PDE6H (phosphodiesterase 6H) - Rat Genome Database

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Gene: PDE6H (phosphodiesterase 6H) Pan paniscus
Analyze
Symbol: PDE6H
Name: phosphodiesterase 6H
RGD ID: 11723903
Description: ENCODES a protein that exhibits 3',5'-cyclic-GMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); cGMP binding (inferred); INVOLVED IN positive regulation of epidermal growth factor receptor signaling pathway (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); positive regulation of MAPK cascade (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 6 (ortholog); color blindness (ortholog); cone-rod dystrophy 14 (ortholog); FOUND IN photoreceptor outer segment membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,254,398 - 20,430,243 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,285,815 - 20,427,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,890,192 - 14,984,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,372,413 - 15,381,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,372,413 - 15,381,249 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDE6H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,254,398 - 20,430,243 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,285,815 - 20,427,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,890,192 - 14,984,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,372,413 - 15,381,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,372,413 - 15,381,249 (+)Ensemblpanpan1.1panPan2
PDE6H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,973,042 - 14,981,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,973,042 - 14,981,865 (+)EnsemblGRCh38hg38GRCh38
GRCh371215,125,976 - 15,134,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,017,245 - 15,026,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 341215,017,244 - 15,026,066NCBI
Celera1220,270,954 - 20,279,795 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,895,337 - 14,904,178 (+)NCBIHuRef
CHM1_11215,092,057 - 15,100,898 (+)NCBICHM1_1
T2T-CHM13v2.01214,850,375 - 14,859,197 (+)NCBIT2T-CHM13v2.0
Pde6h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,929,216 - 136,940,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,900,830 - 136,945,863 (+)EnsemblGRCm39 Ensembl
GRCm386136,952,218 - 136,963,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,923,832 - 136,968,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv376136,903,044 - 136,912,004 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,918,719 - 136,927,678 (+)NCBIMGSCv36mm8
Celera6139,997,648 - 140,006,582 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.72NCBI
Pde6h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,588,896 - 171,604,142 (+)NCBIGRCr8
mRatBN7.24169,857,793 - 169,872,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,857,812 - 169,872,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,164,525 - 176,169,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,944,657 - 171,949,411 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,570,202 - 170,574,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,947,723 - 170,963,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,958,196 - 170,963,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,204,371 - 235,219,664 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,009,860 - 174,014,405 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,254,983 - 174,259,529 (+)NCBI
Celera4158,449,142 - 158,453,876 (+)NCBICelera
Cytogenetic Map4q43NCBI
Pde6h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,703,378 - 11,712,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541311,654,252 - 11,711,799 (+)NCBIChiLan1.0ChiLan1.0
PDE6H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,640,731 - 31,664,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,640,737 - 31,664,401 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,784,654 - 14,808,356 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02731,947,405 - 31,970,923 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,947,411 - 31,970,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,836,788 - 31,860,326 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,795,045 - 31,818,763 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,516,903 - 14,540,640 (+)NCBIUU_Cfam_GSD_1.0
Pde6h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,778,204 - 92,786,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,506,585 - 2,514,157 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,505,755 - 2,514,103 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE6H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,556,149 - 57,594,423 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,555,448 - 57,582,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,944,506 - 60,978,007 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE6H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,869,864 - 14,880,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,870,498 - 14,880,324 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,430,389 - 20,439,864 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde6h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475223,051,752 - 23,055,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475223,051,486 - 23,055,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052930   ⟹   ENSPPAP00000030073
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1215,372,413 - 15,381,249 (+)Ensembl
RefSeq Acc Id: XM_055095433   ⟹   XP_054951408
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21020,254,398 - 20,430,243 (+)NCBI
NHGRI_mPanPan11220,285,815 - 20,427,004 (+)NCBI
RefSeq Acc Id: XM_063593010   ⟹   XP_063449080
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21020,255,154 - 20,430,243 (+)NCBI
RefSeq Acc Id: XM_063593011   ⟹   XP_063449081
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21020,255,166 - 20,430,243 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054951408 (Get FASTA)   NCBI Sequence Viewer  
  XP_063449080 (Get FASTA)   NCBI Sequence Viewer  
  XP_063449081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000030073.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000030073   ⟸   ENSPPAT00000052930
RefSeq Acc Id: XP_054951408   ⟸   XM_055095433
- UniProtKB: A0A2R9BKZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063449080   ⟸   XM_063593010
- UniProtKB: A0A2R9BKZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063449081   ⟸   XM_063593011
- UniProtKB: A0A2R9BKZ5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038039 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052930.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1120.10 UniProtKB/TrEMBL
InterPro PDE6_gamma UniProtKB/TrEMBL
  PDE6_gamma_sf UniProtKB/TrEMBL
KEGG Report pps:100979826 UniProtKB/TrEMBL
NCBI Gene PDE6H ENTREZGENE
PANTHER PTHR12122 UniProtKB/TrEMBL
  RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA UniProtKB/TrEMBL
Pfam PDE6_gamma UniProtKB/TrEMBL
PIRSF 35-cGMP_Pdiase_g UniProtKB/TrEMBL
UniProt A0A2R9BKZ5 ENTREZGENE, UniProtKB/TrEMBL