LDHC (lactate dehydrogenase C) - Rat Genome Database

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Gene: LDHC (lactate dehydrogenase C) Pan paniscus
Analyze
Symbol: LDHC
Name: lactate dehydrogenase C
RGD ID: 11744453
Description: ENCODES a protein that exhibits catalytic activity (inferred); L-lactate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN ATP biosynthetic process (ortholog); flagellated sperm motility (ortholog); lactate biosynthetic process from pyruvate (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypertrophic cardiomyopathy 12 (ortholog); intellectual disability (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: L-lactate dehydrogenase C chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,729,119 - 20,768,321 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,689,477 - 20,728,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,450,117 - 18,489,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,132,829 - 18,172,055 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,132,829 - 18,172,055 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
motile cilium  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LDHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,729,119 - 20,768,321 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,689,477 - 20,728,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,450,117 - 18,489,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,132,829 - 18,172,055 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,132,829 - 18,172,055 (+)Ensemblpanpan1.1panPan2
LDHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,412,318 - 18,452,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,412,318 - 18,452,063 (+)EnsemblGRCh38hg38GRCh38
GRCh371118,433,865 - 18,473,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,390,429 - 18,429,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 341118,390,482 - 18,429,366NCBI
Celera1118,568,783 - 18,608,411 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,119,079 - 18,158,522 (+)NCBIHuRef
CHM1_11118,433,317 - 18,472,228 (+)NCBICHM1_1
T2T-CHM13v2.01118,510,444 - 18,550,172 (+)NCBIT2T-CHM13v2.0
Ldhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,510,687 - 46,527,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,510,627 - 46,527,566 (+)EnsemblGRCm39 Ensembl
GRCm38746,861,263 - 46,878,147 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,861,203 - 46,878,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv37754,116,633 - 54,133,512 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,729,305 - 46,746,184 (+)NCBIMGSCv36mm8
Celera742,341,209 - 42,358,089 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.6NCBI
Ldhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,522,140 - 106,539,649 (+)NCBIGRCr8
mRatBN7.2197,385,984 - 97,403,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,382,379 - 97,403,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,779,292 - 102,796,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,251,274 - 111,268,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,535,059 - 104,551,715 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,914,875 - 102,931,843 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,915,191 - 102,931,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,989,930 - 104,006,583 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,418,622 - 97,435,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,496,732 - 97,513,382 (+)NCBI
Celera191,633,230 - 91,649,970 (+)NCBICelera
Cytogenetic Map1q22NCBI
LOC102020557
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,110,120 - 33,138,756 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,109,535 - 33,138,756 (+)NCBIChiLan1.0ChiLan1.0
LDHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,844,644 - 40,890,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,844,662 - 40,890,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,324,373 - 40,369,674 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,966,636 - 42,012,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,966,655 - 42,012,233 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,960,921 - 41,006,005 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,149,688 - 41,192,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,527,202 - 41,570,252 (+)NCBIUU_Cfam_GSD_1.0
LOC101970352
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,793,662 - 44,828,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528827,758 - 862,393 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936528827,322 - 862,832 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,748,863 - 40,809,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,748,567 - 40,810,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,655,396 - 43,730,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,480,425 - 46,528,307 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038143,836,012 - 143,883,405 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715932
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,886,618 - 9,921,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,882,494 - 9,943,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052993   ⟹   ENSPPAP00000030135
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,132,829 - 18,172,055 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053009   ⟹   ENSPPAP00000030151
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,132,867 - 18,172,055 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053024   ⟹   ENSPPAP00000030166
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,133,280 - 18,171,931 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053034   ⟹   ENSPPAP00000030175
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,133,280 - 18,171,852 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053036   ⟹   ENSPPAP00000030177
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,133,280 - 18,171,852 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053041   ⟹   ENSPPAP00000030182
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,133,280 - 18,171,782 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053044   ⟹   ENSPPAP00000030185
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,171,594 - 18,171,931 (+)Ensembl
RefSeq Acc Id: XM_003818235   ⟹   XP_003818283
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,729,119 - 20,768,321 (+)NCBI
NHGRI_mPanPan11120,689,477 - 20,728,675 (+)NCBI
Mhudiblu_PPA_v01118,450,117 - 18,489,321 (+)NCBI
PanPan1.11118,132,829 - 18,172,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003818236   ⟹   XP_003818284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,729,138 - 20,768,321 (+)NCBI
NHGRI_mPanPan11120,689,500 - 20,728,675 (+)NCBI
Mhudiblu_PPA_v01118,450,141 - 18,489,321 (+)NCBI
PanPan1.11118,132,865 - 18,172,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971506   ⟹   XP_008969754
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,729,119 - 20,768,321 (+)NCBI
NHGRI_mPanPan11120,689,477 - 20,728,675 (+)NCBI
Mhudiblu_PPA_v01118,450,117 - 18,489,321 (+)NCBI
PanPan1.11118,132,829 - 18,172,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063608124   ⟹   XP_063464194
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,729,136 - 20,768,321 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003818283   ⟸   XM_003818235
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BUA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008969754   ⟸   XM_008971506
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BKE8 (UniProtKB/TrEMBL),   A0A2R9BKJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003818284   ⟸   XM_003818236
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BUA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000030151   ⟸   ENSPPAT00000053009
RefSeq Acc Id: ENSPPAP00000030166   ⟸   ENSPPAT00000053024
RefSeq Acc Id: ENSPPAP00000030177   ⟸   ENSPPAT00000053036
RefSeq Acc Id: ENSPPAP00000030175   ⟸   ENSPPAT00000053034
RefSeq Acc Id: ENSPPAP00000030182   ⟸   ENSPPAT00000053041
RefSeq Acc Id: ENSPPAP00000030185   ⟸   ENSPPAT00000053044
RefSeq Acc Id: ENSPPAP00000030135   ⟸   ENSPPAT00000052993
RefSeq Acc Id: XP_063464194   ⟸   XM_063608124
- Peptide Label: isoform X2
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038065 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052993.1 UniProtKB/TrEMBL
  ENSPPAT00000053009.1 UniProtKB/TrEMBL
  ENSPPAT00000053024.1 UniProtKB/TrEMBL
  ENSPPAT00000053034.1 UniProtKB/TrEMBL
  ENSPPAT00000053036.1 UniProtKB/TrEMBL
  ENSPPAT00000053041.1 UniProtKB/TrEMBL
  ENSPPAT00000053044.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/TrEMBL
  L-lactate_DH UniProtKB/TrEMBL
  L-lactate_DH_AS UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100988810 UniProtKB/TrEMBL
NCBI Gene LDHC ENTREZGENE
PANTHER L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) UniProtKB/TrEMBL
  L-LACTATE DEHYDROGENASE C CHAIN UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/TrEMBL
PIRSF Lac_mal_DH UniProtKB/TrEMBL
PRINTS LLDHDRGNASE UniProtKB/TrEMBL
PROSITE L_LDH UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF56327 UniProtKB/TrEMBL
UniProt A0A2R9BKE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKK6_PANPA UniProtKB/TrEMBL
  A0A2R9BP12_PANPA UniProtKB/TrEMBL
  A0A2R9BP17_PANPA UniProtKB/TrEMBL
  A0A2R9BUA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BUB9_PANPA UniProtKB/TrEMBL