MAPK15 (mitogen-activated protein kinase 15) - Rat Genome Database

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Gene: MAPK15 (mitogen-activated protein kinase 15) Pan paniscus
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Symbol: MAPK15
Name: mitogen-activated protein kinase 15
RGD ID: 11675085
Description: ENCODES a protein that exhibits ATP binding (inferred); chromatin binding (inferred); kinase activity (inferred); INVOLVED IN negative regulation of DNA replication (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH breast cancer (ortholog); Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); FOUND IN axoneme (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,198,908 - 161,205,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,716,178 - 136,722,428 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,468,365 - 140,474,604 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,482,245 - 143,488,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,481,567 - 143,492,859 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
caveolin-mediated endocytosis  (IEA)
cellular response to amino acid starvation  (IEA)
cellular response to stress  (IEA)
DNA damage response  (IEA)
dopamine uptake  (IEA)
endoplasmic reticulum organization  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
MAPK cascade  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of DNA replication  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage proliferation  (IEA)
positive regulation of metaphase/anaphase transition of meiosis I  (IEA)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of spindle assembly  (IEA)
positive regulation of telomere maintenance  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
protein autophosphorylation  (ISO)
protein localization to ciliary transition zone  (IEA)
protein phosphorylation  (ISO)
regulation of autophagy  (IEA)
regulation of cilium assembly  (IEA)
regulation of COPII vesicle coating  (IEA)
regulation of cytoskeleton organization  (IEA)
regulation of early endosome to late endosome transport  (IEA)
regulation of Golgi inheritance  (IEA)
regulation of stress-activated MAPK cascade  (IEA)
response to epidermal growth factor  (IEA)
response to estradiol  (ISO)
stress-activated MAPK cascade  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPK15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,198,908 - 161,205,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,716,178 - 136,722,428 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,468,365 - 140,474,604 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,482,245 - 143,488,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,481,567 - 143,492,859 (+)Ensemblpanpan1.1panPan2
MAPK15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,716,349 - 143,722,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,716,340 - 143,722,458 (+)EnsemblGRCh38hg38GRCh38
GRCh378144,798,519 - 144,804,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,870,495 - 144,876,621 (+)NCBINCBI36Build 36hg18NCBI36
Celera8141,109,455 - 141,115,595 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,051,333 - 140,057,442 (+)NCBIHuRef
CHM1_18144,838,551 - 144,844,676 (+)NCBICHM1_1
T2T-CHM13v2.08144,872,787 - 144,878,895 (+)NCBIT2T-CHM13v2.0
Mapk15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,865,581 - 75,871,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,865,618 - 75,871,003 (+)EnsemblGRCm39 Ensembl
GRCm381575,993,732 - 75,999,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,993,769 - 75,999,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371575,824,199 - 75,829,583 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,821,024 - 75,826,408 (+)NCBIMGSCv36mm8
Celera1577,494,814 - 77,500,199 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.2NCBI
Mapk15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,575,619 - 109,595,339 (+)NCBIGRCr8
GRCr8 Ensembl7109,575,561 - 109,595,346 (+)EnsemblGRCr8 Ensembl
mRatBN7.27107,694,907 - 107,714,640 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,694,964 - 107,714,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,448,581 - 109,453,894 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,672,256 - 111,677,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,618,237 - 111,623,549 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,041,287 - 117,061,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,055,395 - 117,061,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,027,214 - 117,046,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,026,694 - 114,032,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,066,261 - 104,071,573 (+)NCBICelera
RGSC_v3.17114,060,919 - 114,066,236 (+)NCBI
Cytogenetic Map7q34NCBI
Mapk15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,413,822 - 2,419,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,413,393 - 2,420,703 (+)NCBIChiLan1.0ChiLan1.0
MAPK15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,317,061 - 37,322,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,316,424 - 37,322,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,273,594 - 37,279,329 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,789,031 - 37,794,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,789,106 - 37,794,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,463,171 - 37,468,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,580,097 - 37,585,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,061,417 - 38,067,119 (+)NCBIUU_Cfam_GSD_1.0
Mapk15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303994,469 - 1,000,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,420,732 - 8,425,884 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364708,420,850 - 8,425,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4909,268 - 915,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14909,266 - 915,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,932,291 - 137,938,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8137,932,364 - 137,938,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,942,955 - 1,949,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473513,047,125 - 13,056,308 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473513,049,509 - 13,077,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000051115   ⟹   ENSPPAP00000028269
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8143,481,567 - 143,492,859 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000051124   ⟹   ENSPPAP00000028278
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl8143,482,363 - 143,486,652 (+)Ensembl
RefSeq Acc Id: XM_003819448   ⟹   XP_003819496
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v27161,198,911 - 161,205,165 (+)NCBI
NHGRI_mPanPan18136,716,181 - 136,722,426 (+)NCBI
Mhudiblu_PPA_v08140,468,372 - 140,474,604 (+)NCBI
PanPan1.18143,482,245 - 143,488,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055116045   ⟹   XP_054972020
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v27161,198,908 - 161,205,165 (+)NCBI
NHGRI_mPanPan18136,716,178 - 136,722,428 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003819496 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972020 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028269.1
  ENSPPAP00000028278.1
  ENSPPAP00050038721
RefSeq Acc Id: XP_003819496   ⟸   XM_003819448
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BF42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000028269   ⟸   ENSPPAT00000051115
Ensembl Acc Id: ENSPPAP00000028278   ⟸   ENSPPAT00000051124
RefSeq Acc Id: XP_054972020   ⟸   XM_055116045
- Peptide Label: isoform X1
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037186 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050027934 ENTREZGENE
Ensembl Transcript ENSPPAT00000051115.1 UniProtKB/TrEMBL
  ENSPPAT00000051124.1 UniProtKB/TrEMBL
  ENSPPAT00050059473 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report pps:100972270 UniProtKB/TrEMBL
NCBI Gene MAPK15 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BF42 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BG92_PANPA UniProtKB/TrEMBL