TOP1MT (DNA topoisomerase I mitochondrial)

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Gene: TOP1MT (DNA topoisomerase I mitochondrial) Pan paniscus

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Symbol:

TOP1MT

Name:

DNA topoisomerase I mitochondrial

RGD ID:

11687968

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN DNA replication (inferred); DNA topological change (inferred); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); holoprosencephaly (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase I, mitochondrial; topoisomerase (DNA) I, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	160,779,424 - 160,836,852 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	136,303,888 - 136,354,388 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	140,056,468 - 140,106,510 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	143,077,224 - 143,125,987 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brown-Vialetto-Van Laere syndrome 2 (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

holoprosencephaly (ISO)

sensorineural hearing loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA replication (IEA)

DNA topological change (IEA)

Cellular Component

chromosome (IEA)

mitochondrial nucleoid (IEA)

mitochondrion (ISO)

nucleoplasm (ISO)

Molecular Function

DNA binding (IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP1MT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	160,779,424 - 160,836,852 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	136,303,888 - 136,354,388 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	140,056,468 - 140,106,510 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	143,077,224 - 143,125,987 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

TOP1MT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	143,309,324 - 143,359,977 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	143,304,384 - 143,359,979 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	144,391,494 - 144,442,147 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	144,462,901 - 144,488,425 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	144,462,904 - 144,488,425	NCBI
Celera	8	140,700,651 - 140,727,260 (-)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	139,629,915 - 139,695,642 (-)	NCBI		HuRef
CHM1_1	8	144,431,738 - 144,482,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	144,456,634 - 144,507,610 (-)	NCBI		T2T-CHM13v2.0

Top1mt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	75,528,878 - 75,551,184 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	75,528,884 - 75,550,649 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	75,657,033 - 75,678,800 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	75,657,035 - 75,678,800 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	75,487,463 - 75,509,220 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	75,484,288 - 75,506,045 (-)	NCBI		MGSCv36	mm8
Celera	15	77,157,202 - 77,179,081 (-)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	34.69	NCBI

Top1mt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,223,269 - 109,248,855 (-)	NCBI		GRCr8
mRatBN7.2	7	107,338,092 - 107,368,125 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,342,527 - 107,366,049 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,077,854 - 109,100,706 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,301,524 - 111,324,376 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,247,445 - 111,270,297 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,688,801 - 116,714,421 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,688,701 - 116,712,387 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,582,993 - 116,608,875 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,596,083 - 113,619,109 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,630,312 - 113,653,339 (-)	NCBI
Celera	7	103,705,366 - 103,728,376 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Top1mt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,021,563 - 2,046,190 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,020,884 - 2,045,939 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP1MT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	1,148,890 - 1,188,130 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	1,134,179 - 1,188,149 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	1,068,174 - 1,125,241 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103237562
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	137,523,739 - 137,574,672 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	137,523,955 - 137,552,407 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023667018	8,188 - 24,004 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top1mt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	13,417,185 - 13,441,097 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003819457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034966766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055117059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055117061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010113044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008972827 ⟹ XP_008971075

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,786,323 - 160,810,781 (-)	NCBI
NHGRI_mPanPan1	8	136,304,100 - 136,328,403 (-)	NCBI
Mhudiblu_PPA_v0	8	140,056,662 - 140,080,963 (-)	NCBI
PanPan1.1	8	143,077,417 - 143,101,852 (-)	NCBI

Sequence:

