SERGEF (secretion regulating guanine nucleotide exchange factor) - Rat Genome Database

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Gene: SERGEF (secretion regulating guanine nucleotide exchange factor) Pan paniscus
Analyze
Symbol: SERGEF
Name: secretion regulating guanine nucleotide exchange factor
RGD ID: 11727899
Description: INVOLVED IN negative regulation of protein secretion (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: secretion-regulating guanine nucleotide exchange factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,120,130 - 20,345,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,080,591 - 20,305,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,841,133 - 18,066,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,524,117 - 17,748,898 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERGEF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,120,130 - 20,345,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,080,591 - 20,305,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,841,133 - 18,066,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,524,117 - 17,748,898 (-)NCBIpanpan1.1PanPan1.1panPan2
SERGEF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,788,048 - 18,013,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,788,048 - 18,013,047 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,809,595 - 18,034,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,766,171 - 17,991,213 (-)NCBINCBI36Build 36hg18NCBI36
Celera1117,942,106 - 18,166,667 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,492,854 - 17,717,359 (-)NCBIHuRef
CHM1_11117,809,310 - 18,034,174 (-)NCBICHM1_1
T2T-CHM13v2.01117,885,746 - 18,110,678 (-)NCBIT2T-CHM13v2.0
Sergef
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,092,583 - 46,289,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,092,578 - 46,289,231 (-)EnsemblGRCm39 Ensembl
GRCm38746,443,159 - 46,642,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,443,154 - 46,639,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,698,529 - 53,895,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,311,215 - 46,507,832 (-)NCBIMGSCv36mm8
Celera741,916,678 - 42,113,981 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.2NCBI
Sergef
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,085,950 - 106,288,815 (-)NCBIGRCr8
mRatBN7.2196,949,660 - 97,152,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,949,661 - 97,152,496 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,335,680 - 102,538,499 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,807,664 - 111,010,491 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,098,054 - 104,300,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,461,327 - 102,664,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,461,329 - 102,664,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,546,392 - 103,741,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,974,978 - 97,181,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera191,197,981 - 91,399,879 (-)NCBICelera
Cytogenetic Map1q22NCBI
Sergef
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,584,839 - 32,796,725 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,579,419 - 32,796,714 (-)NCBIChiLan1.0ChiLan1.0
SERGEF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,321,334 - 40,540,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,321,371 - 40,540,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,820,922 - 40,040,358 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,425,810 - 41,645,276 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,425,821 - 41,645,241 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,438,547 - 40,657,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,646,432 - 40,865,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,984,861 - 41,204,276 (-)NCBIUU_Cfam_GSD_1.0
Sergef
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,088,583 - 45,318,665 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,122,570 - 1,347,150 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,122,460 - 1,351,621 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERGEF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,114,178 - 41,356,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,114,174 - 41,356,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,178,020 - 44,417,161 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERGEF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,956,423 - 47,185,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038144,345,088 - 144,577,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sergef
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,399,174 - 9,624,590 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,399,166 - 9,624,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008971489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014346744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014346745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024930818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024930819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024930820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024930821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034932262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055094214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055094215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055094216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063608116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001338602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004665020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008620158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_008971489   ⟹   XP_008969737
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,217 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,080,678 - 20,305,557 (-)NCBI
Mhudiblu_PPA_v01117,841,220 - 18,066,211 (-)NCBI
PanPan1.11117,524,204 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346744   ⟹   XP_014202230
