CNKSR3 (CNKSR family member 3) - Rat Genome Database

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Gene: CNKSR3 (CNKSR family member 3) Pan paniscus
Analyze
Symbol: CNKSR3
Name: CNKSR family member 3
RGD ID: 11695417
Description: INVOLVED IN negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of peptidyl-serine phosphorylation (ortholog); positive regulation of sodium ion transport (ortholog); ASSOCIATED WITH chromosome 6q24-q25 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: connector enhancer of kinase suppressor of ras 3; interaction protein for cytohesin exchange factors 1; interactor protein for cytohesin exchange factors 1; interactor protein for cytohesin exchange factors 1-like; IPCEF1; LOC100978941; LOC100989962; LOC103784948
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,428,046 - 174,534,938 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16172,319,737 - 172,425,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06152,221,458 - 152,326,885 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,666,986 - 158,292,640 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CNKSR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,428,046 - 174,534,938 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16172,319,737 - 172,425,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06152,221,458 - 152,326,885 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,666,986 - 158,292,640 (-)NCBIpanpan1.1PanPan1.1panPan2
CNKSR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,387,515 - 154,510,685 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,387,515 - 154,510,685 (-)EnsemblGRCh38hg38GRCh38
GRCh376154,708,649 - 154,831,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,768,125 - 154,873,445 (-)NCBINCBI36Build 36hg18NCBI36
Build 346154,818,546 - 154,923,906NCBI
Celera6155,460,772 - 155,566,082 (-)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6152,289,215 - 152,394,549 (-)NCBIHuRef
CHM1_16154,989,508 - 155,094,800 (-)NCBICHM1_1
T2T-CHM13v2.06155,589,037 - 155,712,112 (-)NCBIT2T-CHM13v2.0
Cnksr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,069,061 - 7,162,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,069,063 - 7,162,237 (-)EnsemblGRCm39 Ensembl
GRCm38107,119,061 - 7,212,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,119,063 - 7,212,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv37103,134,304 - 3,227,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,134,304 - 3,227,479 (+)NCBIMGSCv36mm8
Celera107,081,303 - 7,175,417 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
Cnksr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,904,581 - 45,996,921 (-)NCBIGRCr8
mRatBN7.2143,499,273 - 43,591,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,499,487 - 43,591,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,040,536 - 44,133,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0150,027,769 - 50,120,372 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,116,025 - 44,208,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,789,797 - 43,884,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,789,791 - 43,884,267 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,119,654 - 45,213,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,865,904 - 37,958,862 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1137,868,848 - 37,961,807 (-)NCBI
Celera139,135,338 - 39,227,832 (-)NCBICelera
Cytogenetic Map1q11NCBI
Cnksr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,524,333 - 7,616,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554397,524,401 - 7,616,447 (+)NCBIChiLan1.0ChiLan1.0
CNKSR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1144,280,132 - 44,361,138 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl144,070,004 - 44,363,107 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,116,969 - 45,205,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,462,865 - 44,552,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,253,530 - 44,552,166 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,330,159 - 44,418,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0144,202,964 - 44,291,122 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,758,957 - 44,847,009 (-)NCBIUU_Cfam_GSD_1.0
Cnksr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,541,292 - 139,628,404 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,792,048 - 6,880,445 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,792,925 - 6,880,300 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNKSR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,297,676 - 12,396,688 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,297,740 - 12,396,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,301,232 - 14,451,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNKSR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,945,080 - 82,050,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,943,423 - 82,050,175 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604054,347,357 - 54,454,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnksr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247853,805,389 - 3,902,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247853,805,829 - 3,905,554 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034963107   ⟹   XP_034818998
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25174,428,046 - 174,534,931 (-)NCBI
NHGRI_mPanPan16172,319,737 - 172,425,193 (-)NCBI
Mhudiblu_PPA_v06152,221,458 - 152,326,885 (-)NCBI
RefSeq Acc Id: XM_034963110   ⟹   XP_034819001
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25174,428,046 - 174,532,331 (-)NCBI
NHGRI_mPanPan16172,319,737 - 172,423,444 (-)NCBI
Mhudiblu_PPA_v06152,221,458 - 152,325,223 (-)NCBI
RefSeq Acc Id: XM_034963111   ⟹   XP_034819002
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25174,428,046 - 174,532,333 (-)NCBI
NHGRI_mPanPan16172,319,737 - 172,423,945 (-)NCBI
Mhudiblu_PPA_v06152,221,458 - 152,325,646 (-)NCBI
RefSeq Acc Id: XM_034963112   ⟹   XP_034819003
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25174,429,108 - 174,534,938 (-)NCBI
NHGRI_mPanPan16172,320,800 - 172,425,198 (-)NCBI
Mhudiblu_PPA_v06152,222,520 - 152,326,885 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034818998 (Get FASTA)   NCBI Sequence Viewer  
  XP_034819001 (Get FASTA)   NCBI Sequence Viewer  
  XP_034819002 (Get FASTA)   NCBI Sequence Viewer  
  XP_034819003 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031803.1
  ENSPPAP00000034825.1
Reference Protein Sequences
RefSeq Acc Id: XP_034818998   ⟸   XM_034963107
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034819002   ⟸   XM_034963111
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C211 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034819001   ⟸   XM_034963110
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C211 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034819003   ⟸   XM_034963112
- Peptide Label: isoform X4
Protein Domains
CRIC   PDZ   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038809 UniProtKB/TrEMBL
  ENSPPAG00000040246 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054668.1 UniProtKB/TrEMBL
  ENSPPAT00000057710.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  Transcription Factor, Ets-1 UniProtKB/TrEMBL
InterPro CNK1-3_SAM UniProtKB/TrEMBL
  CNK2/3_dom UniProtKB/TrEMBL
  CRIC_domain UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
NCBI Gene CNKSR3 ENTREZGENE
PANTHER CNK3/IPCEF1 FUSION PROTEIN-RELATED UniProtKB/TrEMBL
  CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS UniProtKB/TrEMBL
  CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3 UniProtKB/TrEMBL
Pfam CNK2_3_dom UniProtKB/TrEMBL
  CRIC_ras_sig UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PROSITE CRIC UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP PDZ domain-like UniProtKB/TrEMBL
  SAM/Pointed domain UniProtKB/TrEMBL
UniProt A0A2R9BZ83_PANPA UniProtKB/TrEMBL
  A0A2R9C211 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 CNKSR3  CNKSR family member 3  LOC100978941  CNK3/IPCEF1 fusion protein  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC100978941  CNK3/IPCEF1 fusion protein  LOC100989962  interactor protein for cytohesin exchange factors 1-like  Data merged from RGD:11830279 737654 PROVISIONAL
2018-05-08 LOC100978941  CNK3/IPCEF1 fusion protein  IPCEF1  interaction protein for cytohesin exchange factors 1  Data merged from RGD:11991028 737654 PROVISIONAL
2018-05-08 LOC100978941  CNK3/IPCEF1 fusion protein  LOC103784948  connector enhancer of kinase suppressor of ras 3  Data merged from RGD:11993563 737654 PROVISIONAL
2018-05-08 LOC100978941  CNK3/IPCEF1 fusion protein  CNKSR3  CNKSR family member 3  Symbol and/or name change 5135510 APPROVED