CAPN5 (calpain 5) - Rat Genome Database

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Gene: CAPN5 (calpain 5) Pan paniscus
Analyze
Symbol: CAPN5
Name: calpain 5
RGD ID: 11706442
Description: ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN granulosa cell differentiation (ortholog); luteinization (ortholog); ovarian follicle development (ortholog); ASSOCIATED WITH fundus dystrophy (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); synapse (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calpain-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,986,781 - 78,043,703 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,034,987 - 79,091,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,118,036 - 72,174,920 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,778,879 - 75,817,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,778,879 - 75,817,827 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA)
cytoplasm  (IEA)
synapse  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,986,781 - 78,043,703 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,034,987 - 79,091,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,118,036 - 72,174,920 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,778,879 - 75,817,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,778,879 - 75,817,827 (+)Ensemblpanpan1.1panPan2
CAPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,066,971 - 77,126,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,066,961 - 77,126,155 (+)EnsemblGRCh38hg38GRCh38
GRCh371176,778,018 - 76,837,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,455,640 - 76,514,849 (+)NCBINCBI36Build 36hg18NCBI36
Build 341176,455,658 - 76,514,844NCBI
Celera1174,085,463 - 74,144,685 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1173,075,693 - 73,134,573 (+)NCBIHuRef
CHM1_11176,661,081 - 76,720,452 (+)NCBICHM1_1
T2T-CHM13v2.01176,997,312 - 77,056,732 (+)NCBIT2T-CHM13v2.0
Capn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,770,766 - 97,828,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,770,766 - 97,827,481 (-)EnsemblGRCm39 Ensembl
GRCm38798,121,559 - 98,178,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,121,559 - 98,178,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv377105,270,075 - 105,326,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,996,757 - 98,053,385 (-)NCBIMGSCv36mm8
Celera798,442,279 - 98,499,525 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Capn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,827,474 - 161,884,142 (-)NCBIGRCr8
mRatBN7.21152,416,252 - 152,472,923 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,416,252 - 152,472,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,403,310 - 160,459,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,583,490 - 167,640,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,457,009 - 160,513,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,073,134 - 163,129,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,073,124 - 163,129,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,278,330 - 169,336,574 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,366,678 - 155,421,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,445,083 - 155,499,584 (-)NCBI
Celera1150,507,123 - 150,563,735 (-)NCBICelera
Cytogenetic Map1q32NCBI
Capn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,651,207 - 14,706,887 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541414,652,578 - 14,706,833 (-)NCBIChiLan1.0ChiLan1.0
CAPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,626,090 - 21,678,545 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2121,627,791 - 21,678,880 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,453,573 - 21,506,018 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02121,825,703 - 21,878,142 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2121,825,714 - 21,876,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12121,601,212 - 21,653,579 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,817,385 - 21,869,821 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,741,079 - 21,793,561 (-)NCBIUU_Cfam_GSD_1.0
Capn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,093,284 - 64,148,772 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364985,692,867 - 5,748,416 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364985,692,910 - 5,747,329 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,207,636 - 11,246,711 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1911,194,302 - 11,246,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,288,762 - 12,341,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,276,310 - 68,334,254 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,293,739 - 68,334,250 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604357,441,383 - 57,499,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624863148,889 - 202,952 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624863148,941 - 202,853 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034933422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000044742   ⟹   ENSPPAP00000021938
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1175,778,879 - 75,817,827 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044748   ⟹   ENSPPAP00000021944
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1175,778,909 - 75,815,562 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044752   ⟹   ENSPPAP00000021948
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1175,778,909 - 75,815,431 (+)Ensembl
RefSeq Acc Id: XM_034933422   ⟹   XP_034789313
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2977,986,781 - 78,043,703 (+)NCBI
NHGRI_mPanPan11179,034,987 - 79,091,265 (+)NCBI
Mhudiblu_PPA_v01172,118,036 - 72,174,920 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034789313 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000021938.1
  ENSPPAP00000021944.1
  ENSPPAP00000021948.1
Reference Protein Sequences
RefSeq Acc Id: XP_034789313   ⟸   XM_034933422
- UniProtKB: A0A2R9AXC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000021938   ⟸   ENSPPAT00000044742
RefSeq Acc Id: ENSPPAP00000021944   ⟸   ENSPPAT00000044748
RefSeq Acc Id: ENSPPAP00000021948   ⟸   ENSPPAT00000044752
Protein Domains
C2   Calpain catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044742.1 UniProtKB/TrEMBL
  ENSPPAT00000044748.1 UniProtKB/TrEMBL
  ENSPPAT00000044752.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.380 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro C2_Calpain UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_III UniProtKB/TrEMBL
  Calpain_cysteine_protease UniProtKB/TrEMBL
  Calpain_domain_III UniProtKB/TrEMBL
  Calpain_III UniProtKB/TrEMBL
  Calpain_III_sf UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Peptidase_C2_calpain_cat UniProtKB/TrEMBL
NCBI Gene CAPN5 ENTREZGENE
PANTHER CALPAIN UniProtKB/TrEMBL
  CALPAIN-5 UniProtKB/TrEMBL
Pfam Calpain_III UniProtKB/TrEMBL
  Peptidase_C2 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PRINTS CALPAIN UniProtKB/TrEMBL
PROSITE CALPAIN_CAT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
SMART calpain_III UniProtKB/TrEMBL
  CysPc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF49758 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A2R9AXC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AXD1_PANPA UniProtKB/TrEMBL
  A0A2R9AXK1_PANPA UniProtKB/TrEMBL