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,176,324 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,136,785 - 20,305,599 (-)NCBI
Mhudiblu_PPA_v01117,897,308 - 18,066,161 (-)NCBI
PanPan1.11117,580,152 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346745   ⟹   XP_014202231
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,209,908 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,170,357 - 20,305,590 (-)NCBI
Mhudiblu_PPA_v01117,930,893 - 18,066,161 (-)NCBI
PanPan1.11117,613,708 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930818   ⟹   XP_024786586
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,080,591 - 20,305,570 (-)NCBI
Mhudiblu_PPA_v01117,841,133 - 18,066,160 (-)NCBI
PanPan1.11117,524,117 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930819   ⟹   XP_024786587
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,239 (-)NCBI
NHGRI_mPanPan11120,080,591 - 20,305,588 (-)NCBI
Mhudiblu_PPA_v01117,841,133 - 18,066,160 (-)NCBI
PanPan1.11117,524,117 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930820   ⟹   XP_024786588
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,188 (-)NCBI
NHGRI_mPanPan11120,080,591 - 20,305,599 (-)NCBI
Mhudiblu_PPA_v01117,841,133 - 18,066,161 (-)NCBI
PanPan1.11117,524,117 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930821   ⟹   XP_024786589
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,344,996 (-)NCBI
NHGRI_mPanPan11120,080,591 - 20,305,307 (-)NCBI
Mhudiblu_PPA_v01117,841,133 - 18,065,911 (-)NCBI
PanPan1.11117,524,117 - 17,748,694 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034932255   ⟹   XP_034788146
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,190 (-)NCBI
NHGRI_mPanPan11120,080,591 - 20,305,600 (-)NCBI
Mhudiblu_PPA_v01117,841,133 - 18,066,161 (-)NCBI
RefSeq Acc Id: XM_034932256   ⟹   XP_034788147
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,217 - 20,345,147 (-)NCBI
NHGRI_mPanPan11120,080,678 - 20,305,557 (-)NCBI
Mhudiblu_PPA_v01117,841,220 - 18,066,159 (-)NCBI
RefSeq Acc Id: XM_055094214   ⟹   XP_054950189
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,449 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,080,910 - 20,305,600 (-)NCBI
RefSeq Acc Id: XM_055094215   ⟹   XP_054950190
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,176,324 - 20,345,198 (-)NCBI
NHGRI_mPanPan11120,136,785 - 20,305,607 (-)NCBI
RefSeq Acc Id: XM_055094216   ⟹   XP_054950191
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,209,908 - 20,345,198 (-)NCBI
NHGRI_mPanPan11120,170,357 - 20,305,607 (-)NCBI
RefSeq Acc Id: XM_063608111   ⟹   XP_063464181
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,217 - 20,345,147 (-)NCBI
RefSeq Acc Id: XM_063608112   ⟹   XP_063464182
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,344,794 (-)NCBI
RefSeq Acc Id: XM_063608113   ⟹   XP_063464183
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,003 (-)NCBI
RefSeq Acc Id: XM_063608114   ⟹   XP_063464184
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,345,003 (-)NCBI
RefSeq Acc Id: XM_063608115   ⟹   XP_063464185
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,344,794 (-)NCBI
RefSeq Acc Id: XM_063608116   ⟹   XP_063464186
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,120,130 - 20,344,794 (-)NCBI
RefSeq Acc Id: XR_001338602
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,176,324 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,136,785 - 20,305,599 (-)NCBI
Mhudiblu_PPA_v01117,897,308 - 18,066,161 (-)NCBI
PanPan1.11117,580,928 - 17,748,898 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004665020
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,176,324 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,136,785 - 20,305,599 (-)NCBI
Mhudiblu_PPA_v01117,897,308 - 18,066,161 (-)NCBI
RefSeq Acc Id: XR_008620158
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2920,210,270 - 20,345,235 (-)NCBI
NHGRI_mPanPan11120,170,719 - 20,305,596 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008969737   ⟸   XM_008971489
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_014202230   ⟸   XM_014346744
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_014202231   ⟸   XM_014346745
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_024786587   ⟸   XM_024930819
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024786588   ⟸   XM_024930820
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024786586   ⟸   XM_024930818
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024786589   ⟸   XM_024930821
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_034788146   ⟸   XM_034932255
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034788147   ⟸   XM_034932256
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054950189   ⟸   XM_055094214
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054950190   ⟸   XM_055094215
- Peptide Label: isoform X12
RefSeq Acc Id: XP_054950191   ⟸   XM_055094216
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063464184   ⟸   XM_063608114
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063464183   ⟸   XM_063608113
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063464186   ⟸   XM_063608116
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063464185   ⟸   XM_063608115
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063464182   ⟸   XM_063608112
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063464181   ⟸   XM_063608111
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041411 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000060213.1 UniProtKB/TrEMBL
  ENSPPAT00000060216.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
InterPro RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
NCBI Gene SERGEF ENTREZGENE
PANTHER RCC1 REPEAT-CONTAINING PROTEIN C10F6.04 UniProtKB/TrEMBL
  REGULATOR OF CHROMOSOME CONDENSATION UniProtKB/TrEMBL
Pfam RCC1 UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/TrEMBL
UniProt A0A2R9C5W9_PANPA UniProtKB/TrEMBL
  A0A2R9C8P2_PANPA UniProtKB/TrEMBL