RUFY1 (RUN and FYVE domain containing 1) - Rat Genome Database

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Gene: RUFY1 (RUN and FYVE domain containing 1) Pan paniscus
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Symbol: RUFY1
Name: RUN and FYVE domain containing 1
RGD ID: 11687116
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN protein transport (ortholog); regulation of endocytosis (ortholog); small GTPase-mediated signal transduction (ortholog); ASSOCIATED WITH Ehlers-Danlos syndrome dermatosparaxis type (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis-1 (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); late endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RUN and FYVE domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,487,825 - 174,549,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,627,363 - 172,688,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,699,240 - 174,760,876 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,978,596 - 182,039,825 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,978,601 - 182,039,332 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RUFY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,487,825 - 174,549,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,627,363 - 172,688,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,699,240 - 174,760,876 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,978,596 - 182,039,825 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,978,601 - 182,039,332 (+)Ensemblpanpan1.1panPan2
RUFY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,550,554 - 179,610,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,550,554 - 179,610,012 (+)EnsemblGRCh38hg38GRCh38
GRCh375178,977,555 - 179,037,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,910,177 - 178,969,625 (+)NCBINCBI36Build 36hg18NCBI36
Build 345178,910,192 - 178,969,618NCBI
Celera5174,612,171 - 174,665,953 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,702,360 - 173,763,921 (+)NCBIHuRef
CHM1_15178,410,045 - 178,469,474 (+)NCBICHM1_1
T2T-CHM13v2.05180,103,365 - 180,164,461 (+)NCBIT2T-CHM13v2.0
Rufy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,280,113 - 50,322,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,280,113 - 50,321,952 (-)EnsemblGRCm39 Ensembl
GRCm381150,389,286 - 50,431,274 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,389,286 - 50,431,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,202,805 - 50,244,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,232,726 - 50,274,534 (-)NCBIMGSCv36mm8
Celera1154,949,903 - 54,991,689 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.57NCBI
Rufy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,206,801 - 35,251,696 (-)NCBIGRCr8
mRatBN7.21034,705,741 - 34,750,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,705,741 - 34,750,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,378,111 - 39,422,479 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,917,367 - 7,961,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,371,793 - 34,416,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,882,805 - 35,927,268 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,882,805 - 35,927,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,653,747 - 35,698,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,933,369 - 35,977,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,934,430 - 35,979,017 (-)NCBI
Celera1034,055,043 - 34,099,309 (-)NCBICelera
Cytogenetic Map10q22NCBI
Rufy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408947,317 - 982,333 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955408946,842 - 991,717 (-)NCBIChiLan1.0ChiLan1.0
RUFY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,062,623 - 2,127,613 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,052,901 - 2,127,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,185,367 - 2,250,065 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,036,939 - 2,101,959 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,036,949 - 2,101,950 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,008,407 - 2,073,373 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,087,009 - 2,151,921 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,327,760 - 2,392,746 (-)NCBIUU_Cfam_GSD_1.0
Rufy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,938,899 - 119,996,308 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,148,689 - 1,206,064 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,148,676 - 1,206,485 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUFY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,963,989 - 79,021,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,974,361 - 79,021,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,540,978 - 80,588,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RUFY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,260,109 - 81,326,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,269,663 - 81,330,154 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,622,380 - 12,694,016 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rufy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,490,851 - 42,537,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,490,864 - 42,537,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000034874   ⟹   ENSPPAP00000012212
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5181,978,601 - 182,039,332 (+)Ensembl
RefSeq Acc Id: XM_034961170   ⟹   XP_034817061
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24174,487,825 - 174,549,376 (+)NCBI
NHGRI_mPanPan15172,627,364 - 172,688,915 (+)NCBI
Mhudiblu_PPA_v05174,699,240 - 174,760,876 (+)NCBI
RefSeq Acc Id: XM_034961173   ⟹   XP_034817064
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24174,496,907 - 174,549,376 (+)NCBI
NHGRI_mPanPan15172,636,444 - 172,688,915 (+)NCBI
Mhudiblu_PPA_v05174,708,320 - 174,760,876 (+)NCBI
RefSeq Acc Id: XM_063604336   ⟹   XP_063460406
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24174,487,825 - 174,549,376 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034817061 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817064 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012212.1
RefSeq Acc Id: XP_034817061   ⟸   XM_034961170
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A4I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817064   ⟸   XM_034961173
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A4I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000012212   ⟸   ENSPPAT00000034874
RefSeq Acc Id: XP_063460406   ⟸   XM_063604336
- Peptide Label: isoform X1
Protein Domains
FYVE-type   RING-type   RUN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034874.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  1.20.58.900 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro FYVE_RUFY1 UniProtKB/TrEMBL
  RUFY1-3 UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_RUFY1 UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene RUFY1 ENTREZGENE
PANTHER RUN AND FYVE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
PROSITE RUN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
Superfamily-SCOP SSF140741 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A2R9A4I0 ENTREZGENE, UniProtKB/TrEMBL