F2R (coagulation factor II thrombin receptor) - Rat Genome Database

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Pathways
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Gene: F2R (coagulation factor II thrombin receptor) Pan paniscus
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Symbol: F2R (Ensembl: F2RL1)
Name: coagulation factor II thrombin receptor (Ensembl:F2R like trypsin receptor 1)
RGD ID: 11673386
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); G-protein alpha-subunit binding (inferred); G-protein beta-subunit binding (inferred); INVOLVED IN positive regulation of apoptotic process (ortholog); positive regulation of GTPase activity (ortholog); PARTICIPATES IN protease mediated signaling via protease-activated receptor 1; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Experimental Neoplasms (ortholog); hepatitis (ortholog); FOUND IN caveola (inferred); cell surface (inferred); early endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F2R like trypsin receptor 1; F2RL1; proteinase-activated receptor 1; proteinase-activated receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,567,568 - 38,589,598 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,723,130 - 36,742,780 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,462,521 - 38,478,882 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,008,288 - 39,024,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (IEA)
connective tissue replacement involved in inflammatory response wound healing  (IEA)
dendritic cell homeostasis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
homeostasis of number of cells within a tissue  (IEA)
inflammatory response  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of renin secretion into blood stream  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
platelet activation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood coagulation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of collagen biosynthetic process  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of GTPase activity  (ISO)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of vasoconstriction  (IEA)
regulation of biological quality  (IEA)
regulation of blood coagulation  (IEA)
regulation of interleukin-1 beta production  (IEA)
regulation of synaptic plasticity  (IEA)
response to lipopolysaccharide  (IEA)
response to wounding  (IEA)
thrombin-activated receptor signaling pathway  (IEA)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,567,568 - 38,589,598 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,723,130 - 36,742,780 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,462,521 - 38,478,882 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,008,288 - 39,024,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)Ensemblpanpan1.1panPan2
F2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,011,951 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,798 (+)NCBICHM1_1
T2T-CHM13v2.0577,198,009 - 77,217,657 (+)NCBIT2T-CHM13v2.0
F2rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,648,226 - 95,661,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,648,240 - 95,661,735 (-)EnsemblGRCm39 Ensembl
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBIMGSCv36mm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
F2rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,507,003 - 28,519,954 (-)NCBIGRCr8
mRatBN7.2226,772,274 - 26,785,226 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,810,431 - 33,823,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,910,649 - 31,923,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,726,513 - 26,739,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
F2rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,050,901 - 24,054,039 (-)NCBIChiLan1.0ChiLan1.0
F2RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBIUU_Cfam_GSD_1.0
F2rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,705,232 - 190,716,606 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549141,512 - 153,602 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549142,281 - 153,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,732,189 - 85,750,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,732,082 - 85,747,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,813 - 87,364,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2RL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,095,446 - 71,109,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2rl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,326,605 - 1,337,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003808379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000026221   ⟹   ENSPPAP00000005881
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000046368   ⟹   ENSPPAP00000023543
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000046371   ⟹   ENSPPAP00000023546
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl539,128,896 - 39,129,359 (-)Ensembl
RefSeq Acc Id: XM_003808379   ⟹   XP_003808427
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2438,567,568 - 38,589,598 (-)NCBI
NHGRI_mPanPan1536,723,130 - 36,742,780 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003808427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000023543
  ENSPPAP00000023543.1
  ENSPPAP00000023546.1
Ensembl Acc Id: ENSPPAP00000005881   ⟸   ENSPPAT00000026221
Ensembl Acc Id: ENSPPAP00000023543   ⟸   ENSPPAT00000046368
Ensembl Acc Id: ENSPPAP00000023546   ⟸   ENSPPAT00000046371
RefSeq Acc Id: XP_003808427   ⟸   XM_003808379
- UniProtKB: A0A2R9B5R1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000023823 Ensembl, ENTREZGENE
  ENSPPAG00000034950 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000046368.1 UniProtKB/TrEMBL
  ENSPPAT00000046371.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/TrEMBL
  Thrmbn_rcpt UniProtKB/TrEMBL
KEGG Report pps:100985711 UniProtKB/TrEMBL
NCBI Gene F2RL1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 1 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/TrEMBL
  THROMBINR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R9B1X8_PANPA UniProtKB/TrEMBL
  A0A2R9B5R1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 F2R  coagulation factor II thrombin receptor  F2RL1  F2R like trypsin receptor 1  Symbol and/or name change 5135510 APPROVED
2023-04-20 F2RL1  F2R like trypsin receptor 1  F2R  coagulation factor II thrombin receptor  Data merged from RGD:11676079 737654 PROVISIONAL