - 118,079,352 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,009,449 - 90,157,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,152,909 - 90,156,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604850,898,268 - 51,059,239 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lcor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247378,369,522 - 8,446,114 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247378,302,285 - 8,456,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000027577   ⟹   ENSPPAP00000006377
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1097,067,801 - 97,106,845 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000027579   ⟹   ENSPPAP00000006379
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1097,067,801 - 97,077,164 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000027582   ⟹   ENSPPAP00000006381
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1097,067,801 - 97,074,665 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000027584   ⟹   ENSPPAP00000006383
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1097,067,801 - 97,074,665 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000027587   ⟹   ENSPPAP00000006385
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1097,067,972 - 97,103,431 (+)Ensembl
RefSeq Acc Id: XM_014346570   ⟹   XP_014202056
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,747,583 - 108,898,139 (+)NCBI
NHGRI_mPanPan110108,752,903 - 108,903,795 (+)NCBI
Mhudiblu_PPA_v01093,455,437 - 93,609,317 (+)NCBI
PanPan1.11096,953,527 - 97,106,845 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034931230   ⟹   XP_034787121
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,747,592 - 108,898,139 (+)NCBI
NHGRI_mPanPan110108,752,917 - 108,903,795 (+)NCBI
Mhudiblu_PPA_v01093,455,437 - 93,609,317 (+)NCBI
RefSeq Acc Id: XM_034931231   ⟹   XP_034787122
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,746,901 - 108,898,139 (+)NCBI
NHGRI_mPanPan110108,752,221 - 108,903,795 (+)NCBI
Mhudiblu_PPA_v01093,454,741 - 93,609,317 (+)NCBI
RefSeq Acc Id: XM_034931233   ⟹   XP_034787124
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,746,973 - 108,898,139 (+)NCBI
NHGRI_mPanPan110108,752,310 - 108,903,795 (+)NCBI
Mhudiblu_PPA_v01093,454,756 - 93,609,317 (+)NCBI
RefSeq Acc Id: XM_034931234   ⟹   XP_034787125
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,746,907 - 108,898,139 (+)NCBI
NHGRI_mPanPan110108,752,237 - 108,903,795 (+)NCBI
Mhudiblu_PPA_v01093,454,771 - 93,609,317 (+)NCBI
RefSeq Acc Id: XM_034931235   ⟹   XP_034787126
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,747,592 - 108,877,841 (+)NCBI
NHGRI_mPanPan110108,752,917 - 108,883,166 (+)NCBI
Mhudiblu_PPA_v01093,455,442 - 93,585,677 (+)NCBI
RefSeq Acc Id: XM_055093242   ⟹   XP_054949217
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,746,901 - 108,877,841 (+)NCBI
NHGRI_mPanPan110108,752,221 - 108,883,166 (+)NCBI
RefSeq Acc Id: XM_055093243   ⟹   XP_054949218
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,747,576 - 108,877,841 (+)NCBI
NHGRI_mPanPan110108,752,896 - 108,883,166 (+)NCBI
RefSeq Acc Id: XM_055093244   ⟹   XP_054949219
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,746,917 - 108,877,841 (+)NCBI
NHGRI_mPanPan110108,752,250 - 108,883,166 (+)NCBI
RefSeq Acc Id: XM_063607835   ⟹   XP_063463905
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,747,692 - 108,898,139 (+)NCBI
RefSeq Acc Id: XM_063607836   ⟹   XP_063463906
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,823,357 - 108,898,139 (+)NCBI
RefSeq Acc Id: XP_014202056   ⟸   XM_014346570
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZU29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034787122   ⟸   XM_034931231
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZU29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787124   ⟸   XM_034931233
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZU29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787125   ⟸   XM_034931234
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZU29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787121   ⟸   XM_034931230
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZU29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787126   ⟸   XM_034931235
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000006383   ⟸   ENSPPAT00000027584
RefSeq Acc Id: ENSPPAP00000006381   ⟸   ENSPPAT00000027582
RefSeq Acc Id: ENSPPAP00000006385   ⟸   ENSPPAT00000027587
RefSeq Acc Id: ENSPPAP00000006379   ⟸   ENSPPAT00000027579
RefSeq Acc Id: ENSPPAP00000006377   ⟸   ENSPPAT00000027577
RefSeq Acc Id: XP_054949217   ⟸   XM_055093242
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054949219   ⟸   XM_055093244
- Peptide Label: isoform X8
- UniProtKB: A0A2R8ZR48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054949218   ⟸   XM_055093243
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063463905   ⟸   XM_063607835
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063463906   ⟸   XM_063607836
- Peptide Label: isoform X4
Protein Domains
HTH psq-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000024948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000027577.1 UniProtKB/TrEMBL
  ENSPPAT00000027579.1 UniProtKB/TrEMBL
  ENSPPAT00000027582.1 UniProtKB/TrEMBL
  ENSPPAT00000027584.1 UniProtKB/TrEMBL
  ENSPPAT00000027587.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro DUF4553 UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  HTH_Psq UniProtKB/TrEMBL
KEGG Report pps:100978739 UniProtKB/TrEMBL
NCBI Gene LOC100978739 ENTREZGENE
PANTHER LIGAND DEPENDENT NUCLEAR RECEPTOR COREPRESSOR UniProtKB/TrEMBL
  LIGAND-DEPENDENT COREPRESSOR UniProtKB/TrEMBL
  PTHR14931 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR MLR1/2 UniProtKB/TrEMBL
Pfam DUF4553 UniProtKB/TrEMBL
  HTH_psq UniProtKB/TrEMBL
PROSITE HTH_PSQ UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A2R8ZN46_PANPA UniProtKB/TrEMBL
  A0A2R8ZN52_PANPA UniProtKB/TrEMBL
  A0A2R8ZPF9_PANPA UniProtKB/TrEMBL
  A0A2R8ZR48 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZU29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-08 LCOR  ligand dependent nuclear receptor corepressor  LOC100978739  ligand-dependent corepressor  Symbol and/or name change 5135510 APPROVED