CYP19A1 (cytochrome P450 family 19 subfamily A member 1) - Rat Genome Database

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Gene: CYP19A1 (cytochrome P450 family 19 subfamily A member 1) Pan paniscus
Analyze
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
RGD ID: 11679189
Description: ENCODES a protein that exhibits aromatase activity (ortholog); oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (ortholog); INVOLVED IN adrenal gland development (ortholog); androgen metabolic process (ortholog); bile acid metabolic process (ortholog); PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Alzheimer's disease (ortholog); amenorrhea (ortholog); FOUND IN axon terminus (ortholog); dendritic spine (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aromatase; LOC100984744
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21640,450,148 - 40,558,353 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11544,628,633 - 44,758,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,152,924 - 30,282,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11548,486,688 - 48,616,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
androgen catabolic process  (IEA)
androgen metabolic process  (ISO)
bile acid metabolic process  (ISO)
biphenyl metabolic process  (ISO)
bone development  (ISO)
C21-steroid hormone metabolic process  (ISO)
calcineurin-mediated signaling  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
estrogen biosynthetic process  (ISO)
female genitalia development  (ISO)
female gonad development  (IEA,ISO)
granulocyte differentiation  (ISO)
hippocampus development  (ISO)
hypothalamus development  (ISO)
luteinization  (ISO)
male gonad development  (ISO)
mammary gland development  (ISO)
melatonin metabolic process  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of macrophage chemotaxis  (ISO)
phthalate metabolic process  (ISO)
positive regulation of estradiol secretion  (IEA)
prostate gland growth  (ISO)
regulation of synapse structure or activity  (ISO)
response to cesium ion  (ISO)
response to estradiol  (IEA,ISO)
response to estrogen  (ISO)
response to herbicide  (ISO)
response to ionizing radiation  (ISO)
response to metal ion  (ISO)
response to organic cyclic compound  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
testosterone biosynthetic process  (ISO)
uterus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP19A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21640,450,148 - 40,558,353 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11544,628,633 - 44,758,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,152,924 - 30,282,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11548,486,688 - 48,616,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensemblpanpan1.1panPan2
CYP19A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,208,057 - 51,338,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,208,057 - 51,338,601 (-)EnsemblGRCh38hg38GRCh38
GRCh371551,500,254 - 51,630,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,288,961 - 49,418,086 (-)NCBINCBI36Build 36hg18NCBI36
Celera1528,393,650 - 28,524,194 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1528,330,314 - 28,460,872 (-)NCBIHuRef
CHM1_11551,618,344 - 51,748,904 (-)NCBICHM1_1
T2T-CHM13v2.01549,015,801 - 49,146,366 (-)NCBIT2T-CHM13v2.0
Cyp19a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,073,221 - 54,175,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,073,221 - 54,175,394 (-)EnsemblGRCm39 Ensembl
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBIMGSCv36mm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
Cyp19a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8863,449,148 - 63,476,534 (-)NCBIGRCr8
mRatBN7.2854,552,978 - 54,580,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,553,165 - 54,580,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,087,103 - 60,114,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,366,113 - 58,393,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,230,358 - 56,257,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
LOC102023780
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,266,233 - 3,313,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,198,622 - 3,313,072 (+)NCBIChiLan1.0ChiLan1.0
CYP19A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,954,020 - 17,056,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,101,433 - 17,133,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBIUU_Cfam_GSD_1.0
LOC101954950
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864095,258,165 - 95,328,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647113,107,603 - 13,136,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647113,107,603 - 13,136,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP19A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,367,667 - 120,695,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,652,172 - 120,695,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21133,903,926 - 133,936,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP19A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,074,260 - 32,164,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,132,425 - 32,164,277 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048109,028,218 - 109,061,355 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101702005
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,053,803 - 9,100,212 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,053,644 - 9,100,212 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035394   ⟹   ENSPPAP00000012728
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035399   ⟹   ENSPPAP00000012733
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1548,491,080 - 48,521,554 (-)Ensembl
RefSeq Acc Id: XM_024925634   ⟹   XP_024781402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21640,450,148 - 40,521,887 (-)NCBI
NHGRI_mPanPan11544,628,633 - 44,702,308 (-)NCBI
Mhudiblu_PPA_v01530,152,924 - 30,222,930 (-)NCBI
PanPan1.11548,488,104 - 48,556,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055098469   ⟹   XP_054954444
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21640,450,148 - 40,558,353 (-)NCBI
NHGRI_mPanPan11544,628,633 - 44,738,633 (-)NCBI
RefSeq Acc Id: XM_055098471   ⟹   XP_054954446
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21640,450,148 - 40,558,123 (-)NCBI
NHGRI_mPanPan11544,628,633 - 44,738,612 (-)NCBI
RefSeq Acc Id: XM_063596643   ⟹   XP_063452713
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21640,450,148 - 40,503,210 (-)NCBI
RefSeq Acc Id: XM_063596644   ⟹   XP_063452714
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21640,450,148 - 40,542,689 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_024781402   ⟸   XM_024925634
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A604 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000012733   ⟸   ENSPPAT00000035399
RefSeq Acc Id: ENSPPAP00000012728   ⟸   ENSPPAT00000035394
RefSeq Acc Id: XP_054954444   ⟸   XM_055098469
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A604 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954446   ⟸   XM_055098471
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063452714   ⟸   XM_063596644
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A604 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063452713   ⟸   XM_063596643
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A604 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029532 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035394.1 UniProtKB/TrEMBL
  ENSPPAT00000035399.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC100984744 ENTREZGENE
PANTHER AROMATASE UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A2R9A604 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A611_PANPA UniProtKB/TrEMBL
VGNC ID VGNC:83034 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP19A1  cytochrome P450 family 19 subfamily A member 1  LOC100984744  aromatase  Symbol and/or name change 5135510 APPROVED