IFI6 (interferon alpha inducible protein 6)

Gene: IFI6 (interferon alpha inducible protein 6) Pan paniscus

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Symbol:

IFI6

Name:

interferon alpha inducible protein 6

RGD ID:

11712353

Description:

INVOLVED IN apoptotic process (inferred); apoptotic signaling pathway (inferred); cellular response to virus (inferred); ASSOCIATED WITH genetic disease (ortholog); Human Influenza (ortholog); major depressive disorder (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrial membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interferon alpha-inducible protein 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,178,540 - 199,184,619 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	198,294,957 - 198,301,035 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,929,129 - 26,935,205 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,972,859 - 27,978,922 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,972,866 - 27,978,890 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Human Influenza (ISO)

major depressive disorder (ISO)

Spontaneous Abortions (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

apoptotic signaling pathway (IEA)

cellular response to virus (IEA)

defense response to virus (IEA)

innate immune response (IEA)

intrinsic apoptotic signaling pathway (IEA)

negative regulation of apoptotic process (IEA)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA)

negative regulation of mitochondrial depolarization (IEA)

reactive oxygen species metabolic process (IEA)

regulation of epidermal growth factor receptor signaling pathway (IEA)

release of cytochrome c from mitochondria (IEA)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IEA)

mitochondrial membrane (IEA)

mitochondrion (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IFI6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,178,540 - 199,184,619 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	198,294,957 - 198,301,035 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,929,129 - 26,935,205 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,972,859 - 27,978,922 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,972,866 - 27,978,890 (-)	Ensembl	panpan1.1		panPan2

IFI6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	27,666,064 - 27,672,192 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	27,666,064 - 27,672,212 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	27,992,575 - 27,998,703 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	27,865,159 - 27,871,311 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	27,676,722 - 27,682,850	NCBI
Celera	1	26,388,246 - 26,394,372 (-)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	26,248,749 - 26,254,875 (-)	NCBI		HuRef
CHM1_1	1	28,107,855 - 28,113,985 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	27,507,374 - 27,513,475 (-)	NCBI		T2T-CHM13v2.0

IFI6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,638,657 - 72,642,648 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,638,705 - 72,642,648 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,216,644 - 69,220,624 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,200,610 - 73,204,589 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,200,645 - 73,204,588 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	70,027,033 - 70,031,008 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	71,037,970 - 71,041,945 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	72,034,465 - 72,038,444 (+)	NCBI		UU_Cfam_GSD_1.0

IFI6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,852,793 - 84,857,982 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	84,852,782 - 84,858,072 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

IFI6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,118,969 - 105,125,037 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,118,645 - 105,125,151 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	11,339,635 - 11,345,695 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003828075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008953397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000040404 ⟹ ENSPPAP00000017693

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	27,972,866 - 27,978,890 (-)	Ensembl

RefSeq Acc Id:

XM_003828075 ⟹ XP_003828123

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	199,178,541 - 199,184,619 (+)	NCBI
NHGRI_mPanPan1	1	198,294,958 - 198,301,035 (+)	NCBI
Mhudiblu_PPA_v0	1	26,929,129 - 26,935,204 (-)	NCBI
PanPan1.1	1	27,972,859 - 27,978,921 (-)	NCBI

Sequence:

show sequence

TGCCTAGGGTGAGACGTGGGAGGATCCGCAAGTGATGATAAAAAGCCAGCCTTCAGCCGGAGAA
CCGTTTACTCGCTGCTGTGCCCATCTATCAGCAGGCTCCGGGCTGAAGATTGCTTCTCTTCTCT
CCTCCAAGGTCTAGTGACGGAGCCCACGCGCGGCGCCACCATGCGGCAGAAGGCGGTATCGCTT
TTCTTGTGCTACCTGCTGCTCTTCACTTGCAGCGGGGTGGAGGCAGGTAAGAAAAAGTGCTCGG
AGAGCTCGGACAGCGGCTCCGGGTTCTGGAAGGCCCTGACCTTCATGGCCGTCGGAGGAGGACT
CGCAGTCGCCGGGCTGCCCGCGCTGGGCTTCACCGGCGCCGGCATCGCGGCCAACTCGGTGGCT
GCCTCGCTGATGAGCTGGTCTGCGATCCTGAATGGGGGCGGCGTGCCCGCCGGGGGGCTAGTGG
CCACGCTGCAGAGCCTCGGGGCTGGTGGCAGCAGCGTCATCACAGGTAATATTGGTGCCCTGAT
GGGCTACGCCACCCACAAGTATCTCGATAGTGAGGAGGATGAGGAGTAGCCAGCAGCTCCCAGA
ACCTCTTCTTCCTTCTTGGCCTAACTCTTCCAGTTAGGATCTAGAACTTTGCCTTTTTTTTTTT
TTTTTTTTGTAGATGGGTTCTCACTATGTTGTCCAGGCTAGAGTGCAGTGGCTATTCACAGATG
CGAACATAGTACACTGCAGCCTCCAACTCCTAGCCTCAAGTGATCCTCCTGTCTCAACCTCCCA
AGTAGGATTACAAGCATGCGTCGACGACGCCCAGAATCCAGAACTTTGTCTATCACTCTCCCCA
ACAACCTAGATGTGAAAACAGAATAAACTTCACCCAGAAAACAC

