SPTLC2 (serine palmitoyltransferase long chain base subunit 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SPTLC2 (serine palmitoyltransferase long chain base subunit 2) Pan paniscus
Analyze
Symbol: SPTLC2
Name: serine palmitoyltransferase long chain base subunit 2
RGD ID: 11718225
Description: ENCODES a protein that exhibits serine C-palmitoyltransferase activity (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); positive regulation of lipophagy (ortholog); sphinganine biosynthetic process (ortholog); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); COVID-19 (ortholog); hereditary sensory and autonomic neuropathy type 1C (ortholog); FOUND IN serine C-palmitoyltransferase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine palmitoyltransferase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11477,266,545 - 77,370,663 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,266,545 - 77,370,663 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01458,066,123 - 58,170,472 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SPTLC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11477,266,545 - 77,370,663 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,266,545 - 77,370,663 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01458,066,123 - 58,170,472 (-)NCBIMhudiblu_PPA_v0panPan3
SPTLC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1477,505,997 - 77,616,637 (-)EnsemblGRCh38hg38GRCh38
GRCh381477,505,997 - 77,616,663 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371477,972,340 - 78,082,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361477,043,023 - 77,152,863 (-)NCBINCBI36hg18NCBI36
Build 341477,043,024 - 77,152,863NCBI
Celera1458,011,851 - 58,121,636 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1458,138,337 - 58,249,054 (-)NCBIHuRef
CHM1_11477,911,814 - 78,022,586 (-)NCBICHM1_1
Sptlc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,351,832 - 87,435,129 (-)NCBIGRCm39mm39
GRCm39 Ensembl1287,351,832 - 87,435,129 (-)Ensembl
GRCm381287,305,058 - 87,388,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,305,058 - 87,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,648,839 - 88,729,180 (-)NCBIGRCm37mm9NCBIm37
MGSCv361288,196,992 - 88,277,333 (-)NCBImm8
Celera1288,772,417 - 88,852,773 (-)NCBICelera
Cytogenetic Map12D2NCBI
Sptlc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26106,948,681 - 107,031,584 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl6106,950,949 - 107,031,542 (-)Ensembl
Rnor_6.06111,334,408 - 111,417,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,339,136 - 111,417,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,616,251 - 120,699,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,546,037 - 111,622,959 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16111,245,978 - 111,626,585 (-)NCBI
Celera6104,771,427 - 104,849,755 (-)NCBICelera
Cytogenetic Map6q31NCBI
Sptlc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,385,431 - 1,491,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,385,431 - 1,491,534 (-)NCBIChiLan1.0ChiLan1.0
SPTLC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,291,797 - 50,401,202 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,271,010 - 50,401,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,979,477 - 50,088,850 (-)NCBI
ROS_Cfam_1.0850,525,698 - 50,635,391 (-)NCBI
ROS_Cfam_1.0 Ensembl850,530,838 - 50,635,427 (-)Ensembl
UMICH_Zoey_3.1850,188,135 - 50,297,514 (-)NCBI
UNSW_CanFamBas_1.0850,211,301 - 50,320,641 (-)NCBI
UU_Cfam_GSD_1.0850,609,185 - 50,719,362 (-)NCBI
LOC101967158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,664,744 - 25,778,794 (+)NCBI
SpeTri2.0NW_0049364886,313,189 - 6,404,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTLC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,544,478 - 100,638,907 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,545,360 - 100,638,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,672,604 - 106,730,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPTLC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,769,072 - 54,876,963 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605342,955,305 - 43,064,586 (-)NCBIVero_WHO_p1.0
Sptlc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473424,281,482 - 24,400,870 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003808880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000029213   ⟹   ENSPPAP00000007139
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1477,266,545 - 77,370,663 (-)Ensembl
RefSeq Acc Id: XM_003808880   ⟹   XP_003808928
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11477,266,545 - 77,370,663 (-)NCBI
Mhudiblu_PPA_v01458,066,123 - 58,170,472 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003808928 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003808928   ⟸   XM_003808880
- Sequence:
RefSeq Acc Id: ENSPPAP00000007139   ⟸   ENSPPAT00000029213
Protein Domains
Aminotran_1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000007139 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000029213 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_II_pyridoxalP_BS UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
KEGG Report pps:100995803 UniProtKB/TrEMBL
NCBI Gene SPTLC2 ENTREZGENE
Pfam Aminotran_1_2 UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A2R8ZTG0_PANPA UniProtKB/TrEMBL