TRPV4 (transient receptor potential cation channel subfamily V member 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: TRPV4 (transient receptor potential cation channel subfamily V member 4) Pan paniscus
Analyze
Symbol: TRPV4
Name: transient receptor potential cation channel subfamily V member 4
RGD ID: 11705898
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); alpha-tubulin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); ATP export (ortholog); ATP transport (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 5 (ortholog); Auditory Neuropathy (ortholog); autosomal dominant distal hereditary motor neuronopathy (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cortical actin cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,846,362 - 117,896,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amyotrophic lateral sclerosis type 5  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
autosomal dominant distal hereditary motor neuronopathy 8  (ISO)
autosomal dominant nonsyndromic deafness 25  (ISO)
bone disease  (ISO)
brachyolmia  (ISO)
Brachyolmia Type 2  (ISO)
Brachyolmia Type 3  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease axonal type 2C  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
chronic obstructive pulmonary disease  (ISO)
clubfoot  (ISO)
connective tissue disease  (ISO)
Digital Arthropathy-Brachydactyly, Familial  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hyponatremia  (ISO)
leukocyte adhesion deficiency 1  (ISO)
metatropic dysplasia  (ISO)
myoepithelioma  (ISO)
neuromuscular disease  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
parastremmatic dwarfism  (ISO)
pulmonary hypertension  (ISO)
scapuloperoneal spinal muscular atrophy  (ISO)
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal  (ISO)
spinal muscular atrophy  (ISO)
spinocerebellar ataxia with axonal neuropathy 2  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondyloepiphyseal dysplasia Maroteaux type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia Kozlowski type  (ISO)
Urination Disorders  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament organization  (IEA)
ATP export  (ISO)
ATP transport  (ISO)
blood vessel endothelial cell delamination  (IEA)
calcium ion import  (IEA)
calcium ion import across plasma membrane  (IEA)
calcium ion import into cytosol  (IEA)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (IEA)
cartilage development involved in endochondral bone morphogenesis  (IEA)
cartilage homeostasis  (ISO)
cell-cell junction assembly  (IEA)
cellular hypotonic response  (IEA)
cellular hypotonic salinity response  (IEA)
cellular response to heat  (IEA)
cellular response to osmotic stress  (IEA)
cortical microtubule organization  (ISO)
diet induced thermogenesis  (IEA)
energy homeostasis  (IEA)
glucose homeostasis  (IEA)
hyperosmotic salinity response  (IEA,ISO)
hypotonic response  (ISO)
intracellular calcium ion homeostasis  (IEA)
microtubule polymerization  (ISO)
monoatomic ion transport  (IEA)
multicellular organismal-level water homeostasis  (IEA)
negative regulation of brown fat cell differentiation  (IEA)
negative regulation of cell volume  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
osmosensory signaling pathway  (IEA,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage inflammatory protein 1 alpha production  (IEA)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of microtubule depolymerization  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of striated muscle contraction  (ISO)
positive regulation of vascular permeability  (IEA)
regulation of aerobic respiration  (IEA)
regulation of blood pressure  (ISO)
regulation of heart rate  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of response to osmotic stress  (IEA,ISO)
relaxation of vascular associated smooth muscle  (ISO)
response to fatty acid  (ISO)
response to hypoxia  (ISO)
response to insulin  (IEA)
response to lipopolysaccharide  (ISO)
response to osmotic stress  (IEA,ISO)
transmembrane transport  (IEA)
vasopressin secretion  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRPV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,846,362 - 117,896,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
TRPV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,783,087 - 109,833,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,783,087 - 109,833,406 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,220,892 - 110,271,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,705,277 - 108,755,595 (-)NCBINCBI36Build 36hg18NCBI36
Celera12109,845,179 - 109,895,568 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,237,035 - 107,287,147 (-)NCBIHuRef
CHM1_112110,188,702 - 110,239,020 (-)NCBICHM1_1
T2T-CHM13v2.012109,758,559 - 109,808,862 (-)NCBIT2T-CHM13v2.0
Trpv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,760,213 - 114,796,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,760,213 - 114,796,482 (-)EnsemblGRCm39 Ensembl
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBIMGSCv36mm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Trpv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,599,161 - 47,638,143 (+)NCBIGRCr8
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,106,237 - 43,144,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,719,815 - 43,758,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,780,312 - 42,818,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
Trpv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
TRPV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,293,334 - 17,330,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,262,100 - 17,330,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,472,505 - 18,493,002 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,652,672 - 17,673,399 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,652,672 - 17,673,984 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,683,516 - 18,704,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,643,537 - 17,664,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,660,529 - 17,681,097 (+)NCBIUU_Cfam_GSD_1.0
Trpv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,028,138 - 144,051,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,424,549 - 1,447,516 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,424,526 - 1,447,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,020,972 - 105,072,660 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037140,046,822 - 140,098,634 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,675,625 - 10,685,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000036069   ⟹   ENSPPAP00000013398
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000036076   ⟹   ENSPPAP00000013405
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12110,754,238 - 110,786,120 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000036084   ⟹   ENSPPAP00000013412
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12110,754,767 - 110,786,093 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000036094   ⟹   ENSPPAP00000013422
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12110,757,944 - 110,786,093 (-)Ensembl
RefSeq Acc Id: XM_034934437   ⟹   XP_034790328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBI
NHGRI_mPanPan112117,846,362 - 117,896,716 (-)NCBI
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBI
RefSeq Acc Id: XM_063593192   ⟹   XP_063449262
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBI
RefSeq Acc Id: XR_010108869
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210117,850,623 - 117,900,314 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034790328 (Get FASTA)   NCBI Sequence Viewer  
  XP_063449262 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013398.1
  ENSPPAP00000013405.1
  ENSPPAP00000013412.1
  ENSPPAP00000013422.1
RefSeq Acc Id: XP_034790328   ⟸   XM_034934437
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A7Z8 (UniProtKB/TrEMBL),   A0A2R9AD55 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000013422   ⟸   ENSPPAT00000036094
Ensembl Acc Id: ENSPPAP00000013412   ⟸   ENSPPAT00000036084
Ensembl Acc Id: ENSPPAP00000013405   ⟸   ENSPPAT00000036076
Ensembl Acc Id: ENSPPAP00000013398   ⟸   ENSPPAT00000036069
RefSeq Acc Id: XP_063449262   ⟸   XM_063593192
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A928 (UniProtKB/TrEMBL),   A0A2R9AD55 (UniProtKB/TrEMBL)
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036069.1 UniProtKB/TrEMBL
  ENSPPAT00000036076.1 UniProtKB/TrEMBL
  ENSPPAT00000036084.1 UniProtKB/TrEMBL
  ENSPPAT00000036094.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  TRPV UniProtKB/TrEMBL
  TRPV1-4_channel UniProtKB/TrEMBL
  TRPV4_channel UniProtKB/TrEMBL
NCBI Gene TRPV4 ENTREZGENE
PANTHER PTHR10582 UniProtKB/TrEMBL
  PTHR10582:SF4 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS TRPVRECEPTOR UniProtKB/TrEMBL
  VRL2RECEPTOR UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A2R9A7Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A928 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AD46_PANPA UniProtKB/TrEMBL
  A0A2R9AD55 ENTREZGENE, UniProtKB/TrEMBL