hide sequence

RefSeq Acc Id:

XM_008953397 ⟹ XP_008951645

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	199,178,540 - 199,184,619 (+)	NCBI
NHGRI_mPanPan1	1	198,294,957 - 198,301,035 (+)	NCBI
Mhudiblu_PPA_v0	1	26,929,129 - 26,935,205 (-)	NCBI
PanPan1.1	1	27,972,859 - 27,978,922 (-)	NCBI

Sequence:

show sequence

CTGCCTAGGGTGAGACGTGGGAGGATCCGCAAGTGATGATAAAAAGCCAGCCTTCAGCCGGAGA
ACCGTTTACTCGCTGCTGTGCCCATCTATCAGCAGGCTCCGGGCTGAAGATTGCTTCTCTTCTC
TCCTCCAAGGTCTAGTGACGGAGCCCACGCGCGGCGCCACCATGCGGCAGAAGGCGGTATCGCT
TTTCTTGTGCTACCTGCTGCTCTTCACTTGCAGCGGGGTGGAGGCAGGTGAGAATGCGGGTAAG
AAAAAGTGCTCGGAGAGCTCGGACAGCGGCTCCGGGTTCTGGAAGGCCCTGACCTTCATGGCCG
TCGGAGGAGGACTCGCAGTCGCCGGGCTGCCCGCGCTGGGCTTCACCGGCGCCGGCATCGCGGC
CAACTCGGTGGCTGCCTCGCTGATGAGCTGGTCTGCGATCCTGAATGGGGGCGGCGTGCCCGCC
GGGGGGCTAGTGGCCACGCTGCAGAGCCTCGGGGCTGGTGGCAGCAGCGTCATCACAGGTAATA
TTGGTGCCCTGATGGGCTACGCCACCCACAAGTATCTCGATAGTGAGGAGGATGAGGAGTAGCC
AGCAGCTCCCAGAACCTCTTCTTCCTTCTTGGCCTAACTCTTCCAGTTAGGATCTAGAACTTTG
CCTTTTTTTTTTTTTTTTTTTGTAGATGGGTTCTCACTATGTTGTCCAGGCTAGAGTGCAGTGG
CTATTCACAGATGCGAACATAGTACACTGCAGCCTCCAACTCCTAGCCTCAAGTGATCCTCCTG
TCTCAACCTCCCAAGTAGGATTACAAGCATGCGTCGACGACGCCCAGAATCCAGAACTTTGTCT
ATCACTCTCCCCAACAACCTAGATGTGAAAACAGAATAAACTTCACCCAGAAAACAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003828123	(Get FASTA)	NCBI Sequence Viewer
	XP_008951645	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000017693
	ENSPPAP00000017693.1

RefSeq Acc Id:	XP_003828123 ⟸ XM_003828075
- Peptide Label:	isoform X2
- Sequence:	show sequence MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALGFTGA GIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVITGNIGALMGYATHKYLDSEED EE hide sequence

RefSeq Acc Id:	XP_008951645 ⟸ XM_008953397
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9AKP9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRQKAVSLFLCYLLLFTCSGVEAGENAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALG FTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVITGNIGALMGYATHKYLD SEEDEE hide sequence

RefSeq Acc Id:

ENSPPAP00000017693 ⟸ ENSPPAT00000040404

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031946	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040404.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.110.10	UniProtKB/TrEMBL
InterPro	IFI6/IFI27-like	UniProtKB/TrEMBL
	IFI6/IFI27-like_sf	UniProtKB/TrEMBL
NCBI Gene	IFI6	ENTREZGENE
PANTHER	INTERFERON ALPHA-INDUCIBLE PROTEIN 6	UniProtKB/TrEMBL
	PTHR16932	UniProtKB/TrEMBL
Pfam	Ifi-6-16	UniProtKB/TrEMBL
UniProt	A0A2R9AKP9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD