MBD5 (methyl-CpG binding domain protein 5) - Rat Genome Database

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Gene: MBD5 (methyl-CpG binding domain protein 5) Pan paniscus
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Symbol: MBD5
Name: methyl-CpG binding domain protein 5
RGD ID: 11742205
Description: ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN glucose homeostasis (ortholog); nervous system development (ortholog); positive regulation of growth hormone receptor signaling pathway (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN chromocenter (inferred); midbody (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyl-CpG-binding domain protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,347,218 - 11,842,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,380,363 - 152,874,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,754,368 - 152,874,042 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromocenter  (IEA)
midbody  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MBD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,347,218 - 11,842,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,380,363 - 152,874,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,754,368 - 152,874,042 (+)Ensemblpanpan1.1panPan2
MBD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,020,927 - 148,516,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,021,011 - 148,516,971 (+)EnsemblGRCh38hg38GRCh38
GRCh372148,778,580 - 149,274,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,932,508 - 148,987,516 (+)NCBINCBI36Build 36hg18NCBI36
Build 342149,049,769 - 149,104,774NCBI
Celera2142,492,728 - 142,985,183 (+)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,776,638 - 141,269,422 (+)NCBIHuRef
CHM1_12148,784,226 - 149,276,488 (+)NCBICHM1_1
T2T-CHM13v2.02148,471,381 - 148,967,332 (+)NCBIT2T-CHM13v2.0
Mbd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,839,511 - 49,209,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,839,520 - 49,215,417 (+)EnsemblGRCm39 Ensembl
GRCm38248,949,499 - 49,319,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,949,508 - 49,325,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,805,028 - 49,172,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,064,365 - 49,139,005 (+)NCBIMGSCv36mm8
Celera250,621,661 - 50,990,507 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.43NCBI
Mbd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,742,458 - 54,147,970 (+)NCBIGRCr8
mRatBN7.2333,588,854 - 33,738,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,333,554 - 33,730,156 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0333,364,812 - 33,504,144 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,440,191 - 33,504,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,600,038 - 38,663,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera331,856,644 - 31,921,520 (+)NCBICelera
Cytogenetic Map3q12NCBI
Mbd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,270,407 - 14,413,597 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544014,267,802 - 14,412,949 (+)NCBIChiLan1.0ChiLan1.0
MBD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,815,388 - 50,250,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,186,364 - 50,247,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1950,145,330 - 50,371,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,494,265 - 51,720,677 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,494,282 - 51,728,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,139,740 - 50,365,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,274,378 - 50,500,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,671,900 - 51,898,368 (+)NCBIUU_Cfam_GSD_1.0
Mbd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,486,058 - 112,872,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,744,814 - 28,802,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,748,499 - 28,889,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,659,012 - 3,725,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,649,859 - 4,096,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,337,836 - 3,346,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,401,903 - 33,907,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,743,166 - 33,904,508 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,632,515 - 166,137,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,105,616 - 1,162,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248661,003,279 - 1,162,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000051070   ⟹   ENSPPAP00000028224
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B152,754,368 - 152,873,506 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051075   ⟹   ENSPPAP00000028229
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B152,818,704 - 152,874,042 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051079   ⟹   ENSPPAP00000028233
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B152,818,704 - 152,866,392 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051087   ⟹   ENSPPAP00000028241
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B152,819,262 - 152,863,359 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000051093   ⟹   ENSPPAP00000028247
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B152,819,262 - 152,820,726 (+)Ensembl
RefSeq Acc Id: XM_008969801   ⟹   XP_008968049
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBI
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBI
Mhudiblu_PPA_v02B11,347,218 - 11,842,451 (-)NCBI
PanPan1.12B152,380,371 - 152,874,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034954025   ⟹   XP_034809916
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBI
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBI
Mhudiblu_PPA_v02B11,347,218 - 11,842,644 (-)NCBI
RefSeq Acc Id: XM_063595136   ⟹   XP_063451206
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBI
RefSeq Acc Id: XM_063595137   ⟹   XP_063451207
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBI
RefSeq Acc Id: XM_063595138   ⟹   XP_063451208
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,529 (-)NCBI
RefSeq Acc Id: XM_063595139   ⟹   XP_063451209
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBI
RefSeq Acc Id: XM_063595140   ⟹   XP_063451210
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21326,413,395 - 26,748,940 (-)NCBI
RefSeq Acc Id: XP_008968049   ⟸   XM_008969801
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BEZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034809916   ⟸   XM_034954025
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BEZ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000028229   ⟸   ENSPPAT00000051075
RefSeq Acc Id: ENSPPAP00000028224   ⟸   ENSPPAT00000051070
RefSeq Acc Id: ENSPPAP00000028233   ⟸   ENSPPAT00000051079
RefSeq Acc Id: ENSPPAP00000028241   ⟸   ENSPPAT00000051087
RefSeq Acc Id: ENSPPAP00000028247   ⟸   ENSPPAT00000051093
RefSeq Acc Id: XP_063451209   ⟸   XM_063595139
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063451206   ⟸   XM_063595136
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063451207   ⟸   XM_063595137
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063451208   ⟸   XM_063595138
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063451210   ⟸   XM_063595140
- Peptide Label: isoform X4
Protein Domains
MBD   PWWP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037170 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051070.1 UniProtKB/TrEMBL
  ENSPPAT00000051075.1 UniProtKB/TrEMBL
  ENSPPAT00000051079.1 UniProtKB/TrEMBL
  ENSPPAT00000051087.1 UniProtKB/TrEMBL
  ENSPPAT00000051093.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
InterPro DNA-bd_dom_sf UniProtKB/TrEMBL
  MBD5/MBD6 UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
  PWWP_dom UniProtKB/TrEMBL
KEGG Report pps:100977454 UniProtKB/TrEMBL
NCBI Gene MBD5 ENTREZGENE
PANTHER METHYL-CPG-BINDING DOMAIN PROTEIN 5 UniProtKB/TrEMBL
  PTHR16112 UniProtKB/TrEMBL
PROSITE MBD UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A2R9BEZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BG58_PANPA UniProtKB/TrEMBL
  A0A2R9BIW9_PANPA UniProtKB/TrEMBL
  A0A2R9BNM3_PANPA UniProtKB/TrEMBL