show sequence

CGGCTCTGACGCTGCTCGGGGAGGTCCCCCGCCGCCCGGCCTCCCGGGGTGTCCCGGGCTCGCG
CAGGACGCAGAAGGGCAGTGGAGCCAGGTGGGAGAAGGAGAAGCACGAAGACGGGGTGAAGTGG
AGACAGCTGGAGCACAAGGGCCCGTACTTCGCACCCCCATACGAGCCCCTTCCCGATGGAGTGC
GTTTCTTCTATGAAGGAAAGCCCGTGAGATTGAGCGTGGCAGCAGAGGAGGTCGCCACTTTTTA
TGGGAGGATGTTAGGTCATGAATACACAACAAAGGAGGTTTTCCGGAAGAACTTCTTCAATGAC
TGGCGAAAGGAAATGGCAGTGGAAGAGAGGGAAGTCATCAAGAGCCTGGACAAGTGTGACTTCA
CGGAGATCCACAGATACTTTGTGGACAAGGCCGCAGCCCGGAAAGTCCTGAGCAGGGAGGAGAA
GCAGAAGCTAAAAGAAGAGGCAGAAAAACTTCAGCAAGAGTTCGGCTACTGTATTTTAGATGGT
CACCAAGAAAAAATAGGCAATTTCAAGATTGAGCCGCCTGGCTTGTTCCGTGGCCGTGGCGACC
ATCCCAAGATGGGGATGCTGAAGAGAAGGATCATGCCAGAGGATGTGGTTATCAACTGCAGCAG
GGACTCGAAGATCCCCGAGCCGCCGGCGGGGCACCAGTGGAAGGAGGTGCGCTCCGATAACACC
GTCACGTGGCTGGCAGCTTGGACCGAGAGCGTTCAGAACTCCATCAAGTACATCATGCTGAACC
CTTGCTCGAAGCTGAAGGGGGAGACAGCTTGGCAGAAGTTTGAAACAGCTCGACGCCTGCGGGG
ATTCGTGGACGAGATCCGCTCCCAGTACCGGGCTGACTGGAAGTCTCGGGAAATGAAGACGAGA
CAGCGGGCGGTGGCCCTGTATTTCATCGATAAGCTGGCGCTGAGAGCAGGAAATGAGAAGGAGG
ACGGTGAGGCGGCCGACACCGTGGGCTGCTGTTCCCTCCGCGTGGAGCACGTCCAGCTGCACCC
AGAGGCCGATGGCTGCCAACACGTGGTGGAATTTGACTTTCTGGGGAAGGACTGCATCCGCTAC
TACAACAGAGTGCCGGTGGAGAAGCCGGTGTACAAGAACTTACAGCTCTTTATGGAGAGCAAGG
GCCCCCGGGACAACCTCTTCGACAGGCTGACCACGACCAGCCTGAACAAGCACCTCCAGGAGCT
GATGGACGGGCTGACGGCCAAGGTGTTCCGGACCTACAACGCCTCCATCACTCTGCAGGAGCAG
CTGCGGGCCCTGACGCGCGCTGAGGACAGCATAGCAGCTAAGATCTTATCCTACAACCGAGCCA
ACCGAGTCGTGGCCATTCTCTGCAACCATCAGCGAGCGACCCCCAGTACGTTTGAGAAGTCGAT
GCAGAATCTCCAGACGAAGATCCAGGCAAAGAAGGAGCAGGTGGCTGAGGCCAGGGCAGAGCTG
AGGAGGGCAAGGGCTGAGCACAAAGCCCAAGGGGATGGCAAGTCCAGGAGTGTCCTGGAGAAGA
AGAGGCGGCTCCTGGAGAAGCTGCAGGAGCAGCTGGCGCAGCTGAGTGTGCAGGCCACGGACAA
GGAGGAGAACAAGCAGGTGGCCCTGGGCACGTCCAAGCTCAACTACCTGGACCCCAGGATCAGC
ATTGCCTGGTGCGTGTGCCTGGGGTCTCAGTTCCCACCTGTGGCCTATGGGGGGCCTGGGTTTT
CCAGGAGGCCTCTGTTCAGTCCCAGCACTGCCCCTGTCCCGTGTCCCCTGGGGTCAGCACAGGC
CCTCCCTGTGACAGGGACCCATGATGCTGAGTCCTGTGTCATCAGCTCTCCCTGCCCTGAACGT
TCGGATGGACAGGGTGAAGTGGGGGTGCTGACAGTGGCCTGGGACTCGGAGGCATCAGGAGGGC
CTGTGGAGCTCAGCCTGCCCACAGGGAGTGGGAGGTGGCTGAGCGCCCTGCTCGGTGGACACCT
GGGCCACAGCAGGTTGTCTTTGACACCTCGCTGATGCTCCAGGGTGGCGGCGTGCGTGGGGTGG
GGTTGGCCTAGGGGAGCAGGTCCCAGCTACACCAGGCGGCTCTGGTGTCTCTGCTGCATGGAGG
ACGCTCGCCCTTGCCGAGCACCCTGACCTGGCCTTCAAGGTGGGTGAGTTGCCTGCTTGCCTGG
GCTGACGCTGCCTC

hide sequence

RefSeq Acc Id:

XM_008972830 ⟹ XP_008971078

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,786,323 - 160,810,799 (-)	NCBI
NHGRI_mPanPan1	8	136,303,888 - 136,328,393 (-)	NCBI
Mhudiblu_PPA_v0	8	140,056,468 - 140,080,963 (-)	NCBI
PanPan1.1	8	143,077,224 - 143,101,853 (-)	NCBI

