PLEKHO2 (pleckstrin homology domain containing O2) - Rat Genome Database

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Gene: PLEKHO2 (pleckstrin homology domain containing O2) Pan paniscus
Analyze
Symbol: PLEKHO2
Name: pleckstrin homology domain containing O2
RGD ID: 11743812
Description: INVOLVED IN macrophage apoptotic process (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family O member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21654,088,499 - 54,114,723 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11558,259,943 - 58,286,096 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01543,782,812 - 43,808,969 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11562,052,563 - 62,093,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1562,052,563 - 62,093,865 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PLEKHO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21654,088,499 - 54,114,723 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11558,259,943 - 58,286,096 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01543,782,812 - 43,808,969 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11562,052,563 - 62,093,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1562,052,563 - 62,093,865 (+)Ensemblpanpan1.1panPan2
PLEKHO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,841,915 - 64,868,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1564,841,883 - 64,868,002 (+)EnsemblGRCh38hg38GRCh38
GRCh371565,134,114 - 65,160,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,921,186 - 62,947,254 (+)NCBINCBI36Build 36hg18NCBI36
Celera1542,012,800 - 42,038,917 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,959,809 - 41,985,900 (+)NCBIHuRef
CHM1_11565,253,907 - 65,280,023 (+)NCBICHM1_1
T2T-CHM13v2.01562,651,199 - 62,677,284 (+)NCBIT2T-CHM13v2.0
Plekho2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39965,459,859 - 65,487,369 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl965,459,980 - 65,487,322 (-)EnsemblGRCm39 Ensembl
GRCm38965,552,577 - 65,580,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl965,552,698 - 65,580,040 (-)EnsemblGRCm38mm10GRCm38
MGSCv37965,402,191 - 65,427,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36965,352,390 - 65,378,046 (-)NCBIMGSCv36mm8
Celera962,784,726 - 62,810,343 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.38NCBI
Plekho2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8874,973,578 - 75,000,532 (-)NCBIGRCr8
mRatBN7.2866,079,106 - 66,105,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,078,448 - 66,105,266 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0871,092,766 - 71,118,966 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,094,090 - 71,118,927 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0870,781,037 - 70,804,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4869,810,804 - 69,837,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1869,829,857 - 69,850,336 (-)NCBI
Celera865,475,229 - 65,498,713 (-)NCBICelera
Cytogenetic Map8q24NCBI
Plekho2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545010,692,305 - 10,714,031 (-)NCBIChiLan1.0ChiLan1.0
PLEKHO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13029,242,306 - 29,264,632 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3029,242,206 - 29,262,716 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3029,170,786 - 29,193,082 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03029,428,973 - 29,451,281 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3029,428,983 - 29,451,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13029,362,366 - 29,384,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03029,424,265 - 29,446,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03029,664,775 - 29,687,120 (+)NCBIUU_Cfam_GSD_1.0
Plekho2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640107,336,039 - 107,370,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647125,190,570 - 25,207,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647125,184,128 - 25,218,035 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,186,288 - 107,218,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,186,284 - 107,209,226 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,016,229 - 118,027,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12618,711,745 - 18,737,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2618,711,757 - 18,737,736 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048122,692,772 - 122,719,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekho2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247817,791,398 - 7,814,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247817,792,419 - 7,814,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034938936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000023890   ⟹   ENSPPAP00000005236
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1562,052,563 - 62,093,865 (+)Ensembl
RefSeq Acc Id: XM_034938936   ⟹   XP_034794827
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21654,088,499 - 54,114,723 (+)NCBI
NHGRI_mPanPan11558,259,943 - 58,286,096 (+)NCBI
Mhudiblu_PPA_v01543,782,812 - 43,808,969 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034794827 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000005236.1
RefSeq Acc Id: XP_034794827   ⟸   XM_034938936
- UniProtKB: A0A2R8ZQX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000005236   ⟸   ENSPPAT00000023890
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000021793 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000023890.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PKHO1/2 UniProtKB/TrEMBL
NCBI Gene PLEKHO2 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 2 UniProtKB/TrEMBL
  PTHR15871 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A2R8ZQX4 ENTREZGENE, UniProtKB/TrEMBL