THTPA (thiamine triphosphatase) - Rat Genome Database

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Gene: THTPA (thiamine triphosphatase) Pan paniscus
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Symbol: THTPA
Name: thiamine triphosphatase
RGD ID: 11713803
Description: ENCODES a protein that exhibits hydrolase activity (inferred); magnesium ion binding (inferred); metal ion binding (inferred); INVOLVED IN dephosphorylation (ortholog); PARTICIPATES IN thiamine metabolic pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); Marsili syndrome (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thiamine-triphosphatase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,986,749 - 24,990,593 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,203,241 - 24,207,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,374,439 - 4,378,028 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,467,506 - 22,471,356 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,467,506 - 22,471,356 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
THTPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,986,749 - 24,990,593 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,203,241 - 24,207,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,374,439 - 4,378,028 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,467,506 - 22,471,356 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,467,506 - 22,471,356 (+)Ensemblpanpan1.1panPan2
THTPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,511,760 - 23,560,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,555,988 - 23,560,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,980,969 - 24,029,480 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,095,071 - 23,098,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,095,070 - 23,098,592NCBI
Celera143,887,868 - 3,891,457 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef144,097,332 - 4,145,309 (+)NCBIHuRef
CHM1_11423,979,628 - 24,027,450 (+)NCBICHM1_1
T2T-CHM13v2.01417,712,320 - 17,760,830 (+)NCBIT2T-CHM13v2.0
Thtpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,332,241 - 55,336,452 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,332,241 - 55,336,443 (+)EnsemblGRCm39 Ensembl
GRCm381455,094,784 - 55,098,995 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,094,784 - 55,098,986 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,713,621 - 55,717,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,048,906 - 54,053,053 (+)NCBIMGSCv36mm8
Celera1452,900,681 - 52,904,892 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.07NCBI
Thtpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,536,297 - 32,541,537 (+)NCBIGRCr8
mRatBN7.21528,567,619 - 28,571,580 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,567,323 - 28,571,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,413,650 - 30,417,289 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,560,842 - 31,564,481 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,803,502 - 29,807,141 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,755,157 - 33,759,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,755,478 - 33,759,115 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,640,608 - 37,646,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,201,426 - 33,205,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,217,763 - 33,219,293 (+)NCBI
Celera1528,145,924 - 28,149,563 (+)NCBICelera
Cytogenetic Map15p13NCBI
Thtpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,804,258 - 36,808,091 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,803,721 - 36,808,094 (-)NCBIChiLan1.0ChiLan1.0
THTPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,781,931 - 3,785,093 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,782,163 - 3,785,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,703,805 - 3,708,801 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,892,212 - 3,897,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,892,317 - 3,898,687 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,584,212 - 3,588,417 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,644,873 - 3,649,869 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,906,958 - 3,911,954 (+)NCBIUU_Cfam_GSD_1.0
Thtpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,485,267 - 35,532,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722855,975 - 863,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722858,119 - 904,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THTPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,545,973 - 75,552,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,548,430 - 75,553,721 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,862,681 - 80,867,802 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THTPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,883,363 - 23,930,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,926,813 - 23,929,981 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,487,907 - 22,534,963 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thtpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,020,179 - 9,022,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,010,936 - 9,022,935 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000030537   ⟹   ENSPPAP00000007916
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1422,467,506 - 22,471,356 (+)Ensembl
RefSeq Acc Id: XM_003808083   ⟹   XP_003808131
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,986,749 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,241 - 24,207,085 (+)NCBI
Mhudiblu_PPA_v0144,374,449 - 4,378,028 (+)NCBI
PanPan1.11422,467,506 - 22,471,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960149   ⟹   XP_008958397
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,986,997 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,489 - 24,207,085 (+)NCBI
Mhudiblu_PPA_v0144,374,439 - 4,378,028 (+)NCBI
PanPan1.11422,467,506 - 22,471,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960152   ⟹   XP_008958400
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,986,998 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,490 - 24,207,085 (+)NCBI
Mhudiblu_PPA_v0144,374,439 - 4,378,028 (+)NCBI
PanPan1.11422,467,506 - 22,471,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960154   ⟹   XP_008958402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,986,998 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,490 - 24,207,085 (+)NCBI
Mhudiblu_PPA_v0144,374,439 - 4,378,028 (+)NCBI
PanPan1.11422,467,506 - 22,471,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034937314   ⟹   XP_034793205
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,987,029 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,521 - 24,207,085 (+)NCBI
Mhudiblu_PPA_v0144,374,448 - 4,378,028 (+)NCBI
RefSeq Acc Id: XM_057299776   ⟹   XP_057155759
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,986,998 - 24,990,593 (+)NCBI
NHGRI_mPanPan11424,203,490 - 24,207,085 (+)NCBI
RefSeq Acc Id: XM_063596462   ⟹   XP_063452532
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21524,987,058 - 24,990,593 (+)NCBI
RefSeq Acc Id: XP_003808131   ⟸   XM_003808083
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008958397   ⟸   XM_008960149
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008958402   ⟸   XM_008960154
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008958400   ⟸   XM_008960152
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034793205   ⟸   XM_034937314
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZVM2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000007916   ⟸   ENSPPAT00000030537
RefSeq Acc Id: XP_057155759   ⟸   XM_057299776
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063452532   ⟸   XM_063596462
- Peptide Label: isoform X2
Protein Domains
CYTH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030537.1 UniProtKB/TrEMBL
Gene3D-CATH Hypothetical Protein Pfu-838710-001 UniProtKB/TrEMBL
InterPro CYTH-like_dom_sf UniProtKB/TrEMBL
  CYTH_domain UniProtKB/TrEMBL
  THTPA UniProtKB/TrEMBL
  ThTPase_euk UniProtKB/TrEMBL
KEGG Report pps:100977058 UniProtKB/TrEMBL
NCBI Gene THTPA ENTREZGENE
PANTHER PTHR14586 UniProtKB/TrEMBL
  THIAMINE-TRIPHOSPHATASE UniProtKB/TrEMBL
Pfam CYTH UniProtKB/TrEMBL
PIRSF ThTPase UniProtKB/TrEMBL
PROSITE CYTH UniProtKB/TrEMBL
SMART CYTH UniProtKB/TrEMBL
Superfamily-SCOP SSF55154 UniProtKB/TrEMBL
UniProt A0A2R8ZVM2 ENTREZGENE, UniProtKB/TrEMBL