Sequence:

show sequence

GCGGCTCTGACGCTGCTCGGGGAGGTCCCCCGCCGCCCGGCCTCCCGGGGTGTCCCGGGCTCGC
GCAGGACGCAGAAGGGCAGTGGAGCCAGGTGGGAGAAGGAGAAGCACGAAGACGGGGTGAAGTG
GAGACAGCTGGAGCACAAGGGCCCGTACTTCGCACCCCCATACGAGCCCCTTCCCGATGGAGTG
CGTTTCTTCTATGAAGGAAAGCCCGTGAGATTGAGCGTGGCAGCAGAGGAGGTCGCCACTTTTT
ATGGGAGGATGTTAGGTCATGAATACACAACAAAGGAGGTTTTCCGGAAGAACTTCTTCAATGA
CTGGCGAAAGGAAATGGCAGTGGAAGAGAGGGAAGTCATCAAGAGCCTGGACAAGTGTGACTTC
ACGGAGATCCACAGATACTTTGTGGACAAGGCCGCAGCCCGGAAAGTCCTGAGCAGGGAGGAGA
AGCAGAAGCTAAAAGAAGAGGCAGAAAAACTTCAGCAAGAGTTCGGCTACTGTATTTTAGATGG
TCACCAAGAAAAAATAGGCAATTTCAAGATTGAGCCGCCTGGCTTGTTCCGTGGCCGTGGCGAC
CATCCCAAGATGGGGATGCTGAAGAGAAGGATCATGCCAGAGGATGTGGTTATCAACTGCAGCA
GGGACTCGAAGATCCCCGAGCCGCCGGCGGGGCACCAGTGGAAGGAGGTGCGCTCCGATAACAC
CGTCACGTGGCTGGCAGCTTGGACCGAGAGCGTTCAGAACTCCATCAAGTACATCATGCTGAAC
CCTTGCTCGAAGCTGAAGGGGGAGACAGCTTGGCAGAAGTTTGAAACAGCTCGACGCCTGCGGG
GATTCGTGGACGAGATCCGCTCCCAGTACCGGGCTGACTGGAAGTCTCGGGAAATGAAGACGAG
ACAGCGGGCGGTGGCCCTGTATTTCATCGATAAGCTGGCGCTGAGAGCAGGAAATGAGAAGGAG
GACGGTGAGGCGGCCGACACCGTGGGCTGCTGTTCCCTCCGCGTGGAGCACGTCCAGCTGCACC
CAGAGGCCGATGGCTGCCAACACGTGGTGGAATTTGACTTTCTGGGGAAGGACTGCATCCGCTA
CTACAACAGAGTGCCGGTGGAGAAGCCGGTGTACAAGAACTTACAGCTCTTTATGGAGAGCAAG
GGCCCCCGGGACAACCTCTTCGACAGGCTGACCACGACCAGCCTGAACAAGCACCTCCAGGAGC
TGATGGACGGGCTGACGGCCAAGGTGTTCCGGACCTACAACGCCTCCATCACTCTGCAGGAGCA
GCTGCGGGCCCTGACGCGCGCTGAGGACAGCATAGCAGCTAAGATCTTATCCTACAACCGAGCC
AACCGAGTCGTGGCCATTCTCTGCAACCATCAGCGAGCGACCCCCAGTACGTTTGAGAAGTCGA
TGCAGAATCTCCAGACGAAGATCCAGGCAAAGAAGGAGCAGGTGGCTGAGGCCAGGGCAGAGCT
GAGGAGGGCAAGGGCTGAGCACAAAGCCCAAGGGGATGGCAAGTCCAGGAGTGTCCTGGAGAAG
AAGAGGCGGCTCCTGGAGAAGCTGCAGGAGCAGCTGGCGCAGCTGAGTGTGCAGGCCACGGACA
AGGAGGAGAACAAGCAGGTGGCCCTGGGCACGTCCAAGCTCAACTACCTGGACCCCAGGATCAG
CATTGCCTGGTGCAAGCGGTTCAGGGTGCCAGTGGAGAAGATCTACAGCAAAACACAGCGGGAG
AGGTTCGCCTGGGCTCTCGCCATGGCGGGAGAAGACTTTGAATTCTAACGACGAGCCGTGTTGA
AACTTCTTTTGTATGTGTGTGTGTTTTTTCACTATTAAAGCAGTACTGGGGAATTTTGTACAAT
AAAA

hide sequence

RefSeq Acc Id:

XM_034966766 ⟹ XP_034822657

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,786,323 - 160,810,720 (-)	NCBI
NHGRI_mPanPan1	8	136,304,100 - 136,328,349 (-)	NCBI
Mhudiblu_PPA_v0	8	140,056,662 - 140,080,918 (-)	NCBI

RefSeq Acc Id:

XM_055117059 ⟹ XP_054973034

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,786,323 - 160,836,852 (-)	NCBI
NHGRI_mPanPan1	8	136,303,888 - 136,354,382 (-)	NCBI

RefSeq Acc Id:

