HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1) Pan paniscus
Analyze
Symbol: HACE1
Name: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
RGD ID: 11743082
Description: ENCODES a protein that exhibits small GTPase binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN Golgi organization (inferred); membrane fusion (inferred); protein K48-linked ubiquitination (inferred); ASSOCIATED WITH Developmental Disabilities (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi cisterna membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase HACE1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06102,541,992 - 102,674,281 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16106,419,867 - 106,551,004 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,419,867 - 106,551,007 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HACE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06102,541,992 - 102,674,281 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16106,419,867 - 106,551,004 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,419,867 - 106,551,007 (-)Ensemblpanpan1.1panPan2
HACE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386104,728,094 - 104,859,919 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6104,728,094 - 104,859,919 (-)EnsemblGRCh38hg38GRCh38
GRCh376105,175,969 - 105,307,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,282,661 - 105,414,487 (-)NCBINCBI36Build 36hg18NCBI36
Celera6105,798,434 - 105,930,284 (-)NCBICelera
Cytogenetic Map6q16.3NCBI
HuRef6102,619,748 - 102,751,184 (-)NCBIHuRef
CHM1_16105,437,913 - 105,569,648 (-)NCBICHM1_1
T2T-CHM13v2.06105,904,367 - 106,035,941 (-)NCBIT2T-CHM13v2.0
Hace1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391045,453,911 - 45,588,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1045,453,925 - 45,588,441 (+)EnsemblGRCm39 Ensembl
GRCm381045,577,814 - 45,712,345 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,577,829 - 45,712,345 (+)EnsemblGRCm38mm10GRCm38
MGSCv371045,297,635 - 45,432,151 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361045,266,304 - 45,400,659 (+)NCBIMGSCv36mm8
Celera1046,446,600 - 46,579,346 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.65NCBI
Hace1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82050,618,004 - 50,733,460 (+)NCBIGRCr8
mRatBN7.22049,035,312 - 49,151,103 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2049,035,648 - 49,151,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2050,772,071 - 50,880,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02050,421,828 - 50,529,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02051,106,137 - 51,214,330 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02050,652,489 - 50,783,937 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,652,745 - 50,783,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,261,033 - 52,394,868 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,856,040 - 49,973,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12049,865,875 - 50,001,077 (+)NCBI
Celera2050,882,914 - 50,991,947 (-)NCBICelera
Cytogenetic Map20q13NCBI
Hace1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541130,178,297 - 30,261,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541130,178,297 - 30,260,627 (-)NCBIChiLan1.0ChiLan1.0
HACE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,231,642 - 62,337,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,227,078 - 62,337,183 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1262,019,271 - 62,126,625 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01263,079,955 - 63,187,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1263,080,915 - 63,187,586 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11262,436,034 - 62,543,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01262,277,683 - 62,385,051 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01262,555,861 - 62,663,750 (-)NCBIUU_Cfam_GSD_1.0
Hace1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,225,086 - 97,307,884 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,499,634 - 1,582,759 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365641,499,918 - 1,582,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HACE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl170,993,342 - 71,105,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1170,994,033 - 71,104,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,233,231 - 80,376,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HACE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,932,866 - 69,059,126 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,932,824 - 69,061,053 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604041,280,266 - 41,406,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003824349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024929281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057302571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004672101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000063889   ⟹   ENSPPAP00000040968
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6106,419,867 - 106,551,007 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063899   ⟹   ENSPPAP00000040978
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6106,421,435 - 106,550,691 (-)Ensembl
RefSeq Acc Id: XM_003824349   ⟹   XP_003824397
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,674,281 (-)NCBI
PanPan1.16106,419,867 - 106,551,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034962607   ⟹   XP_034818498
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,674,250 (-)NCBI
RefSeq Acc Id: XM_034962608   ⟹   XP_034818499
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,879,525 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,765,998 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,673,893 (-)NCBI
RefSeq Acc Id: XM_034962609   ⟹   XP_034818500
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,674,250 (-)NCBI
RefSeq Acc Id: XM_034962610   ⟹   XP_034818501
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,880,278 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,766,751 (-)NCBI
Mhudiblu_PPA_v06102,542,356 - 102,674,281 (-)NCBI
RefSeq Acc Id: XM_034962613   ⟹   XP_034818504
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,869,192 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,755,629 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,663,563 (-)NCBI
RefSeq Acc Id: XM_034962614   ⟹   XP_034818505
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,869,151 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,755,588 (-)NCBI
Mhudiblu_PPA_v06102,541,992 - 102,663,523 (-)NCBI
RefSeq Acc Id: XM_055113988   ⟹   XP_054969963
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,869,151 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,755,588 (-)NCBI
RefSeq Acc Id: XM_057302571   ⟹   XP_057158554
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,747,626 - 124,869,192 (-)NCBI
NHGRI_mPanPan16122,634,129 - 122,755,629 (-)NCBI
RefSeq Acc Id: XR_004672101
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25124,764,050 - 124,880,278 (-)NCBI
NHGRI_mPanPan16122,650,537 - 122,766,751 (-)NCBI
Mhudiblu_PPA_v06102,558,423 - 102,674,253 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003824397   ⟸   XM_003824349
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CIW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034818500   ⟸   XM_034962609
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034818498   ⟸   XM_034962607
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034818499   ⟸   XM_034962608
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034818504   ⟸   XM_034962613
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034818505   ⟸   XM_034962614
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034818501   ⟸   XM_034962610
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000040968   ⟸   ENSPPAT00000063889
RefSeq Acc Id: ENSPPAP00000040978   ⟸   ENSPPAT00000063899
RefSeq Acc Id: XP_054969963   ⟸   XM_055113988
- Peptide Label: isoform X8
RefSeq Acc Id: XP_057158554   ⟸   XM_057302571
- Peptide Label: isoform X7
Protein Domains
HECT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063889.1 UniProtKB/TrEMBL
  ENSPPAT00000063899.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
KEGG Report pps:100982583 UniProtKB/TrEMBL
NCBI Gene HACE1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HACE1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  HECTc UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A2R9CIW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CIX6_PANPA UniProtKB/TrEMBL