XM_055117061 ⟹ XP_054973036

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,786,323 - 160,810,737 (-)	NCBI
NHGRI_mPanPan1	8	136,303,888 - 136,328,359 (-)	NCBI

RefSeq Acc Id:

XM_063606955 ⟹ XP_063463025

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,779,424 - 160,836,845 (-)	NCBI

RefSeq Acc Id:

XM_063606956 ⟹ XP_063463026

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,779,424 - 160,810,776 (-)	NCBI

RefSeq Acc Id:

XR_010113044

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	160,779,424 - 160,810,772 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_008971075	(Get FASTA)	NCBI Sequence Viewer
	XP_008971078	(Get FASTA)	NCBI Sequence Viewer
	XP_034822657	(Get FASTA)	NCBI Sequence Viewer
	XP_054973034	(Get FASTA)	NCBI Sequence Viewer
	XP_054973036	(Get FASTA)	NCBI Sequence Viewer
	XP_063463025	(Get FASTA)	NCBI Sequence Viewer
	XP_063463026	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000022694.1
	ENSPPAP00000022697.1
	ENSPPAP00000022706.1
	ENSPPAP00000022723.1

RefSeq Acc Id:

XP_008971078 ⟸ XM_008972830

- Peptide Label:

isoform X3

- Sequence:

show sequence

MLGHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQK
LKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRIMPEDVVINCSRDS
KIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFV
DEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEA
DGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLTTTSLNKHLQELMD
GLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQN
LQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEE
NKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF

hide sequence

RefSeq Acc Id:

XP_008971075 ⟸ XM_008972827

- Peptide Label:

isoform X1

- Sequence:

show sequence

MLGHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQK
LKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRIMPEDVVINCSRDS
KIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFV
DEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEA
DGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLTTTSLNKHLQELMD
GLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQN
LQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEE
NKQVALGTSKLNYLDPRISIAWCVCLGSQFPPVAYGGPGFSRRPLFSPSTAPVPCPLGSAQALP
VTGTHDAESCVISSPCPERSDGQGEVGVLTVAWDSEASGGPVELSLPTGSGRWLSALLGGHLGH
SRLSLTPR

hide sequence

RefSeq Acc Id:	XP_034822657 ⟸ XM_034966766
- Peptide Label:	isoform X4
- UniProtKB:	A0A2R9B3H0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054973034 ⟸ XM_055117059
- Peptide Label:	isoform X6
- UniProtKB:	A0A2R9AZF9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054973036 ⟸ XM_055117061
- Peptide Label:	isoform X6
- UniProtKB:	A0A2R9AZF9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063463025 ⟸ XM_063606955
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063463026 ⟸ XM_063606956
- Peptide Label:	isoform X5

Protein Domains

DNA topoisomerase I DNA binding eukaryotic-type DNA topoisomerase I eukaryotic-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034530	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045506.1	UniProtKB/TrEMBL
	ENSPPAT00000045509.1	UniProtKB/TrEMBL
	ENSPPAT00000045519.1	UniProtKB/TrEMBL
	ENSPPAT00000045536.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.41	UniProtKB/TrEMBL
	1.10.132.10	UniProtKB/TrEMBL
	2.170.11.10	UniProtKB/TrEMBL
InterPro	DNA_brk_join_enz	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom1	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom2	UniProtKB/TrEMBL
	TopoI	UniProtKB/TrEMBL
	TopoI_AS	UniProtKB/TrEMBL
	TopoI_C_dom	UniProtKB/TrEMBL
	TopoI_cat_a-hlx-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_a/b-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk_N_sf	UniProtKB/TrEMBL
	TopoI_euk	UniProtKB/TrEMBL
	Topoisomerase_IB	UniProtKB/TrEMBL
KEGG Report	pps:100974665	UniProtKB/TrEMBL
NCBI Gene	TOP1MT	ENTREZGENE
PANTHER	DNA TOPOISOMERASE I	UniProtKB/TrEMBL
	DNA TOPOISOMERASE I, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	Topo_C_assoc	UniProtKB/TrEMBL
	Topoisom_I	UniProtKB/TrEMBL
	Topoisom_I_N	UniProtKB/TrEMBL
PRINTS	EUTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_EUK	UniProtKB/TrEMBL
SMART	TOPEUc	UniProtKB/TrEMBL
Superfamily-SCOP	Eukaryotic DNA topoisomerase I, dispensable insert domain	UniProtKB/TrEMBL
	SSF56349	UniProtKB/TrEMBL
	SSF56741	UniProtKB/TrEMBL
UniProt	A0A2R9AZF9	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9B0T0_PANPA	UniProtKB/TrEMBL
	A0A2R9B3H0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-08	TOP1MT	DNA topoisomerase I mitochondrial		topoisomerase (DNA) I, mitochondrial	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar